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1.
Bone Joint J ; 99-B(11): 1467-1476, 2017 Nov.
Article in English | MEDLINE | ID: mdl-29092985

ABSTRACT

AIMS: The optimal method of tibial component fixation remains uncertain in total knee arthroplasty (TKA). Hydroxyapatite coatings have been applied to improve bone ingrowth in uncemented designs, but may only coat the directly accessible surface. As peri-apatite (PA) is solution deposited, this may increase the coverage of the implant surface and thereby fixation. We assessed the tibial component fixation of uncemented PA-coated TKAs versus cemented TKAs. PATIENTS AND METHODS: Patients were randomised to PA-coated or cemented TKAs. In 60 patients (30 in each group), radiostereometric analysis of tibial component migration was evaluated as the primary outcome at baseline, three months post-operatively and at one, two and five years. A linear mixed-effects model was used to analyse the repeated measurements. RESULTS: After five years of follow-up, one (cemented) component was revised due to ligament instability. Overall, uncemented PA-coated tibial components migrated significantly more (p = 0.003), with the mean maximum total point motion (MTPM) at five years being 0.62 mm (95% confidence intervals (CI) 0.49 to 0.76) for cemented tibial components and 0.97 mm (95% CI 0.81 to 1.15) for PA-coated tibial components in TKA. However, between three months and five years the cemented TKAs migrated significantly more (p = 0.02), displaying a MTPM of 0.27 mm (95% CI, 0.19 to 0.36) versus 0.13 mm (95% CI, 0.01 to 0.25) for PA-coated tibial components. One implant in each group was considered at risk for aseptic loosening due to continuous migration after five years of follow-up, albeit with different migration patterns for each group (i.e. higher initial migration but diminishing over time for the PA-coated component versus gradually increasing migration for the cemented component). CONCLUSION: The tibial components of PA-coated TKAs showed more overall migration compared with the tibial components of cemented TKAs. However, post hoc analysis showed that this difference was caused by higher migration of PA-coated components in the first three months, after which a stable migration pattern was observed. Clinically, there was no significant difference in outcome between the groups. Cite this article: Bone Joint J 2017;99-B:1467-76.


Subject(s)
Apatites , Arthroplasty, Replacement, Knee/instrumentation , Bone Cements , Coated Materials, Biocompatible , Knee Prosthesis , Osteoarthritis, Knee/surgery , Prosthesis Failure , Adult , Aged , Female , Follow-Up Studies , Humans , Linear Models , Male , Middle Aged , Osteoarthritis, Knee/diagnostic imaging , Radiostereometric Analysis , Treatment Outcome
3.
Acta Anaesthesiol Scand ; 59(3): 298-309, 2015 Mar.
Article in English | MEDLINE | ID: mdl-25522681

ABSTRACT

BACKGROUND: The choice of anaesthetic technique for patients undergoing joint arthroplasty is debatable. The hypothesis of this study was that general anaesthesia would generate a more favourable recovery profile than spinal anaesthesia. METHODS: We randomly allocated 120 patients to either intrathecal bupivacaine or general anaesthesia with target-controlled infusion of remifentanil and propofol. Length of hospital stay assessed as meeting discharge criteria was the primary outcome parameter. Other outcome parameters were actual time of discharge, pain, use of rescue pain medication, blood loss, length of stay in the post-operative care unit, dizziness, post-operative nausea, need of urinary catheterisation and patient satisfaction. RESULTS: General anaesthesia resulted in slightly reduced length of hospital stay (26 vs. 30 h, P = 0.004), less nausea (P = 0.043) and dizziness (P < 0.001). General anaesthesia patients had higher pain scores during the first two post-operative hours (P < 0.001) but lower after 6 h compared with the spinal anaesthesia group (P < 0.01 and P < 0.05). General anaesthesia patients had better orthostatic function compared with spinal anaesthesia patients (P = 0.008). Patients in the spinal anaesthesia group fulfilled the discharge criteria from the post-operative care unit earlier compared with the general anaesthesia patients (P = 0.004). General anaesthesia patients requested a change in the method of anaesthesia for a subsequent operation less often than the spinal anaesthesia patients (5 vs. 13, P = 0.022). CONCLUSION: General anaesthesia resulted in a more favourable recovery profile compared with spinal anaesthesia.


