[Assessement of combined impact of hazards on petrochemical and chemical workers' health].

We have conducted a study on working conditions and health status of petrochemical workers. The main hazardous factor of work environment and manufacture process has been found to be work environment air pollution caused by Class 2-3 hazards. Depending on the composition of the current complex of hazards, the manufacture workers comprise three groups determined by the impact of aromatic hydrocarbons, olefin oxides and their combinations. It has been shown that the combined impact of aromatic hydrocarbons and olefin oxides combination may produce a more pronounced hazardous impact on workers' health compared with the impact of aromatic hydrocarbons or olefin oxides taken separately. This may be due to the summing up of biological effects.

[Based on variable toxicologic parameters, evaluation of potential risk from harmful effects under influence of chemical factors].

Using database on toxicologic parameters for industrial chemicals, the authors studied possibility of unfavorable effects in workers exposed to excessive MAC in the air or workplace. Suggestions include modifications for borderlines of hazardous work conditions subclasses according to MAC excess for general toxic chemicals of 1-4 jeopardy classes.

[Disorders of antioxidant defence and their correction in experimental di-isopropyl-phenyl-isocyanate intoxication]. / Narushenie protsessov antioksidantnoi zashchity i ikh korrektsiia v éksperimente pri intoksikatsii 2,6-diizopropilfenilizotsianatom.

Using preventively natural and artificial antioxidants in experiments on white rats enabled to assess role of lipids peroxidation in mechanisms of acute inhalation toxicity caused by 2,6-diisopropylphenylisocyanate. Correlation and regression analysis revealed differences in mechanisms underlying antioxidants effects.

[The toxicological, hygienic and clinical aspects of the action of low levels of organic solvents]. / Toksikologicheskie, gigienicheskie i klinicheskie aspekty deistviia nizkikh urovnei organicheskikh rastvoritelei.

The article presents experimental data showing that Average Shift Concentration (ASC) and Maximal Single Concentration (MSC) for some solvents (tetrachloromethane, tetrachloroethane, dimethylformamide, benzene) are expedient to be justified. Clinical and hygienic materials proved significant health parameters (nervous system, peripheral blood) and urine levels of main metabolites to depend on chlorbenzene and toluene concentrations influencing the workers. Having analyzed the results, the authors recommended following hygienic norms in the air of workplace: for chlorbenzene ASC--50 mg/cu m, MSC--100 mg/cu m; biologic MAC for urine 4-chlorcatechol--0.05 g/l; for toluene ASC--50 mg/cu m, MSC--150 mg/cu m; biologic MAC for urine hippuric acid--1.5 g/l. The article shows some features of ASC and MSC practical application.