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Recurrent Staphylococcus aureus abscess and fatal pneumococcal septicemia due to IRAK-4 deficiency.

Shichijo, Koichi; Ogose, Takeshi; Kubota, Mari; Tomimoto, Ayumi; Kondo, Rieko; Taniguchi, Takako; Takahashi, Akiyoshi; Nakatsu, Tadanori; Urano, Yoshio; Watanabe, Tsutomu.

Pediatr Int ; 57(6): 1166-9, 2015 Dec.

Article in English | MEDLINE | ID: mdl-26711917

ABSTRACT

We describe the case of an infant with recurrent episodes of staphylococcal skin abscess and subsequent lethal pneumococcal meningitis/septicemia due to interleukin-1 receptor-associated kinase 4 (IRAK-4) deficiency. In this case, systemic signs of inflammatory response were poor and delayed. Among all other reported cases of IRAK-4 deficiency, none involved severe viral or fungal disease, and the range of infecting bacteria was narrow.

Subject(s)

Abscess/complications , Immunologic Deficiency Syndromes/complications , Meningitis, Pneumococcal/complications , Sepsis/etiology , Staphylococcal Infections/complications , Staphylococcus aureus/isolation & purification , Abscess/diagnosis , Abscess/microbiology , Fatal Outcome , Female , Follow-Up Studies , Humans , Immunologic Deficiency Syndromes/diagnosis , Infant , Interleukin-1 Receptor-Associated Kinases , Meningitis, Pneumococcal/diagnosis , Meningitis, Pneumococcal/microbiology , Primary Immunodeficiency Diseases , Sepsis/diagnosis , Sepsis/microbiology , Staphylococcal Infections/diagnosis , Staphylococcal Infections/microbiology

ABSTRACT

Subject(s)

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