ABSTRACT
Comparison of 1085 patients having coronary bypass surgery without cardioplegia from Jan. 1970 to Aug. 8, 1977 with 1060 patients operated upon with cardioplegia from Aug. 9, 1977 to Dec. 31, 1980 suggests that improved myocardial protection afforded by cardioplegia combined with profound topical hypothermia has its principal impact in those patients requiring urgent or emergency operations by reducing the probability of intraoperative left ventricular failure after coronary bypass. The need for postoperative balloon pumping and the risk of intraoperative death were significantly lower in patients operated upon with hypothermia + cardioplegia myocardial protection. In patients who survived 30 days after operation there was no significant improvement in long-term survival, incidence of myocardial infarction, or recurrence of angina pectoris in the cardioplegia group despite a greater average number of grafts per patient and a smaller number of ungrafted but obstructed coronary arteries.
Subject(s)
Coronary Artery Bypass , Coronary Disease/surgery , Heart Arrest, Induced , Adult , Aged , Angioplasty, Balloon , Cardiac Catheterization , Coronary Disease/diagnostic imaging , Coronary Disease/physiopathology , Female , Hemodynamics , Humans , Hypothermia, Induced , Male , Middle Aged , RadiographySubject(s)
Antihypertensive Agents/therapeutic use , Guanidines/therapeutic use , Hypertension/physiopathology , Phenylacetates/therapeutic use , Adult , Blood Pressure/drug effects , Coronary Disease/diagnosis , Follow-Up Studies , Guanfacine , Humans , Hypertension/drug therapy , Male , Middle AgedSubject(s)
Coronary Disease/prevention & control , Primary Prevention , Adult , Coronary Disease/epidemiology , Czechoslovakia , Humans , Industry , Male , Middle AgedSubject(s)
Phlebitis/epidemiology , Varicose Veins/epidemiology , Adult , Czechoslovakia , Female , Humans , Male , Middle Aged , Syndrome , Varicose Ulcer/epidemiologyABSTRACT
Following on the epidemiological study of cardiovascular diseases carried out in the rural population of Northern Bohemia in 1970 a long-term ischaemic heart disease prevention programme was launched in a group of 2582 men aged between 30-59 years, worked of two automobile plants in the district of Mladá Boleslav. Under der programme "Protected Your Heart", sponsored by the Automobile Works National Enterprise (AZNP), workers were urged to adjust their food intake in keeping with the principles of rational nutrition, to stop smoking and to take regular after-work cross-country 4 km/1 hr walks. No such programme was carried out at the automobile plant LIAZ serving as control.
Subject(s)
Coronary Disease/prevention & control , Occupational Health Services , Adult , Coronary Disease/epidemiology , Czechoslovakia , Humans , Male , Middle AgedSubject(s)
Myocardial Infarction/epidemiology , Adult , Aged , Czechoslovakia , Female , Humans , Male , Middle AgedSubject(s)
Coronary Disease/epidemiology , Industry , Adult , Automobiles , Coronary Disease/diagnosis , Czechoslovakia , Humans , Male , Middle Aged , RiskSubject(s)
Coronary Disease/prevention & control , Adult , Coronary Disease/diagnosis , Coronary Disease/epidemiology , Czechoslovakia , Humans , Male , Middle Aged , RiskSubject(s)
Coronary Disease/diagnosis , Adult , Coronary Disease/epidemiology , Coronary Disease/prevention & control , Humans , Male , Middle Aged , Prognosis , RiskSubject(s)
Coronary Disease/diagnosis , Exercise Test , Adult , Electrocardiography , Humans , Male , Middle Aged , RiskSubject(s)
Blood Pressure , Physical Exertion , Renin/blood , Adult , Humans , Hypertension/etiology , Male , Middle AgedSubject(s)
Blood Pressure , Physical Exertion , Renin/blood , Adult , Age Factors , Humans , Male , Middle AgedSubject(s)
Coronary Disease/prevention & control , Adult , Automobiles , Czechoslovakia , Diet , Humans , Industry , Male , Middle Aged , Occupations , Physical Fitness , Smoking PreventionABSTRACT
A longitudinal epidemiological study of ischaemic heart disease (IHD) in men aged 40-59 years showed that the five-year incidence of the manifest form was 7.8% in agricultural workers and 9.7% in industrial employees. The corresponding incidence of the latent form was 9.0% and 12.2%, respectively. The differences in the incidence of both forms between the population samples studied was at the border of statistical significance. The importance of risk factors was evaluated on the basis of the score represented by the difference between the respective five-year incidence of IHD in subjects with and without the risk factors concerned. The highest relative scores were found with systolic and diastolic hypertension, positive family history and obesity. For prognostic purposes, the total relative risk, represented by the sum of the scores of the risk factors proved to be useful. Autopsies confirmed that a total relative risk exceeding 40% was a sensitive indicator of morphological substrate of coronary heart disease.
