Polyethylene Glycols for the Dispersion Development of Graphene in an Aqueous Surfactant Solution Studied by Affinity Capillary Electrophoresis.

Water-soluble nonionic polymers of polyethylene glycol (PEG), poly(vinyl alcohol) (PVA), and polyvinylpyrrolidone (PVP) were examined to develop the dispersion of graphene in an aqueous surfactant solution. Sodium dodecylbenzenesulfonate was used as an anionic surfactant to disperse graphene in an aqueous solution and to give negative charge on it. The dispersion of graphene was monitored through the electropherograms in affinity capillary electrophoresis; a broad peak for the dispersed graphene and shot signals for the aggregated one. When PEG was added in the separation buffer as an affinity reagent, the number of the shot signals in the electropherogram was reduced; PEG can develop the dispersion of graphene in an aqueous surfactant solution. The dispersion was also developed with PVP or PVA. The effective electrophoretic mobility of the dispersed graphene was reduced by using the polymer as an affinity reagent. The result suggested that the anionic surfactant on the graphene surface was competitively substituted with the nonionic polymer. The degree of the decrease in the effective electrophoretic mobility was larger with PEG with a high-molecular mass. The broad peak of the dispersed graphene got narrower by the addition of PEG, and the number of theoretical plates was improved.

Validation of a quick three-dimensional dose verification system for pre-treatment IMRT QA.

In this study, we evaluated the dosimetric performance of the three-dimensional (3D) dose verification system, COMPASS version 3 (IBA Dosimetry, GmbH, Germany). The COMPASS has the function of a dedicated beam modeling and dose calculation. It is able to reconstruct 3D dose distributions on patient CT images, using the incident fluence from a linear accelerator measured with the MatriXX 2D array (IBA Dosimetry). The dose profiles measured with various multi-leaf collimator (MLC) test patterns for the COMPASS were checked by comparison with those of EDR2 (Eastman Kodak, Rochester, NY) films and Monte Carlo (MC) simulations. The COMPASS was also used for dose verification in clinical intensity-modulated radiation therapy (IMRT) plans for head and neck cases. The dose distributions were compared with those measured by 3DVH (Sun Nuclear, Melbourne, FL) and MC. In addition, the quality assurance (QA) times among the COMPASS, 3DVH, and EDR2 were compared. For MLC test patterns, the COMPASS dose profiles agreed within 3 % with those of EDR2 films and MC simulations. The physical resolution of the COMPASS detectors was lower than that of film, but the dose resolution for MLC patterns was comparable to that of film. In clinical plans, the dose-volume-histograms were equal for all systems. The average QA times of the COMPASS, 3DVH, and EDR2 film were 40.1, 59.4, and 121.4 min, respectively. The COMPASS system provides fast and reliable 3D dose verification for clinical IMRT QA. The COMPASS QA process does not require phantom plans. Therefore, it allows a simple QA workflow.

[Comparison of dose calculation algorithms in stereotactic radiation therapy in lung].

Dose calculation algorithms in radiation treatment planning systems (RTPSs) play a crucial role in stereotactic body radiation therapy (SBRT) in the lung with heterogeneous media. This study investigated the performance and accuracy of dose calculation for three algorithms: analytical anisotropic algorithm (AAA), pencil beam convolution (PBC) and Acuros XB (AXB) in Eclipse (Varian Medical Systems), by comparison against the Voxel Monte Carlo algorithm (VMC) in iPlan (BrainLab). The dose calculations were performed with clinical lung treatments under identical planning conditions, and the dose distributions and the dose volume histogram (DVH) were compared among algorithms. AAA underestimated the dose in the planning target volume (PTV) compared to VMC and AXB in most clinical plans. In contrast, PBC overestimated the PTV dose. AXB tended to slightly overestimate the PTV dose compared to VMC but the discrepancy was within 3%. The discrepancy in the PTV dose between VMC and AXB appears to be due to differences in physical material assignments, material voxelization methods, and an energy cut-off for electron interactions. The dose distributions in lung treatments varied significantly according to the calculation accuracy of the algorithms. VMC and AXB are better algorithms than AAA for SBRT.

[Dose impact of a carbon fiber couch for stereotactic body radiation therapy of lung tumors].

The aim of this study was to measure the dose attenuation caused by a carbon fiber radiation therapy table (Imaging Couch Top; ICT, BrainLab) and to evaluate the dosimetric impact of ICT during stereotactic body radiation therapy (SBRT) in lung tumors. The dose attenuation of ICT was measured using an ionization chamber and modeled by means of a treatment planning system (TPS). SBRT was planned with and without ICT in a lung tumor phantom and ten cases of clinical lung tumors. The results were analyzed from isocenter doses and a dose-volume histogram (DVH): D95, Dmean, V20, V5, homogeneity index (HI), and conformity index (CI). The dose attenuation of the ICT modeled with TPS agreed to within ±1% of the actually measured values. The isocenter doses, D95 and Dmean with and without ICT showed differences of 4.1-5% for posterior single field and three fields in the phantom study, and differences of 0.6-2.4% for five fields and rotation in the phantom study and six fields in ten clinical cases. The dose impact of ICT was not significant for five or more fields in SBRT. It is thus possible to reduce the dose effect of ICT by modifying the beam angle and beam weight in the treatment plan.