Subject(s)
Anesthesia, General/methods , Anesthesia, Spinal/methods , Aged , Anesthesia, Intravenous , Anesthetics, Intravenous , Anesthetics, Local , Arthroplasty, Replacement, Hip , Bupivacaine , Female , Humans , Length of Stay/statistics & numerical data , Male , Patient Satisfaction , Piperidines , Postoperative Complications/prevention & control , Prospective Studies , Remifentanil
4.
Br J Anaesth ; 111(3): 391-9, 2013 Sep.
Article in English | MEDLINE | ID: mdl-23578860

ABSTRACT

BACKGROUND: This study was undertaken to compare the effects of general anaesthesia (GA) and spinal anaesthesia (SA) on the need for postoperative hospitalization and early postoperative comfort in patients undergoing fast-track total knee arthroplasty (TKA). METHODS: One hundred and twenty subjects were randomly allocated to receive either intrathecal bupivacaine (SA group) or GA with target controlled infusion of propofol and remifentanil (GA group). Primary outcome was length of hospital stay (LOS) defined as time from end of surgery until the subject met the hospital discharge criteria. Secondary outcome parameters included actual time of discharge, postoperative pain, intraoperative blood loss, length of stay in the Post Anaesthesia Care Unit, dizziness, postoperative nausea and vomiting, need for urinary catheterization and subject satisfaction. RESULTS: GA resulted in shorter LOS (46 vs 52 h, P<0.001), and less nausea and vomiting (4 vs 15, P<0.05) and dizziness (VAS 0 mm vs 20 mm, P<0.05) compared with SA. During the first 2 postoperative hours, GA patients had higher pain scores (P<0.001), but after 6 h the SA group had significantly higher pain scores (P<0.001). Subjects in the GA group used fewer patient-controlled analgesia doses and less morphine (P<0.01), and were able to walk earlier compared with the SA group (P<0.001). Subjects receiving SA would request a change in the method of anaesthesia in the event of a subsequent operation more often than the GA subjects (P<0.05). CONCLUSION: GA had more favourable recovery effects after TKA compared with SA.


Subject(s)
Anesthesia Recovery Period , Anesthesia, General/methods , Anesthesia, Spinal/methods , Arthroplasty, Replacement, Knee/methods , Length of Stay/statistics & numerical data , Postoperative Complications/epidemiology , Aged , Anesthesia, General/statistics & numerical data , Anesthesia, Intravenous , Anesthesia, Local , Anesthesia, Spinal/statistics & numerical data , Bupivacaine , Female , Humans , Male , Patient Satisfaction/statistics & numerical data , Piperidines , Propofol , Remifentanil , Sweden/epidemiology
5.
Bone Joint Res ; 1(12): 315-23, 2012 Dec.
Article in English | MEDLINE | ID: mdl-23610663

ABSTRACT

OBJECTIVES: The objective of this study was to compare the early migration characteristics and functional outcome of the Triathlon cemented knee prosthesis with its predecessor, the Duracon cemented knee prosthesis (both Stryker). METHODS: A total 60 patients were prospectively randomised and tibial component migration was measured by radiostereometric analysis (RSA) at three months, one year and two years; clinical outcome was measured by the American Knee Society score and the Knee Osteoarthritis and Injury Outcome Score. RESULTS: There were no statistically significant differences in rotation or translation around or along the three coordinal axes, or in the maximum total point motion (MTPM) during the two-year follow-up. CONCLUSIONS: The Triathlon cemented knee prosthesis has similar early stability and is likely to perform at least as well as the Duracon cemented knee prosthesis over the longer term.

