1.
J Antibiot (Tokyo)
; 71(4): 483, 2018 03.
Article
in English
| MEDLINE
| ID: mdl-29581566
ABSTRACT
The original article can be found online at https://doi.org/10.1038/ja.2017.145 .
2.
J Antibiot (Tokyo)
; 71(2): 273-278, 2018 02.
Article
in English
| MEDLINE
| ID: mdl-29184120
ABSTRACT
Two new analogs of halistanol sulfate (1) were isolated from a marine sponge Halichondria sp. collected at Hachijo-jima Island. Structures of these new halistanol sulfates I (2) and J (3) were elucidated by spectral analyses. Compounds 1-3 showed inhibitory activity against SIRT 1-3 with IC50 ranges of 45.9-67.9, 18.9-21.1 and 21.8-37.5 µM, respectively. X-ray crystallography of the halistanol sulfate (1) and SIRT3 complex clearly indicates that 1 binds to the exosite of SIRT3 that we have discovered in this study.
