Morphology of urothelial papillary tumors.

A total of one hundred forty-seven urothelial papillary tumors (UPT) from 14 cystectomy specimens were studied, matching the morphology of these tumors as seen with a dissecting microscope with the histology. Two kinds of papillae (digitate and laminar) were identified as the elementary structures of the UPT. According to their composition, urinary papillary tumors have been classified as: digitate (mainly digitate papillae), laminar (mainly laminar papillae), laminodigitate (tumors in which neither digitate nor laminar papillae clearly prevail).

Neoplastic invasion of the connective stalks in transitional cell papillary tumors (TCPT) of the bladder.

Neoplastic invasion into the connective stalks of transitional cell papillary tumors of the bladder was assessed in TUR specimens from new cases. There were 21 G1 cases, none of which showed invasion of the connective tissue stalk; this compared with definite invasion in 19 of 77 G2 cases (25%) and in 16 of 17 G3 cases (94%). During a 5 year follow-up period more of the stalk invasive cases had an unfavorable course (fatal outcome or total cystectomy) than of the stalk non-invasive cases; this was statistically significant (p less than 0.01) for the whole group of patients and for the smaller group of patients with G2 tumors (p less than 0.05).

Cytologic diagnosis of prostatic malakoplakia. Report of three cases.

Three cases of prostatic malakoplakia are reported. The cytologic findings in the smears obtained by transrectal fine needle aspiration biopsy are compared with the histologic findings obtained by simultaneously performed transrectal punch biopsy. The striking cytologic finding was the presence of large isolated histiocytes with abundant foamy cytoplasm. The concentrically laminated Michaelis-Gutmann bodies that are characteristic of malakoplakia were seen both within the histiocytes and, occasionally, in the extracellular background. The smears were further characterized by a granulomatous inflammatory reaction, consisting of large numbers of polymorphonuclear leukocytes, lymphocytes and plasma cells. These findings appear to be sufficient to make a diagnosis of this rare lesion in a prostatic aspirate. To our knowledge, this is the first description of the cytology of prostatic malakoplakia.

Growth and modeling of urothelial papillary tumors.

The development of urothelial papillary tumors (UPT) has been interpreted from some histologic patterns to suggest that intraurothelial vascularization and opening of urothelial nests that have grown in the lamina propria are basic processes for the development, growth, and modeling of UPT. These basic processes can combine in different ways to form the complex structures that compose UPT.

Anaerobic and aerobic bacteria in secretions of prostate and seminal vesicles of infertile men.

A cytological and bacteriological study was made of prostatic (EPS) and vesicular (EVS) secretions from 123 infertile men who were suspected of having chronic genital tract inflammation and from 31 men with premature ejaculation (1,12,16). In the microbiological investigations samples were inoculated within 10 min on various culture media and incubated under both aerobic and anaerobic conditions. Bacterial loads of more than 10,000 colony-forming units of a single species or genus per milliliter of EPS or EVS were considered to be pathological. In the infertile subjects with proven inflammation of the seminal accessory glands, the EPS and the EVS that gave positive cultures and had bacterial loads defined as pathological contained large numbers of anaerobic or microaerophilic organisms (EPS: 51 of the 63 bacterial strains found, congruent to 81%; EVS: 19 of the 20 bacterial strains found, congruent to 95%).

High-resolution protein patterns of human expressed prostatic secretion: a new tool for the diagnosis of prostatitis.

Expressed prostatic secretions (EPS) obtained from 62 infertile and urological patients have been analyzed for their protein content by sodium dodecylsulfate electrophoresis and isoelectrofocusing. Independent cytological and bacteriological screening on the same EPS samples was carried out to detect prostatic inflammation. EPS from both urological and infertile patients without inflammation had simple and characteristic protein patterns. Important qualitative and quantitative differences in the protein composition of EPS from patients with severe dysspermia or prostatic inflammation were found. The comparison of EPS protein patterns with those of seminal plasma obtained from the same patients led to the detection of a characteristic group of low-molecular-weight bands that were not of prostatic origin.