6.
Osteoarthritis Cartilage ; 17(5): 601-6, 2009 May.
Article in English | MEDLINE | ID: mdl-19091604

ABSTRACT

OBJECTIVE: To prospectively describe self-reported outcomes up to 5 years after total knee replacement (TKR) in Osteoarthritis (OA) and to study which patient-relevant factors may predict outcomes for pain and physical function (PF). METHODS: 102 consecutive patients with knee OA, 63 women and 39 men, mean age 71 (51-86) assigned for TKR at the Department of Orthopaedics at Lund University Hospital were included in the study. The self-administered questionnaires Knee injury and Osteoarthritis Outcome Score (KOOS) and SF-36 were mailed preoperatively and 6 months, 12 months and at 5 years postoperatively. RESULTS: Response rate at 5 years was 86%. At 6 months significant improvement was seen in all KOOS and SF-36 scores (P<0.001). The percentage of patients performing more demanding functions related to sports and recreation increased postoperatively. The best postoperative result was reported at the 1 year follow-up. Compared to the 1 year follow-up, a significant (P

Subject(s)
Arthroplasty, Replacement, Knee/standards , Osteoarthritis, Knee/physiopathology , Pain/physiopathology , Patient Satisfaction/statistics & numerical data , Activities of Daily Living , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Osteoarthritis, Knee/surgery , Pain/surgery , Prospective Studies , Surveys and Questionnaires , Time Factors , Treatment Outcome
7.
Cancer Genet Cytogenet ; 131(1): 19-24, 2001 Nov.
Article in English | MEDLINE | ID: mdl-11734313

ABSTRACT

Osteoarthritis (OA) and pigmented villonodular synovitis (PVNS) are disorders associated with trisomy 7. The aim of the present study was to determine the frequency and distribution of the cells with +7 in vivo by analyzing sections of paraffin-embedded synovia from patients affected by OA, PVNS, other forms of synovitis [hemorragic synovitis (HS) and chronic synovitis (CS)], and from individuals without joint disease. Fluorescence in situ hybridization (FISH), using a centromeric probe for chromosome 7, showed that the mean frequency of trisomic nuclei in 5-microm sections was highest in PVNS (9.0%), followed by CS (5.9%), OA (5.6%), and HS (4.6%), whereas trisomic nuclei were rare (0.7%) in normal tissue. When 8-microm sections were studied, the frequencies of trisomic cells in OA and control synovia increased to 6.7% and 1.5%, respectively. Trisomic nuclei were found in all cases, including those for which cytogenetic analysis of short-term cultures had not disclosed any trisomic cells. Overall, the trisomic cells were scattered within the tissue. However, small clusters of cells with +7 were found in three cases. By hematoxylin-eosin staining of the slides used for FISH analysis it could be shown that the clustered trisomic cells were proliferating synoviocytes within villous extensions of the synovial membrane.


Subject(s)
Chromosomes, Human, Pair 7/genetics , Osteoarthritis/genetics , Synovial Fluid/metabolism , Synovitis, Pigmented Villonodular/genetics , Trisomy/genetics , Adult , Aged , Aged, 80 and over , Cell Count , Data Interpretation, Statistical , Female , Humans , In Situ Hybridization, Fluorescence , Karyotyping , Male , Middle Aged , Osteoarthritis/pathology , Synovitis, Pigmented Villonodular/pathology
8.
Clin Orthop Relat Res ; (388): 209-17, 2001 Jul.
Article in English | MEDLINE | ID: mdl-11451122

