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1.
RSC Adv ; 11(62): 39428-39437, 2021 Dec 06.
Article in English | MEDLINE | ID: mdl-35492493

ABSTRACT

The directions of the transformation of benzene induced by low-voltage discharges at various energies of pulsed discharges were revealed. This paper shows the dependencies of the morphology and other characteristics of nanostructures obtained in the induced transformation of benzene on the energy of pulsed discharges. Nanostructures with different morphologies are formed when the energy of the low-voltage discharges changes during the induced transformation of benzene in the liquid phase. Two types of carbon nanostructures were formed in the induced destruction of benzene with a 90 µF capacitor. The first type of structure includes graphite fibers, two- and three-layer graphene sheets, as well as two- and three-layer hollow spheres and microstructures in the form of CNHs. The microstructures of the second type were onion-like spheroids. An increase in the capacitance up to 20 090 µF led to the formation of two types of nanostructures: onion-like spheroids and carbon fibers. A further increase in the capacitance to 40 090 µF caused the formation of onion-like spheroids.

2.
J Cereb Blood Flow Metab ; 37(1): 252-262, 2017 01.
Article in English | MEDLINE | ID: mdl-26721391

ABSTRACT

Presently, visual and quantitative approaches for image-supported diagnosis of dementing disorders rely on regional intensity rather than on connectivity measurements. Here, we test metabolic connectivity for differentiation between Alzheimer's disease and frontotemporal lobar degeneration. Positron emission tomography with 18F-fluorodeoxyglucose was conducted in 47 patients with mild Alzheimer's disease, 52 patients with mild frontotemporal lobar degeneration, and 45 healthy elderly subjects. Sparse inverse covariance estimation and selection were used to identify patterns of metabolic, inter-subject covariance on the basis of 60 regional values. Relative to healthy subjects, significantly more pathological within-lobe connections were found in the parietal lobe of patients with Alzheimer's disease, and in the frontal and temporal lobes of subjects with frontotemporal lobar degeneration. Relative to the frontotemporal lobar degeneration group, more pathological connections between the parietal and temporal lobe were found in the Alzheimer's disease group. The obtained connectivity patterns differentiated between two patients groups with an overall accuracy of 83%. Linear discriminant analysis and univariate methods provided an accuracy of 74% and 69%, respectively. There are characteristic patterns of abnormal metabolic connectivity in mild Alzheimer's disease and frontotemporal lobar degeneration. Such patterns can be utilized for single-subject analyses and might be more accurate in the differential diagnosis of dementing disorders than traditional intensity-based analyses.


Subject(s)
Alzheimer Disease/diagnosis , Dementia/diagnosis , Frontotemporal Lobar Degeneration/diagnosis , Metabolic Networks and Pathways , Aged , Alzheimer Disease/diagnostic imaging , Alzheimer Disease/metabolism , Brain Mapping/methods , Case-Control Studies , Dementia/diagnostic imaging , Dementia/metabolism , Diagnosis, Differential , Female , Fluorodeoxyglucose F18 , Frontotemporal Lobar Degeneration/diagnostic imaging , Frontotemporal Lobar Degeneration/metabolism , Humans , Male , Parietal Lobe/metabolism , Positron-Emission Tomography , Temporal Lobe/metabolism
3.
J Cereb Blood Flow Metab ; 35(7): 1122-6, 2015 Jul.
Article in English | MEDLINE | ID: mdl-25785830

ABSTRACT

Positron emission tomography (PET) data are commonly analyzed in terms of regional intensity, while covariant information is not taken into account. Here, we searched for network correlates of healthy cognitive function in resting state PET data. PET with [(18)F]-fluorodeoxyglucose and a test of verbal working memory (WM) were administered to 35 young healthy adults. Metabolic connectivity was modeled at a group level using sparse inverse covariance estimation. Among 13 WM-relevant Brodmann areas (BAs), 6 appeared to be robustly connected. Connectivity within this network was significantly stronger in subjects with above-median WM performance. In respect to regional intensity, i.e., metabolism, no difference between groups was found. The results encourage examination of covariant patterns in FDG-PET data from non-neurodegenerative populations.


