ABSTRACT
BACKGROUND AND AIMS: Schistosomiasis is a major chronic disease of humans in endemic regions, and infected individuals may develop a spectrum of pathology, including hepatic fibrosis, hepatosplenomegaly, and portal hypertension. Hepatocellular carcinoma (HCC) is considered the fifth most common cancer in the world, and there is limited and controversial evidence suggesting that Schistosoma mansoni infection may be a possible risk factor for HCC. The aim of this study was to report a case series of patients with HCC and S. mansoni infection and to conduct a literature review on the topic. METHODS: From January 2002 to January 2015, an institutional database was screened retrospectively to identify patients with HCC and S. mansoni infection at a single center in the Department of Gastroenterology of University of São Paulo School of Medicine and Hospital das Clínicas, Brazil. RESULTS: Seven cases were included. The mean age of patients was 62.1±10.3 years; six (85.7%) were male and one (14.3%) was female. All cases had positive epidemiology, coming from endemic areas of S. mansoni infection in Brazil, and four (57.1%) had previous complications (upper gastrointestinal bleeding) related to portal hypertension or surgery intervention (splenectomy) performed more than 10 years before the HCC diagnosis. Nontumoral portal vein thrombosis was identified in five (71.4%) patients. All patients had negative serology for HCV, and four (57.1%) had positivity of HBVcore antibodies without evidence of viral replication. According to BCLC staging, one (14.3%) patient was BCLC A and received TACE instead of RFA because HCC size was >30 mm; three (42.8%) BCLC B patients received sorafenib instead of local regional treatment due to the presence of nontumoral TPV. During follow-up, all patients developed tumoral progression and died. CONCLUSIONS: It remains unclear if S. mansoni infection alone has carcinogenic potential. The available literature indicates that S. Mansoni, in the presence of HBV and HCV infections, likely acts as a cofactor for the hepatic lesion and potentiates injury.
ABSTRACT
Objetivo: verificar a prevalência de hipertensão arterial sistêmica HAS em pacientes diabéticos do ambulatório de Endocrinologia do Hospital Universitário João de Barros Barreto em 2003. Método: eSllIdo transversal envolvendo cento e noventa e oito (198) prontuários de pacientes diabéticos com HAS, selecionados de forma randomizada, com aplicação de ficha de protocolo para a coleta de dado. Resultados: dos 198 pacientes estudados, 66,7% eram do sexo feminino, 51,0%, pardos, predominando afaixa etária acima de 60 anos (57,6%); a prevalência de HAS foi de 55,5%. Conclusão: a HAS alimenta de forma substancial o risco de complicações diabéticas macro e microvasculares, tomando-se fundamental a instituição de adequado manejo e tratamento para o controle desta nosologia.
Objective: to verify the prevalence of hypertension in diabetics patientes that were attended in tht endocrillology ambulatory from" Hospital Universitário Joao de Barros Barreto" in 2003. Method: a transversal study of prevalence based ond data collected by the Departament of Statistics and Medical Archives of tlle hospital. One hundred ninety eight (198) patients were randomly selected. Results:of the /98 patients studied, 66.7% were female and 51.0% brown, mainly the age above 60 years (57.6%). The prevalence of hypertension was 55.5%. Conclusion: The hypertension increases a substantial risk of the macro and microvascular diabetic complications, becoming fundamental the institution of proper management and treatment to control this disease.
