ABSTRACT
AIM: To evaluate a hypotensive effect and metabolic neutrality and safety of ACE inhibitor moexipril in postmenopausal women with arterial hypertension (AH), influence on quality of life. MATERIAL AND METHODS: Thirty two hypertensive postmenopausal women (age 63.1 +/- 0.8 years) received moexipril for 4 months. The history of AH was 10.4 +/- 2.3 years, on the average. After a free of drugs week moexipril was given in a dose 7.5 mg/day with titration to 15 mg in 2 weeks and addition (if the target pressure was not achieved) of hydrochlorothiaside in a dose 12.5 mg. The examination included 24-h monitoring of blood pressure, estimation of microalbuminuria (MAU), endothelial function and blood biochemistry. Initially and after 4 weeks of the treatment quality of life was assessed (scales SF-36 and EuroQol). RESULTS: The initial level of office BP was 164.33/94.50 mm Hg, in 3 months a target level was achieved (136/84 mm Hg). It persisted for the next month. Moexipril corrected endothelial function and vascular elasticity in all the patients. MAU fell from 28.28 to 8.10 mg/l. Quality of life improved. Lipid and carbohydrate changes were not registered. CONCLUSION: Moexipril has a hypotensive and nephroprotective effects, improves endothelial function and quality of life in hypertensive postmenopausal women.
Subject(s)
Angiotensin-Converting Enzyme Inhibitors/therapeutic use , Hypertension/drug therapy , Postmenopause , Quality of Life , Tetrahydroisoquinolines/therapeutic use , Female , Follow-Up Studies , Humans , Middle Aged , Time Factors , Treatment OutcomeABSTRACT
Verapamil produced dose-dependent inhibition of ADP- and TAF-induced increase in thrombocyte calcium concentration in hypertensive patients. Sensitivity to verapamil tested by EC50-half-maximal inhibition of responses to hormones can be weakened in vitro by adrenalin and strengthened by papaverin. Thrombocytes of hypertensive patients were individually sensitive to combination of papaverin and verapamil. The cellular sensitivity to verapamil disappeared when clonidine was substituted for verapamil and was restored when papaverin was added to verapamil.
Subject(s)
Blood Platelets/drug effects , Calcium/blood , Hypertension/drug therapy , Verapamil/therapeutic use , Adult , Aged , Blood Platelets/metabolism , Drug Interactions , Epinephrine/pharmacology , Humans , Hypertension/blood , In Vitro Techniques , Male , Middle Aged , Papaverine/pharmacology , Verapamil/pharmacologyABSTRACT
Competitive binding was used to determine the number of binding sites to glucocorticoid hormones in peripheral blood leukocytes of normal subjects, patients with unstable angina pectoris and patients with myocardial infarction. A sharp (2-3-fold) increase in the number of binding sites was observed in patients with myocardial infarction during the first 24 hours after the onset of the disease.