ABSTRACT

In a multicenter, prospective, randomized study, the biomechanical and clinical properties of the bone-pin interface were compared with standard tapered pins and hydroxyapatite-coated tapered pins implanted in patients who underwent femoral and tibial external fixation treatments. The results showed that the hydroxyapatite-coated tapered pins are clinically effective in improving the strength of fixation of the bonepin interface. This improvement corresponded to a lower rate of pin tract infection. In the hydroxyapatite-coated pin group, there were no differences in strength of fixation between the pins removed from the infected and uninfected pin tracts. In this pin group, the mean pin extraction torque was 531 +/- 225 Ncm in the infected pin tracts and 508 +/- 233 Ncm in the uninfected pin tracts. In the standard pin group, the mean pin extraction torque was 73 +/- 142 Ncm in the infected pin tracts and 211 +/- 216 Ncm in the uninfected pin tracts. The advantages provided by the hydroxyapatite-coated pins were higher in cancellous bone than in cortical bone.


Subject(s)
Bone Nails , Coated Materials, Biocompatible , Durapatite , Femoral Fractures/surgery , Prosthesis-Related Infections/prevention & control , Tibial Fractures/surgery , Adult , Biomechanical Phenomena , Humans , Middle Aged , Prospective Studies , Prosthesis Design
9.
Knee Surg Sports Traumatol Arthrosc ; 9 Suppl 1: S21-3, 2001.
Article in English | MEDLINE | ID: mdl-11354863

ABSTRACT

Data from the Swedish Knee Arthroplasty Registry were analyzed to compare bi- and tricompartmental knee arthroplasties carried out in patients operated on for arthrosis in 1990-1996. Of the 16,607 primary arthroplasties that were carried out there were 5,139 with patellar replacement in the primary procedure and 10,928 without. By April 1998, 280 revisions were performed, 250 of these cases were analyzed in this study. Patella-related complications were commonly the reason for early revision: in 99 of the 168 knees with a primary bicompartmental procedure and in 36 of the 82 knees with a primary tricompartmental procedure. This presentation merely analyzes the extent of patellar problems in knee arthroplasty, as a detailed analysis of the causes of this common problem is not possible using data from a national multicenter study.


Subject(s)
Arthroplasty, Replacement, Knee/methods , Patella/surgery , Arthroplasty, Replacement, Knee/statistics & numerical data , Female , Humans , Knee Prosthesis/adverse effects , Male , Prosthesis Failure , Registries , Reoperation/statistics & numerical data , Sweden , Time Factors
10.
Mod Pathol ; 14(4): 311-7, 2001 Apr.
Article in English | MEDLINE | ID: mdl-11301347

ABSTRACT

Chromosomal rearrangements involving chromosome bands 12q13-15 are very frequent findings in benign solid tumors, and recently, the primary molecular target for these aberrations was identified as the gene HMGIC. However, mutations in this gene have also been observed in nonneoplastic tissues. In a previous study, we reported breakpoints within HMGIC of synovia affected by osteoarthritis (OA) in two cases with 12q15 aberrations. To analyze further the role of HMGIC in this disease, we have performed cytogenetic, fluorescent in situ hybridization (FISH), RNA, and protein expression analyses on synovial samples from patients with OA and individuals without signs of the disorder. Cytogenetic analysis of short-term cultured cells revealed clonal 12q13-15 aberrations in 2/36 cases of OA synovia and no rearrangement in any of the five controls. With FISH analysis, it was shown that the chromosomal breakpoints in the two aberrant cases were located outside the HMGIC locus. In contrast, at RNA and protein expression analyses, OA-affected as well as normal synovia displayed transcription and translation of the gene. We also analyzed whether immunoreactivity for HMGIC was associated with the proliferation-specific antigen Ki-67, but no correlation between the staining patterns of these proteins was observed. From the results of the present study, it is evident that expression of HMGIC cannot simply be considered a sign of neoplasia or an effect of proliferation.


