ABSTRACT
Diabetic foot infections, a frequent and serious cause of morbidity in patients with diabetes mellitus, are caused by anaerobic and aerobic bacteria. Given the fact that seriously impaired host defense factors are almost always present in these patients, bactericidal agents with a broad spectrum of antimicrobial activity are required for their treatment. Seventy-four patients with diabetic foot infections were treated with parenteral sulbactam-ampicillin (1.5 g, q.i.d.). All patients were followed-up prospectively in order to determine the efficacy and safety of sulbactam-ampicillin. The mean duration (+/- SD) of treatment in patients with osteomyelitis (n = 49) and soft tissue infections (n = 25) was 41 +/- 5 and 14 +/- 3 days, respectively. Infected limbs were amputated at various levels in 14 patients (19%). Clinical cure rates were 86% and 100% in patients with osteomyelitis and with soft tissue infection, respectively. The most frequent side effect was diarrhea and observed in 10 patients (14%). The results of the present study indicate that sulbactam-ampicillin is safe and effective in the treatment of diabetic foot infections.
Subject(s)
Ampicillin/therapeutic use , Bacterial Infections/drug therapy , Diabetic Foot/complications , Drug Therapy, Combination/therapeutic use , Enzyme Inhibitors/therapeutic use , Sulbactam/therapeutic use , Adult , Aged , Aged, 80 and over , Ampicillin/adverse effects , Bacterial Infections/complications , Drug Therapy, Combination/adverse effects , Evaluation Studies as Topic , Female , Gram-Negative Bacteria/drug effects , Gram-Positive Bacteria/drug effects , Humans , Male , Microbial Sensitivity Tests , Middle Aged , Prospective Studies , Sulbactam/adverse effects , Treatment Outcome , beta-Lactamase InhibitorsABSTRACT
Primary lymphangioma is a disease of unknown aetiology in which lytic lesions occur in the long bones, pelvis, spine and skull. A case in a girl, 4 years of age, is presented.