Subject(s)
Brain/anatomy & histology , Brain/metabolism , Memory, Short-Term , Nerve Net/anatomy & histology , Nerve Net/metabolism , Adult , Female , Fluorodeoxyglucose F18/analysis , Humans , Male , Models, Anatomic , Positron-Emission Tomography/methods , Young Adult
4.
Nucl Med Biol ; 41 Suppl: e7-15, 2014 May.
Article in English | MEDLINE | ID: mdl-24434013

ABSTRACT

INTRODUCTION: The field of nuclear medicine is reliant on radionuclides for medical imaging procedures and radioimmunotherapy (RIT). The recent shut-downs of key radionuclide producers have highlighted the fragility of the current radionuclide supply network, however. To ensure that nuclear medicine can continue to grow, adding new diagnostic and therapy options to healthcare, novel and reliable production methods are required. Siemens are developing a low-energy, high-current - up to 10 MeV and 1 mA respectively - accelerator. The capability of this low-cost, compact system for radionuclide production, for use in nuclear medicine procedures, has been considered. METHODOLOGY: The production of three medically important radionuclides - (89)Zr, (64)Cu, and (103)Pd - has been considered, via the (89)Y(p,n), (64)Ni(p,n) and (103)Rh(p,n) reactions, respectively. Theoretical cross-sections were generated using TALYS and compared to experimental data available from EXFOR. Stopping power values generated by SRIM have been used, with the TALYS-generated excitation functions, to calculate potential yields and isotopic purity in different irradiation regimes. RESULTS: The TALYS excitation functions were found to have a good agreement with the experimental data available from the EXFOR database. It was found that both (89)Zr and (64)Cu could be produced with high isotopic purity (over 99%), with activity yields suitable for medical diagnostics and therapy, at a proton energy of 10MeV. At 10MeV, the irradiation of (103)Rh produced appreciable quantities of (102)Pd, reducing the isotopic purity. A reduction in beam energy to 9.5MeV increased the radioisotopic purity to 99% with only a small reduction in activity yield. CONCLUSION: This work demonstrates that the low-energy, compact accelerator system under development by Siemens would be capable of providing sufficient quantities of (89)Zr, (64)Cu, and (103)Pd for use in medical diagnostics and therapy. It is suggested that the system could be used to produce many other isotopes currently useful to nuclear medicine.


Subject(s)
Nuclear Medicine , Particle Accelerators , Radiochemistry/instrumentation , Radioisotopes/chemistry
5.
Nature ; 456(7222): 620-3, 2008 Dec 04.
Article in English | MEDLINE | ID: mdl-19052623

ABSTRACT

When seen in ultraviolet light, Venus has contrast features that arise from the non-uniform distribution of unknown absorbers within the sulphuric acid clouds and seem to trace dynamical activity in the middle atmosphere. It has long been unclear whether the global pattern arises from differences in cloud top altitude (which was earlier estimated to be 66-72 km), compositional variations or temperature contrasts. Here we report multi-wavelength imaging that reveals that the dark low latitudes are dominated by convective mixing which brings the ultraviolet absorbers up from depth. The bright and uniform mid-latitude clouds reside in the 'cold collar', an annulus of cold air characterized by approximately 30 K lower temperatures with a positive lapse rate, which suppresses vertical mixing and cuts off the supply of ultraviolet absorbers from below. In low and middle latitudes, the visible cloud top is located at a remarkably constant altitude of 72 +/- 1 km in both the ultraviolet dark and bright regions, indicating that the brightness variations result from compositional differences caused by the colder environment rather than by elevation changes. The cloud top descends to approximately 64 km in the eye of the hemispheric vortex, which appears as a depression in the upper cloud deck. The ultraviolet dark circular streaks enclose the vortex eye and are dynamically connected to it.

6.
Nature ; 450(7170): 629-32, 2007 Nov 29.
Article in English | MEDLINE | ID: mdl-18046393

ABSTRACT

Venus is Earth's near twin in mass and radius, and our nearest planetary neighbour, yet conditions there are very different in many respects. Its atmosphere, mostly composed of carbon dioxide, has a surface temperature and pressure far higher than those of Earth. Only traces of water are found, although it is likely that there was much more present in the past, possibly forming Earth-like oceans. Here we discuss how the first year of observations by Venus Express brings into focus the evolutionary paths by which the climates of two similar planets diverged from common beginnings to such extremes. These include a CO2-driven greenhouse effect, erosion of the atmosphere by solar particles and radiation, surface-atmosphere interactions, and atmospheric circulation regimes defined by differing planetary rotation rates.

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