Subject(s)
High Mobility Group Proteins/genetics , Nuclear Proteins/genetics , Osteoarthritis/genetics , Synovial Membrane/metabolism , Adolescent , Adult , Aged , Aged, 80 and over , Cell Count , Cells, Cultured , Chromosomes, Human, Pair 12 , DNA Primers/chemistry , HMGA2 Protein , High Mobility Group Proteins/metabolism , Humans , Immunoenzyme Techniques , In Situ Hybridization, Fluorescence , Karyotyping , Ki-67 Antigen/metabolism , Middle Aged , Molecular Sequence Data , Nuclear Proteins/metabolism , Osteoarthritis/metabolism , RNA/isolation & purification , Reverse Transcriptase Polymerase Chain Reaction , Synovial Membrane/pathology , Translocation, Genetic
11.
Genes Chromosomes Cancer ; 30(3): 310-5, 2001 Mar.
Article in English | MEDLINE | ID: mdl-11170291

ABSTRACT

Trisomy 7 is a common finding in benign and malignant solid tumors, in several non-neoplastic lesions (for example, osteoarthritis and rheumatoid arthritis), and in apparently normal tissues as well, suggesting that the occurrence of +7 might be associated with factors other than the disease process itself. To find out whether the frequency of +7 varies with a patient's age, we cytogenetically analyzed short-term-cultured synovial samples from elderly persons without signs of arthritis and from young patients affected by juvenile chronic arthritis (JCA). In normal synovia, gain of a chromosome 7 was present as a clonal change in five of 10 cases and in single cells in four of the five remaining cases. In synovia from patients with JCA, cells with +7 were detected in only one of nine cases, representing the oldest patient in the series. Furthermore, we reviewed the cytogenetic literature on tumors of the brain, breast, colon, kidney, lung, skin, thyroid, and upper aerodigestive tract. In the majority (six of eight) of these tumor types, the frequency of cases displaying a clone with +7 as the sole aberration increased with age. Taken together, the results presented here suggest that the acquisition of trisomy 7 in some neoplastic and non-neoplastic tissues might be associated with age rather than with disease. The finding of a completely different frequency distribution in two of the tumor types (tumors of the brain and the thyroid gland), however, emphasizes the heterogeneity of +7 and indicates that other, possibly tissue-specific, factors might influence the occurrence of this mutation.


Subject(s)
Aging/genetics , Chromosomes, Human, Pair 7/genetics , Neoplasms/genetics , Synovial Fluid/metabolism , Trisomy/genetics , Adolescent , Adult , Aged , Aged, 80 and over , Arthritis, Juvenile/genetics , Child , Female , Humans , Karyotyping , Male , Osteoarthritis/genetics
12.
J Biomech ; 33(12): 1593-9, 2000 Dec.
Article in English | MEDLINE | ID: mdl-11006383

ABSTRACT

The accuracy of digital Roentgen stereophotogrammetric analysis (RSA) was compared to the accuracy of a manually operated RSA system. For this purpose, we used radiographs of a phantom and radiographs of patients. The radiographs of the patients consisted of double examinations of 12 patients that had a tibial osteotomy and of double examinations of 12 patients that received a total hip prosthesis. First, the radiographs were measured manually with an accurate measurement table. Subsequently, the images were digitized by a film scanner at 150 DPI and 300 DPI resolutions and analyzed with the RSA-CMS software. In the phantom experiment, the manually operated system produced significantly better results than the digital system, although the maximum difference between the median values of the manually operated system and the digital system was as low as 0.013mm for translations and 0.033 degrees for rotations. In the radiographs of the patients, the manually operated system and the digital system produced equally accurate results: no significant differences in translations and rotations were found. We conclude that digital RSA is an accurate, fast, and user friendly alternative for manually operated RSA. Currently, digital RSA systems are being used in a growing number of clinical RSA-studies.


