ABSTRACT
A 67-year-old woman with no specific medical history showed a hard mass on her great toe for several years. The lesion was elastic, round, and had good mobility. An X-ray showed the lesion to be a calcified "chicken wire" lesion; CT and MRI findings indicated it as a benign subcutaneous calcified tumor. Therefore, a resection biopsy was performed. The mass was a 20 x 20 mm calcified tumor diagnosed as tumoral calcinosis. Pathological findings showed that the calcified lesion lay in fibrous connective tissue and characteristic cells were seen around the calcification site. In this case, the lesion was mature and surgical resection was successful. The patient showed no symptoms or recurrence 3 years after the surgery.
Subject(s)
Bone Diseases, Metabolic , Calcinosis , Toes , Aged , Bone Diseases, Metabolic/diagnostic imaging , Bone Diseases, Metabolic/pathology , Bone Diseases, Metabolic/surgery , Calcinosis/diagnostic imaging , Calcinosis/pathology , Calcinosis/surgery , Female , Humans , Radiography , Toes/diagnostic imaging , Toes/surgeryABSTRACT
We designed this study to investigate transplantation of autogenous chondrocytes cultured in atelocollagen gel to treat the injured growth plate. An experimental model of growth arrest was made by resecting the medial two thirds of the left proximal tibial physis in 8-10-week-old Japanese white rabbits. Autogenous chondrocytes, which had been harvested from cartilage of the knee joints, embedded in atelocollagen gel, and cultured for a week, were transplanted into the defect in the growth plate. In two other experimental groups, we transplanted autogenous fat tissue into the same defects, or left them empty. Histological and radiographic examinations were done before and after transplantation at various times up to 52 weeks postoperatively. The histological study showed that grafted chondrocytes synthesized extracellular matrix and prevented early ossification and closure of the growth plate, which occurred in the Fat and Defect groups. Angular deformity and length discrepancy in the transplanted group were less than in the control group. Our findings suggest that transplantation of autogenous chondrocytes, cultured in atelocollagen gel, may improve treatment of the injured growth plate.
