ABSTRACT
Epilepsy typology and some factors influencing polymorphism of epilepsy course are presented. The analysis of the results of entire clinical and epidemiological study conducted in patients with epilepsy from community settings of Jewish autonomy region was undertaken. Among 547 cases examined, the course type was determined in 502 patients. A contribution of constitutional and genetic factors was studied. Factors influencing, to a certain extent, the course type of epilepsy, i.e. sex, childhood speech disorders, psychomotor development delay, epileptic-like traits in premorbid adjustment, presence of postnatal complications, age at the disease onset, were detected. At the same time, such factors as antenatal and perinatal complications, presence of convulsing and nonconvulsing childhood paroxysmal states in epilepsy patient's anamnesis, positive family history of the disease, do not affect the disease course. The data obtained may be used for prognosis of early disease stages and during clinical examination of the patients.
Subject(s)
Epilepsy/epidemiology , Epilepsy/physiopathology , Child , Disease Progression , Electroencephalography , Epilepsy/diagnosis , Female , Humans , Male , Severity of Illness Index , Surveys and Questionnaires , Time FactorsABSTRACT
In Jewish Autonomous Province an investigation of epilepsy was performed, including all the patients that lived on this territory. 547 epileptic patients were defected, that was 2.9 cases per 1000 of the population. Estimation of the patients was performed using 65 standard signs. The data were received concerning prevalence of epilepsy in the region, sex-age structure of the patients, clinical manifestations of the disease and other parameters. Special attention was paid to clinical-genetic aspects of epilepsy. The data received are important for carrying out a clinical examination and for differential rehabilitation of the patients, for planning medical prophylaxis measures as well as for medical-genetic consultative service.
Subject(s)
Epilepsy/ethnology , Jews/statistics & numerical data , Adolescent , Adult , Age Distribution , Aged , Aged, 80 and over , Child , Child, Preschool , Epilepsy/diagnosis , Epilepsy/genetics , Female , Humans , Male , Middle Aged , Prevalence , Rural Population/statistics & numerical data , Sex Distribution , Siberia/epidemiology , Urban Population/statistics & numerical dataABSTRACT
The authors compare the factors, parameters and typology of the clinical polymorphism of epilepsy in two groups of patients from an epidemiological sample: 265 patients with a synchronous and 251 patients with an asynchronous circadian pattern of attacks. It has been found that the asynchronous circadian pattern of attacks significantly correlated with a belated psychomotor development, hyperexcitability premorbid characteristics, convulsive manifestations of the disease, marked changes in the personality, the progressive type of the disease course and a number of other unfavourable signs.
Subject(s)
Circadian Rhythm , Epilepsy/physiopathology , Epilepsy/diagnosis , Epilepsy/epidemiology , Humans , Personality , Social AdjustmentABSTRACT
With the help of genetic-dispersion analysis the authors studied a series of phenotypes, using both their own familial records (232 families, 5060 relatives of the I-III degree of kinship) as well as those of other researchers (570 families, 18415 relatives of the I-III degree of kinship). The results have shown that the contribution of the genetic and environmental factors to the determination of epilepsy constitutes 5% and 95% in the alternative phenotype model and 65% and 35% in the quasi-continuous phenotype model, respectively. The degree of the genetic factors involvement in the development of phenotypes of "genuine" and "centroencephalic" epilepsy increases irrespective of the phenotype model. The authors also present their outlook on further developments of the genetic dispersion analysis in the research of multifactorial mental diseases.
