1.
Bioorg Med Chem Lett
; 22(14): 4762-4, 2012 Jul 15.
Article
in English
| MEDLINE
| ID: mdl-22727670
ABSTRACT
We synthesized calothrixin B using our developed biomimetic method and derived N-alkyl-calothrixins A and B. The in vitro antimalarial activity of the calothrixin derivatives, including calothrixins A and B, against the Plasmodium falciparum FCR-3 strain was evaluated. All test compounds exhibited antimalarial activity over a concentration range of 6.4×10(-6)-1.2×10(-7) M.