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Vopr Virusol ; 28(5): 607-11, 1983.
Article in Russian | MEDLINE | ID: mdl-6659476

ABSTRACT

Four cell lines derived from tumors induced by adenovirus SA7, its DNA (intact and fragmented with restrictase Sal-1), as well as isolated C-Sal-1 fragment (19.5% of genome) containing oncogene were studied. All the cell lines had the phenotypic markers of tumor cells, similar tumorigenicity, and produced T- and S-antigens. The line derived from the tumor induced by intact DNA contained the smallest adenovirus SA7 genome region (12%) which suggests that the information required for the synthesis of T and S antigens of adenovirus SA7 lies within the limits of this genome region.


Subject(s)
Adenoviridae/pathogenicity , Adenoviruses, Simian/pathogenicity , DNA, Viral/pharmacology , Neoplasms, Experimental/etiology , Adenoviruses, Simian/genetics , Adenoviruses, Simian/immunology , Animals , Animals, Newborn , Antigens, Viral, Tumor/analysis , Cell Line , Cell Transformation, Neoplastic/ultrastructure , Chlorocebus aethiops , Cricetinae , DNA, Viral/genetics , Gene Expression Regulation , Genes, Viral , Mesocricetus , Neoplasms, Experimental/genetics , Neoplasms, Experimental/immunology , Oncogenes , Virus Cultivation
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