Subject(s)
Bone and Bones/diagnostic imaging , Diagnosis, Computer-Assisted , Photogrammetry , Arthroplasty, Replacement, Hip , Automation , Humans , Osteotomy , Phantoms, Imaging , Radiography , Tibia/diagnostic imaging , Tibia/surgery
13.
J Arthroplasty ; 15(5): 608-16, 2000 Aug.
Article in English | MEDLINE | ID: mdl-10960000

ABSTRACT

One hundred twenty-eight consecutive knees were operated on with the Duracon unicompartmental knee arthroplasty. Of 111 knees, followed 3 years (range, 1-6 years), 109 knees were satisfactory. Two knees were revised because of progression of osteoarthritis and inexplicable pain. Radiostereometric analysis in 49 knees showed a migration of 0.6 mm after 2 years. The magnitude of migration was lower in comparison with published series. In a multicenter study comprising 4 other hospitals, there were 8 revisions in 123 operated knees. The reasons were loosening, subsidence, or fracture. These revisions were within 1 year and mostly related to operative technique. Unicompartmental knee arthroplasty is a demanding procedure that needs special experience and includes a risk of early failures during the introduction of a system.


Subject(s)
Arthroplasty, Replacement, Knee/methods , Knee Prosthesis , Aged , Aged, 80 and over , Biomechanical Phenomena , Female , Follow-Up Studies , Humans , Male , Middle Aged , Patient Satisfaction , Prosthesis Design , Prosthesis Failure , Reoperation , Risk Factors , Time Factors
14.
Clin Orthop Relat Res ; (370): 192-200, 2000 Jan.
Article in English | MEDLINE | ID: mdl-10660713

ABSTRACT

Sixty-two knees (60 patients) were randomized to four noncemented groups. In Groups 1, 3, and 4, the bone cuts were made with a cooled saw blade. In Group 1, 15 patients were operated on with the porous coated Osteonic 7000 tibial component. In Group 2, 15 patients were operated on with the same tibial component as in Group 1 but with the use of a standard saw blade. In Group 3, 16 patients were operated on with the hydroxyapatite-coated Osteonic tibial component, and in Group 4, 16 patients were operated on with the hydroxyapatite Duracon tibial component. All patients were followed up clinically and with roentgenstereometric analysis. There were no differences among the groups regarding clinical outcome. One knee was revised (Group 2) after 1 year because of loosening of the tibial component. The maximum migration at 1 year was 1.7 mm in Group 1, 1.9 mm in Group 2, 1.3 mm in Group 3, and 1 mm in Group 4. At the 2-year followup, the migrations were 1.8 mm, 1.5 mm, 1.4 mm, and 1 mm in Groups 1, 2, 3, and 4, respectively. The inducible displacement that occurred at 1 year was 0.6 mm in Group 1, 0.5 mm in Group 2, 0.4 mm in Group 3, and 0.4 mm in Group 4. The hydroxyapatite coating had a strong positive effect on the tibial component fixation. No prosthesis in the hydroxyapatite groups showed continuous migration.


Subject(s)
Biocompatible Materials , Durapatite , Knee Prosthesis , Prosthesis Design/methods , Aged , Aged, 80 and over , Arthroplasty, Replacement, Knee/instrumentation , Arthroplasty, Replacement, Knee/methods , Arthroplasty, Replacement, Knee/statistics & numerical data , Female , Follow-Up Studies , Humans , Knee Joint/diagnostic imaging , Knee Joint/surgery , Knee Prosthesis/statistics & numerical data , Male , Middle Aged , Prosthesis Design/statistics & numerical data , Prosthesis Failure , Radiography , Tibia , Time Factors
15.
Acta Orthop Scand ; 71(6): 553-7, 2000 Dec.
Article in English | MEDLINE | ID: mdl-11145380

ABSTRACT

In a double-blind study, we randomized 50 patients to receive peroral clodronate medication or placebo from 3 weeks before until 6 months after a total knee replacement with a cemented NexGen implant. Migration of the tibial components was measured by radiostereometry at 1 year. Clodronate reduced prosthetic migration, as measured by maximum total point motion, from 0.40 mm to 0.29 mm (p = 0.01). This confirms that the early postoperative migration is related to bone resorption and thus the biology of the bone bed. Since early migration is related to late loosening, 6 months of clodronate medication might reduce the risk of loosening.


