[Evaluation of the effectiveness of ultratonotherapy in patients with microbial eczema]. / Otsenka effektivnosti primeneniya ul'tratonoterapii u bol'nykh mikrobnoi ekzemoi.

Microbial eczema is a chronic dermatosis with a complex pathogenesis. The result of exposure to various endo- and exogenous trigger factors is the formation of skin dysbiosis in lesions with a predominance of opportunistic and pathogenic flora and, as a result, the development of sensitization. As the main therapy for dysbiotic disorders, it is customary to use antibacterial drugs. However, often the use of systemic antibacterial drugs is not justified and leads to an aggravation of the problem of antibiotic resistance. PURPOSE OF THE STUDY: To evaluate the effectiveness of the use of alternating current on the skin microbiome in the complex therapy of patients with microbial eczema. MATERIAL AND METHODS: 2 groups of 30 patients with chronic moderate course of microbial eczema in the acute stage were examined. In the comparison group, therapy was carried out in accordance with the Federal Clinical Guidelines (antihistamines, detoxification, systemic antibacterial drugs, external combined agents, including a corticosteroid and an antibiotic). Patients of the main group received similar therapy without systemic antibiotics. In addition, to influence the pathogenic microflora of the skin in the lesion in the main group, procedures with supratonal alternating current of low strength were also used. The control group consisted of 30 healthy volunteers. The results were evaluated according to the clinical picture, laboratory parameters of bacteriological examination. RESULTS: During therapy, in patients of the main group and in the comparison group, a positive dynamics of the skin pathological process was noted, and a decrease in microbial colonization of the skin in the lesions of microbial eczema was observed by 4 and 3 times, respectively (p<0.05). CONCLUSION: The proposed method of treatment is not inferior in terms of the effectiveness of traditional therapy, allows to achieve positive clinical dynamics in similar terms, as well as to avoid the widespread use of systemic antibacterial drugs in cases of moderate dermatosis.

[Mechanisms of action and clinical effectiveness of ultratonotherapy in the complex treatment of foot onychomycosis]. / Mekhanizmy deistviya i klinicheskaya effektivnost' ul'tratonoterapii v kompleksnom lechenii onikhomikozov stop.

INTRUDUCTION: A long course of onychomycosis, severe hyperkeratosis, slow growth of the nails of the feet, somatic burden, as well as an increase in the resistance of pathogens often lead to a decrease in the effectiveness of traditional antimycotics, dictating the need to create new methods of therapy. A promising direction of treatment is the use of alternating current of supratonal frequency of high voltage and low power - ultratonotherapy (UT) in combination with antifungal drugs. The article presents data on the mechanisms of action and clinical effectiveness of this method in the complex treatment of foot onychomycosis. AIM OF STUDY: To study the mechanisms of action and evaluate the clinical effectiveness of UT in the complex treatment of foot onychomycosis. MATERIAL AND METHODS: The antifungal effect of UT was studied in the colonies of Trichophyton rubrum and Candida albicans. The distribution of ozone released during the procedure on the affected nail plate was evaluated in vitro using a qualitative chemical reaction and photodermatoscopy. The state of tissue blood flow in the periungual tissues under the influence of UT was studied in vivo by means of ultrasound dopplerographic scanning (USDGS). The clinical effectiveness of the method was evaluated according to the results of complex treatment of patients with foot onychomycosis in comparison with traditional methods of therapy. RESULTS: UT has both fungicidal and fungistatic effects. With a qualitative reaction to ozone, coloring of the surface and small structures of the nail plate was noted. According to the USDGS, after the use of UT, a significant increase in blood supply to the periungual tissues was recorded. The combined use of alternating current of a high voltage ultrasonic frequency with antifungal drugs in patients with foot onychomycosis contributes to the rapid growth of the nail and shorten the duration of mycological cure. CONCLUSION: UT has an antifungal effect and improves microcirculation in the area of the nail bed. In the complex treatment of patients with foot onychomycosis, the method accelerates clinical and mycological cure, stimulates nail growth, which reduces the rate of systemic and local antifungal therapy.

[Features of dermatological pathology on the background of HIV-infection].

Over the past decade, there has been an increasing number of patients infected with HIV. The disease gradually leads to a pronounced immunodeficiency and death. In the vast majority of patients, polymorbidity phenomena are noted, which leads to the need for a differentiated interdisciplinary approach to their management. The knowledge of dermatologists of other dermatological aspects of HIV-infection by dermatologists and doctors will allow timely early detection of HIV-infected patients and avoid diagnostic errors. A clinical follow - up was carried out which showed issues of diagnostics while examining patients with HIV infection in outpatient practice.

Relapsing polychondritis in medical practice of dermatovenerologist.

Recurrentpolyhedritis is a rare rheumatic disorder with a wave-like course, presumably ofautoimmune nature,characterizedbya widespread inflammatorylesion of the cartilaginous structures and other connective tissue of the ears, joints, nose, larynx, trachea, eyes, valvular heart, kidneys and blood vessels.The description of the own observation of recurrent polychondritis.