1.
J Labelled Comp Radiopharm
; 56(11): 587-8, 2013 Sep.
Article
in English
| MEDLINE
| ID: mdl-24285191
ABSTRACT
A breath test using [1-(13)C]glycocholic acid as a substrate is a potential diagnostic method for small intestinal bacterial overgrowth syndrome. [1-(13)C]Glycocholic acid has been thus synthesized in an excellent yield from ethyl [1-(13)C]glycinate hydrochloride in a one-pot reaction. This method is suitable for the preparation of the labeled compound on a laboratory scale, which helps to perform extensive clinical studies of the breath test.