ABSTRACT
38 patients with advanced breast adenocarcinoma were treated in a phase II study with 5-fluorouracil and high-dose folinic acid combined with cyclophosphamide and mitoxantrone. 6 patients had received prior chemotherapy for advanced disease, all with an anthracycline-containing regimen. Treatment was generally well tolerated. The most common side-effect was myelosuppression, with 1 toxic death due to leukopenia-related sepsis. 1 patient developed severe congestive heart failure 12 months from the end of therapy. 36 patients were evaluable for response. The overall response rate was 55%. Median duration of response was 8 months and median survival time was 16 months. This regimen warrants further investigations.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Breast Neoplasms/drug therapy , Adult , Aged , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Cyclophosphamide/administration & dosage , Drug Evaluation , Female , Fluorouracil/administration & dosage , Heart Failure/chemically induced , Humans , Leucovorin/administration & dosage , Leukopenia/chemically induced , Middle Aged , Mitoxantrone/administration & dosage , Salvage Therapy , Thrombocytopenia/chemically inducedABSTRACT
Two case reports and review of the literature. The authors describe one case of primary lymphoma and one case of secondary lymphoma of the bladder. They evaluate the differences, underline the rarity of the primitive type and make a review of the literature.
Subject(s)
Lymphoma , Urinary Bladder Neoplasms , Aged , Aged, 80 and over , Diagnosis, Differential , Female , Humans , Lymphoma/diagnosis , Lymphoma, B-Cell/diagnosis , Middle Aged , Urinary Bladder Neoplasms/diagnosis , Urinary Bladder Neoplasms/secondaryABSTRACT
The authors describe two cases of nasopharynx and oropharynx carcinomas in treated non-Hodgkin lymphoma's patients. They evaluate pathogenetic hypotheses related to lymphoma, its treatment and some exogenous factors like smoke, alcohol, Epstein-Barr virus.
