1.
Proc Soc Exp Biol Med
; 152(1): 57-60, 1976 May.
Article
in English
| MEDLINE
| ID: mdl-177992
ABSTRACT
Since age-dependent diminished macrophage function has been related to the increased susceptibility of newborn mice to herpes simplex virus (HSV) infection, the effect of several agents which might activate macrophages or other cells involved in immunity was investigated. BCG, typhoid vaccine, brucella vaccine, levamisole, or staphage lysate were administered to newborn mice prior to challenge with HSV-2. Of these agents, only BCG, administered ip or id 6 days prior to challenge, was found to increase the survival rate of newborn mice. The possible use of BCG, alone or in combination with other modalities, for the prevention or treatment of neonatal HSV infections is discussed.
Subject(s)
Animals, Newborn/immunology , Herpes Simplex/immunology , Animals , Antibodies, Viral/administration & dosage , BCG Vaccine , Herpes Simplex/prevention & control , Herpes Simplex/therapy , Immunotherapy , Macrophages/immunology , Mice , Mycobacterium bovis/immunology , Simplexvirus/immunology , Time Factors
2.
JAMA
; 229(3): 295-7, 1974 Jul 15.
Article
in English
| MEDLINE
| ID: mdl-4546093
Subject(s)
Ampicillin/pharmacology , Haemophilus influenzae/drug effects , Meningitis, Haemophilus/drug therapy , Penicillin Resistance , Age Factors , Ampicillin/administration & dosage , Ampicillin/therapeutic use , Cerebrospinal Fluid/microbiology , Child, Preschool , Cross Infection , Haemophilus influenzae/isolation & purification , Humans , Infant , Injections, Intravenous , Male , Microbial Sensitivity Tests , Otitis Media/drug therapy , Sepsis/drug therapy
3.
N C Med J
; 34(2): 109-13, 1973 Feb.
Article
in English
| MEDLINE
| ID: mdl-4510405
Subject(s)
Gonorrhea/epidemiology , Infant, Newborn, Diseases/epidemiology , Syphilis/epidemiology , Age Factors , Child , Child, Preschool , Female , Gonorrhea/diagnosis , Gonorrhea/drug therapy , Humans , Infant , Infant, Newborn , Male , North Carolina , Penicillins/therapeutic use , Syphilis/diagnosis , Syphilis/drug therapy , Syphilis Serodiagnosis , Syphilis, Congenital/diagnosis , Syphilis, Congenital/epidemiology
4.
Cleve Clin Q
; 38(2): 73-8, 1971 Apr.
Article
in English
| MEDLINE
| ID: mdl-5315599
