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J Gastroenterol ; 38(7): 695-9, 2003.
Article in English | MEDLINE | ID: mdl-12898364

ABSTRACT

We report the case of a 25-year-old woman with fulminant hepatic failure (FHF). Liver scintigraphy using (99m)Tc-galactosyl human serum albumin (GSA) and (99m)Tc-phytate produced interesting findings; regenerative nodules appeared as nodules of increased accumulation of (99m)Tc-GSA, whereas these nodules were expressed as defects of accumulation of (99m)Tc-phytate. These scintigraphic findings suggested that the functions of hepatocytes in regenerative nodules were maintained, whereas those of Kupffer cells were impaired. Although (99m)Tc-GSA scintigraphy indicated hepatic functional reserve enough to survive, she died despite intensive therapy including plasma exchange. Based on this case, it is recommended that not only (99m)Tc-GSA scintigraphy but also (99m)Tc-phytate scintigraphy is required to evaluate the prognosis of patients with FHF.


Subject(s)
Liver Failure/diagnostic imaging , Liver Regeneration , Liver/diagnostic imaging , Adult , Female , Humans , Liver Failure/pathology , Liver Failure/physiopathology , Organotechnetium Compounds , Phytic Acid , Radionuclide Imaging , Radiopharmaceuticals , Technetium Tc 99m Aggregated Albumin , Technetium Tc 99m Pentetate
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