ABSTRACT
In the period of the most expressed postirradiation (4 Gy) injury, the rats secreted volatile components capable of lowering the blood cells count in intact rats. This ability of the irradiated animals is not strictly specific for species since the depression effect on rats is exerted also by volatile components of irradiated mice. We suggest marking this phenomenon as postirradiation allelopathy.
Subject(s)
Radiation Injuries, Experimental/urine , X-Rays , Animals , Blood Cell Count , Female , Radiation Injuries, Experimental/blood , Rats , Rats, Wistar , VolatilizationSubject(s)
Metronidazole/therapeutic use , Radiation Injuries, Experimental/prevention & control , Radiation Injuries/prevention & control , Animals , Combined Modality Therapy , Drug Evaluation , Drug Evaluation, Preclinical , Female , Male , Radiation Injuries/epidemiology , Radiation Injuries/etiology , Radiation Injuries, Experimental/etiology , Radiotherapy Dosage , Rats , Rats, Wistar , Retrospective Studies , Time Factors , Uterine Cervical Neoplasms/complications , Uterine Cervical Neoplasms/radiotherapyABSTRACT
The use of small doses of metronidazole (90 mg/kg) for 7 days followed by irradiation of the rat hip at a dose of 66 Gy, increased 1.7 times cicatrization at the site of radiation injuries in comparison with the control group of animals.
Subject(s)
Metronidazole/therapeutic use , Radiation Injuries, Experimental/prevention & control , Radiation-Protective Agents/therapeutic use , Animals , Male , Rats , Rats, Inbred StrainsABSTRACT
Gas hypoxic mixture (GHM-10) decreased significantly the occurrence and duration of radioepidermitis after local therapeutic fractionated irradiation of Wistar rat skin with a cumulative dose of 66 Gy. In patients subjected to radiation therapy and protected with GHM-10 erythema and epidermitis developed at a much higher cumulative dose than in the controls. With erythema dose modifying coefficient was 1.38 +/- 0.06.