Subject(s)
Analgesics, Non-Narcotic/therapeutic use , Clodronic Acid/therapeutic use , Knee Prosthesis , Prosthesis Failure , Aged , Bone Resorption , Double-Blind Method , Humans , Middle Aged
16.
Acta Orthop Scand ; 70(4): 343-7, 1999 Aug.
Article in English | MEDLINE | ID: mdl-10569263

ABSTRACT

We investigated the working status during 2 years before and 2 years after primary knee prosthetic operation for arthrosis in order to identify preoperative factors predicting patient satisfaction, function and working capacity. 162 patients (86 women) younger than 60 years of age when operated on with a knee prosthesis during 1993 were studied. 91% of the patients returned a Nottingham Health Profile (NHP) questionnaire, and the Social Insurance Office could supply data on all patients. There was a positive association between the duration of pre- and postoperative sick-leave in the patients who returned to work. Preoperative sick-leave longer than 180 days increased the risk of postoperative disability pension, which was not found to be influenced by the grade of the work. Among the 52 patients who returned to work postoperatively, all 6 NHP functional categories were better in the patients with less than 180 days of preoperative sick-leave than in the patients with more than 180 days of preoperative sick-leave. The overall patient satisfaction was greater among patients who went back to work postoperatively. We conclude that long sick-leave before a knee prosthetic operation increases the risk of long postoperative sick-leave and disability pension and impairs the quality of life.


Subject(s)
Arthroplasty, Replacement, Knee/rehabilitation , Patient Satisfaction , Sick Leave , Arthritis/surgery , Disabled Persons , Female , Humans , Male , Middle Aged , Postoperative Period
17.
J Arthroplasty ; 14(5): 589-93, 1999 Aug.
Article in English | MEDLINE | ID: mdl-10475559

ABSTRACT

The prognosis of fixation in patients with total knee arthroplasty was classified as either good or poor based on migration results over 4 to 8 years using roentgen stereophotogrammetry. Gait analysis with the Vicon system was performed in 27 asymptomatic patients (1 bilateral), selected according to gender, implant design, age, and fixation principle to form two equivalent groups with different prognoses. The poor prognosis group walked with a predominantly flexing moment and higher moment peaks in the sagittal plane compared with the good prognosis group, in which moments were abnormally small. We conclude that individual gait patterns and subsequent differences in joint loading affect tibial component fixation.


Subject(s)
Gait , Knee Prosthesis , Prosthesis Failure , Aged , Aged, 80 and over , Female , Humans , Male , Photogrammetry , Tibia
18.
Genes Chromosomes Cancer ; 24(3): 278-82, 1999 Mar.
Article in English | MEDLINE | ID: mdl-10451709

ABSTRACT

The occurrence of clonal chromosome aberrations in short-term cultures from synovia, osteophytes, and cartilage from patients with osteoarthritis (OA) was recently reported. Among these aberrations, a recurrent involvement of chromosome bands 12q13-15 in structural rearrangements was detected in both synovia and osteophytes. Chromosomal abnormalities of 12q13-15 are frequent among malignant and benign mesenchymal tumors, and it was recently demonstrated that the molecular target in these neoplasms is the HMGIC gene. In this study, we show by fluorescence in situ hybridization that HMGIC was disrupted by rearrangements of 12q15 in synovia from two patients with OA. The finding of HMGIC rearrangement in a lesion that is not traditionally regarded as neoplastic not only widens the spectrum of disorders that may be associated with altered function of this gene, but also provides further support for the notion that genetically rearranged cell populations are part of the OA process.


