[Level of estrogen receptors in breast tumors: role of ethnic factors]. / Soderzhanie retseptorov éstrogenov v opukholiakh molochnoi zhelezy: rol' éthnicheskikh faktorov.

Estrogen receptor levels have been assayed in breast cancer patients. A significant increase in receptor-negative tumors was found in Kazakh menopausal women. The proportion of receptor-positive tumors correlated inversely with tumor progression, irrespective of ethnicity. A significant rise in the incidence of receptor-negative tumors was recorded in Kazakh females with breast cancer stage III.

[Hormonal and immunological changes in breast cancers with different growth rates]. / Gormonal'nye i immunologicheskie izmeneniia pri rake molochnoi zhelezy s razlichnoi skorost'iu rosta.

Thirty-four breast carcinomas revealed unequal growth rates their doubling time ranging 12-150 days. Steroid hormone levels and immunologic vigor were found to significantly differ in patients with different growth rates. Higher rates were associated with more pronounced systemic disorders.

[Adrenal cortical function, immunological reactivity and the blood serum cholesterol level of esophageal cancer patients]. / Funktsiia kory nadpochechnikov, immunologicheskaia reaktivnost' i uroven' kholesterina syvorotki krovi u bol'nykh rakom pishchevoda.

Functional status of the adrenal cortex was studied in 80 patients (aged 31-70) suffering esophageal cancer (predominantly stage III). Blood serum showed high levels of cortisol and 11-HCS and a decrease in those of 17-HCS and 17-KS. Groups with hypo-, normo- and hypercholesterolemia were formed. Lowered blood-cholesterol levels were more frequent in cancer patients as compared to healthy subjects. Cases under study revealed decreased immunologic vigor. A peak concentration of cortisol was matched by a decrease in E-RFC level and a sharp drop in that of blood serum cholesterol. Combined chemoradiation treatment partially brought glucocorticoid and 17-KS levels to normal but did not affect cell-mediated immunity. Complex immunocorrection and chemoradiation treatment normalized hormonal function and immunologic indexes.

[Level of steroid and tropic pituitary hormones in the blood of patients with breast cancer treated with tamoxifen]. / Uroven' steroidnykh i nekotorykh tropnykh gormonov gipofiza v syvorotke krovi u bol'nykh rakom molochnoi zhelezy pri lechenii tamoksifenom.

A radioimmunologic assay of steroid and tropic hormones levels in blood serum was carried out in 30 breast cancer patients receiving tamoxifen. Long-term treatment with tamoxifen was followed by a significant decrease in blood-estradiol, progesterone, testosterone and prolactin levels whereas FSH, LH and hydrocortisone concentrations remained virtually unchanged.

[Mediated action of phytogenic antineoplastic agents on rats with Pliss lymphosarcoma]. / Oposredovannoe deistvie nekotorykh protivoopukholevykh preparatov rastitel'nogo proiskhozhdeniia na krys s limfosarkomoi Plissa.

The action of drugs of plant origin and of alkylating compounds (sarcolysine, prospidin) was accompanied by hormonal changes in rats with inoculated Pliss' lymphosarcoma. After the use of polyphenol plant drugs the secretion of pituitary FSH was inhibited, the blood concentration of testosterone was reduced and the cortisol secretion was substantially increased. The alkylating compounds stimulated the production of FSH, increased the secretion of testosterone, and clearly lowered the cortisol level.