Cross-Sectional Associations of Sedentary Behavior and Sitting with Serum Lipid Biomarkers in Midlife.

INTRODUCTION: Physical inactivity, excessive total time spent in sedentary behavior (SB) and prolonged sedentary bouts have been proposed to be risk factors for chronic disease morbidity and mortality worldwide. However, which patterns and postures of SB have the most negative impacts on health outcomes is still unclear. This population-based study aimed to investigate the independent associations of the patterns of accelerometer-based overall SB and sitting with serum lipid biomarkers at different moderate- to vigorous-intensity physical activity (MVPA) levels. METHODS: Physical activity and SB were measured in a birth cohort sample ( N = 3272) at 46 yr using a triaxial hip-worn accelerometer in free-living conditions for 14 d. Raw acceleration data were classified into SB and PA using a machine learning-based model, and the bouts of overall SB and sitting were identified from the classified data. The participants also answered health-related questionnaires and participated in clinical examinations. Associations of overall SB (lying and sitting) and sitting patterns with serum lipid biomarkers were investigated using linear regression. RESULTS: The overall SB patterns were more consistently associated with serum lipid biomarkers than the sitting patterns after adjustments. Among the participants with the least and the most MVPA, high total time spent in SB and SB bouts of 15-29.99 and ≥30 min were associated with impaired lipid metabolism. Among those with moderate amount of MVPA, higher time spent in SB and SB bouts of 15-29.99 min was unfavorably associated with serum lipid biomarkers. CONCLUSIONS: The associations between SB patterns and serum lipid biomarkers were dependent on MVPA level, which should be considered when planning evidence-based interventions to decrease SB in midlife.

Machine-learning models for activity class prediction: A comparative study of feature selection and classification algorithms.

PURPOSE: Machine-learning (ML) approaches have been repeatedly coupled with raw accelerometry to classify physical activity classes, but the features required to optimize their predictive performance are still unknown. Our aim was to identify appropriate combination of feature subsets and prediction algorithms for activity class prediction from hip-based raw acceleration data. METHODS: The hip-based raw acceleration data collected from 27 participants was split into training (70 %) and validation (30 %) subsets. A total of 206 time- (TD) and frequencydomain (FD) features were extracted from 6-second non-overlapping windows of the signal. Feature selection was done using seven filter-based, two wrapper-based, and one embedded algorithm, and classification was performed with artificial neural network (ANN), support vector machine (SVM), and random forest (RF). For every combination between the feature selection method and the classifiers, the most appropriate feature subsets were found and used for model training within the training set. These models were then validated with the left-out validation set. RESULTS: The appropriate number of features for the ANN, SVM, and RF ranged from 20 to 45. Overall, the accuracy of all the three classifiers was higher when trained with feature subsets generated using filter-based methods compared with when they were trained with wrapper-based methods (range: 78.1 %-88 % vs. 66 %-83.5 %). TD features that reflect how signals vary around the mean, how they differ with one another, and how much and how often they change were more frequently selected via the feature selection methods. CONCLUSIONS: A subset of TD features from raw accelerometry could be sufficient for ML-based activity classification if properly selected from different axes.

Evaluating and Enhancing the Generalization Performance of Machine Learning Models for Physical Activity Intensity Prediction From Raw Acceleration Data.

PURPOSE: To evaluate and enhance the generalization performance of machine learning physical activity intensity prediction models developed with raw acceleration data on populations monitored by different activity monitors. METHOD: Five datasets from four studies, each containing only hip- or wrist-based raw acceleration data (two hip- and three wrist-based) were extracted. The five datasets were then used to develop and validate artificial neural networks (ANN) in three setups to classify activity intensity categories (sedentary behavior, light, and moderate-to-vigorous). To examine generalizability, the ANN models were developed using within dataset (leave-one-subject-out) cross validation, and then cross tested to other datasets with different accelerometers. To enhance the models' generalizability, a combination of four of the five datasets was used for training and the fifth dataset for validation. Finally, all the five datasets were merged to develop a single model that is generalizable across the datasets (50% of the subjects from each dataset for training, the remaining for validation). RESULTS: The datasets showed high performance in within dataset cross validation (accuracy 71.9-95.4%, Kappa K = 0.63-0.94). The performance of the within dataset validated models decreased when applied to datasets with different accelerometers (41.2-59.9%, K = 0.21-0.48). The trained models on merged datasets consisting hip and wrist data predicted the left-out dataset with acceptable performance (65.9-83.7%, K = 0.61-0.79). The model trained with all five datasets performed with acceptable performance across the datasets (80.4-90.7%, K = 0.68-0.89). CONCLUSIONS: Integrating heterogeneous datasets in training sets seems a viable approach for enhancing the generalization performance of the models. Instead, within dataset validation is not sufficient to understand the models' performance on other populations with different accelerometers.