Subject(s)
Chromosomes, Human, Pair 12/genetics , High Mobility Group Proteins/genetics , Neoplasm Proteins/genetics , Osteoarthritis/genetics , Synovial Membrane/chemistry , Translocation, Genetic/genetics , Aged , Cells, Cultured , Female , HMGA2 Protein , Humans , In Situ Hybridization, Fluorescence , Karyotyping , Male , Middle Aged
19.
Acta Orthop Scand ; 70(3): 265-7, 1999 Jun.
Article in English | MEDLINE | ID: mdl-10429602

ABSTRACT

We conducted a prospective, randomized study of 77 primary knee replacement operations on 75 patients (52 women), with a mean age of 71 years, to evaluate the effect of tourniquet release for hemostasis on blood loss and transfusion requirements. The operations were all done with spinal anesthesia and the use of a midline skin incision and medial parapatellar approach. In group I, the tourniquet was released for hemostasis before the wound was closed. In group 2, the tourniquet was first released after the wound was closed and a compressive dressing had been applied. The total intra- and postoperative blood losses were, on average, 858 mL (SD 443) in group I and 589 mL (347) in group 2 (p = 0.01). The median units of blood given and the postoperative decreases in hemoglobin values were similar in both groups. In a subgroup of 45 cementless prostheses, the 25 patients with prostheses allocated to group 1 lost 1022 mL (397) blood, compared to 646 mL (333) by the 20 patients with prostheses in group 2 (p = 0.01). Our findings speak against the efficacy of tourniquet release for hemostasis in knee replacement surgery.


Subject(s)
Arthroplasty, Replacement, Knee , Blood Loss, Surgical , Hemostasis, Surgical/adverse effects , Hemostasis, Surgical/methods , Postoperative Hemorrhage/etiology , Tourniquets/adverse effects , Adult , Aged , Aged, 80 and over , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Arthroplasty, Replacement, Knee/adverse effects , Arthroplasty, Replacement, Knee/instrumentation , Bandages , Blood Loss, Surgical/statistics & numerical data , Blood Transfusion , Female , Hemoglobins/analysis , Humans , Male , Middle Aged , Postoperative Hemorrhage/blood , Prospective Studies , Prosthesis Design
20.
J Orthop Res ; 17(3): 311-20, 1999 May.
Article in English | MEDLINE | ID: mdl-10376718

ABSTRACT

Thirty patients with gonarthrosis were operated on with the PCA primary total knee prosthesis and had the tibial component fixed to the bone by partial cementation. In the first two groups of patients, cementation was by a peripheral rim of high and low-viscosity cement, respectively. In the third group, the pegs were cemented with the low-viscosity cement. Follow-up was performed with use of clinical parameters and roentgen stereophotogrammetric analysis. Clinically, the series was successful apart from a problem with tibial component wear, necessitating revision in five patients. At 8 years, the mean Hospital for Special Surgery score was 81 points. Venn-diagram scores revealed four failures and three acceptable cases; the remaining cases were satisfactory. Apart from one loose patellar component, there was no mechanical loosening. Roentgen stereophotogrammetric analysis showed that the tibial components moved relative to the bone; this indicated fibrous tissue fixation, which was corroborated histologically in two patients. The objective, to achieve bone ingrowth, was thus not successfully met. Radiolucent lines were consistently seen, and their size correlated with the migration as measured by roentgen stereophotogrammetric analysis. Furthermore, five continuously migrating prostheses showed significantly larger radiolucent zones than the prostheses that migrated only initially, and they were less well bonded to the bone at 1 year. In conclusion, partial cementation does not appear to be a way to achieve bone ingrowth in porous-coated implants under load.


Subject(s)
Bone Cements/therapeutic use , Knee Prosthesis , Tibia/growth & development , Aged , Foreign-Body Migration/diagnostic imaging , Humans , Longitudinal Studies , Middle Aged , Photogrammetry , Prosthesis Failure , Radiography , Tibia/diagnostic imaging , Tibia/pathology , Treatment Failure
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