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Bioorg Med Chem Lett
; 10(3): 277-9, 2000 Feb 07.
Article
in English
| MEDLINE
| ID: mdl-10698453
ABSTRACT
A series of 2,3-disubstituted-4-phenylquinolines were prepared and were found to inhibit the apical sodium co-dependent bile acid transporter (ASBT). Alkyl and ester substitution at the 3-position showed comparable activities while substitution at the 2-position was much more sensitive to the nature of the substituent. The synthesis and in vitro potency data are presented for this novel class of compounds.