[Prenatal diagnosis using chorionic biopsy in the 1st trimester of pregnancy]. / Antenatalna dijagnostika horionom biopsijom u I trimestru trudnoce.

One hundred-sixteen pregnant women were subjected to chorionic villi sampling at the gestational age of 8-11 weeks. In 12 cases, the transabdominal approach was used, and in the rest of the cases, a flexible catheter was placed transcervically. The most frequent indication was the age of the pregnant women (over 35). Chorionic villi sampling was successfully performed in 97.5% of cases. Fetal loss amounted to 1.9%.

[Early diagnosis of malignant tumors of the the ovary using ultrasound]. / Ranija dijagnostika malignih tumora ovarija pomocu ultrazvuka.

On Gynecology-Obstetric Clinic in Sarajevo in 100 women, aged 22-80, was made the indication for laparotomy because of the changes on ovaries and it was done according to the palpatory, ultrasound and laparoscopic examination. After the operative treatment and pathologic verification from the 100 studied tumors were found 15 (15%) carcinous cystadenoma, 2 (2%) mucinous cystadenocarcinoma, 25 (25%) serous cystadenoma, 10 (10%) serous cystadenocarcinoma, 10 (10%) adenocarcinoma, 23 (23%) teratoma and 13 (13%) tumors of the other kind, 25 (25%) of tumors were malign and 75 (75%) was benign. The predicted value of the ultrasoundly proved malignity was 80% (20 from 25 patients) and for the benign tumors it was 96% (72 from 75 patients). Malignant tumor of ovary is the third most common malignant disease of genital organs of a woman and at the same time the most often cause of death of women suffering from gynecologic malignant diseases. From all kinds of gynecologic malignant tumors 25% are carcinoma of ovaries. It is the cause of death in 47% women with the malignant diseases of genital organs. The bad prognosis of this tumor is mostly caused by the late diagnosis. Patients most often do not feel any disturbances until the illness comes to the phase of methastase and the most of patients (60-70%) at the time of diagnosis is already in the III or IV stage of illness.

[Obstetrical approach in prenatal diagnosis in the first and second trimester of pregnancy]. / Akuserski postupci antenatalne dijagnostike u prvom i drugom trimestru trudnoce.

From 712 women-patients in Genetic Consultation Department 284 of them were submitted to antenatal diagnostics. The most common indications were old age of pregnant women or a malformed child in the previous pregnancies or in the family. Horion biopsy was done in 118 patients and amniocentesis was performed in the I and II trimester of pregnancy in 188 of them. The fetal loss according to the weeks of pregnancy in the groups, where was done the antenatal diagnostic treatment was not significantly different from horion biopsy was 1.9% and the success of cultivating of horion tissue was 98%. The findings of chromosome analysis were confirmed in all cases.