ABSTRACT
Immunotropic properties of the interferon-inducing molecular complex (MC) yeast RNA--tilorone hydrochloride have been under study. MC was experimentally studied in vivo to establish its influence on the amount of antibody-forming cells and the level of antibody formation. The influence of MC on the oxygen-generating activity of spleen macrophages was established in the HCT test. MC in a dose of 1.25 mg/kg was shown to considerably activate immunocompetent cells, thus producing pronounced influence on humoral immunity. In addition, the study showed the dose dependence of the influence of MC on individual elements of the immune system as well as differences in the dynamics of immunomodulation caused by the use of high and low doses of MC. The data thus obtained made it possible to regard MC as a promising immunomodulator.
Subject(s)
Anti-Inflammatory Agents/immunology , Hypersensitivity, Delayed/immunology , RNA, Fungal/immunology , Tilorone/immunology , Animals , Anti-Inflammatory Agents/administration & dosage , Anti-Inflammatory Agents/isolation & purification , Antibody-Producing Cells/cytology , Cell Count , Dose-Response Relationship, Immunologic , Down-Regulation , Drug Combinations , Injections, Intraperitoneal , Macrophages/immunology , Macrophages/metabolism , Mice , Mice, Inbred BALB C , Oxygen/metabolism , Phagocytosis/immunology , RNA, Fungal/administration & dosage , RNA, Fungal/isolation & purification , Spleen/immunology , Spleen/metabolism , Tilorone/administration & dosage , Tilorone/isolation & purification , Time Factors , Up-RegulationABSTRACT
In the review of literature and author's own data the participation of pars compacta and pars reticulata of the substantia nigra in mechanisms of epileptic syndrome development and cessation of epileptic activity was shown. The results are given which testified for dependence of substantia nigra-derived effects upon form and intensity of epileptic activity as well as upon neuromediator and peptidergic systems of the brain involvement. The conclusion was made concerning the significance of substantia nigra as a part of antiepileptic system of the brain in the processes of restriction and suppression of epileptiform manifestations.
Subject(s)
Epilepsy/physiopathology , Substantia Nigra/physiopathology , Amino Acids/therapeutic use , Animals , Anticonvulsants/therapeutic use , Epilepsy/drug therapy , Epilepsy/etiology , Receptors, Dopamine/drug effects , Receptors, Dopamine/physiology , Receptors, GABA/drug effects , Receptors, GABA/physiology , Substantia Nigra/drug effectsABSTRACT
Intraventricular injection of cerebrospinal fluid obtained from cats with electroshock seizures resulted in suppression of generalized picrotoxin-induced seizures in rats. Antiepileptic action of cerebrospinal fluid was abolished by partial bilateral midbrain destruction that included the region of colliculi superii. Electrical stimulation of cerebellum in cats with such destructions caused the appearance of a pronase-sensitive antiepileptic substances in cerebrospinal fluid.
