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9-Aminoacridine peptide derivatives as versatile reporter systems for use in fluorescence lifetime assays.

Maltman, Beatrice A; Dunsmore, Colin J; Couturier, Sarah C M; Tirnaveanu, Adina E; Delbederi, Zoica; McMordie, R Austin S; Naredo, Gregorio; Ramage, Robert; Cotton, Graham.

Chem Commun (Camb) ; 46(37): 6929-31, 2010 Oct 07.

Article in English | MEDLINE | ID: mdl-20733984

ABSTRACT

A novel long lifetime fluorescence reporter based on 9-aminoacridine was designed, the lifetime of which can be modulated in a defined manner when in proximity to a tryptophan residue enabling fluorescence lifetime based biochemical assays to be configured.

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Aminacrine/chemistry , Biological Assay/methods , Fluorescence , Peptides/chemistry , Molecular Structure , Peptides/chemical synthesis

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