High dose rates obtained outside ISS in June 2015 during SEP event.

The R3DR2 instrument performed measurements in the European Space Agency (ESA) EXPOSE-R2 platform outside the Russian "Zvezda" module of the International Space Station (ISS) in the period 24 October 2014-11 January 2016. It is the Liulin-type deposited energy spectrometer (DES) (Dachev et al., 2015a). Took place in November 2014, this was the first attempt to monitor a small solar energetic particle (SEP) event outside ISS using the Liulin-type DES (Dachev et al., 2015d). In this study, we describe the dosimetric characteristics of the largest SEP event, observed on 22 June 2015 with the R3DR2 instrument outside ISS. The main finding of this study is that SEP protons with a minimum energy of approximately 7MeV at the surface of the R3DR2 detector produced high dose rates, reaching >5000µGyh(-1), while the inner radiation belt maximum dose was at the level of 2200µGyh(-1). If a virtual external vehicle activity (EVA) was performed in the same period of the SEP maximum on 22 June 2015, the doses obtained in the skin of cosmonauts/astronauts can reach 2.84mGy after 6.5h, which is similar to the average absorbed dose inside ISS for 15days (Reitz et al., 2005). A comparison with other extreme events measured with Liulin-type instruments shows that SEPs similar to that observed on 22 June 2015 could be one of the most dangerous events for the cosmonauts/astronauts involved in EVA.

Overview of the Liulin type instruments for space radiation measurement and their scientific results.

Ionizing radiation is recognized to be one of the main health concerns for humans in the space radiation environment. Estimation of space radiation effects on health requires the accurate knowledge of the accumulated absorbed dose, which depends on the global space radiation distribution, solar cycle and local shielding generated by the 3D mass distribution of the space vehicle. This paper presents an overview of the spectrometer-dosimeters of the Liulin type, which were developed in the late 1980s and have been in use since then. Two major measurement systems have been developed by our team. The first one is based on one silicon detector and is known as a Liulin-type deposited energy spectrometer (DES) (Dachev et al., 2002, 2003), while the second one is a dosimetric telescope (DT) with two or three silicon detectors. The Liulin-type instruments were calibrated using a number of radioactive sources and particle accelerators. The main results of the calibrations are presented in the paper. In the last section of the paper some of the most significant scientific results obtained in space and on aircraft, balloon and rocket flights since 1989 are presented.

Liulin-type spectrometry-dosimetry instruments.

The main purpose of Liulin-type spectrometry-dosimetry instruments (LSDIs) is cosmic radiation monitoring at the workplaces. An LSDI functionally is a low mass, low power consumption or battery-operated dosemeter. LSDIs were calibrated in a wide range of radiation fields, including radiation sources, proton and heavy-ion accelerators and CERN-EC high-energy reference field. Since 2000, LSDIs have been used in the scientific programmes of four manned space flights on the American Laboratory and ESA Columbus modules and on the Russian segment of the International Space Station, one Moon spacecraft and three spacecraft around the Earth, one rocket, two balloons and many aircraft flights. In addition to relative low price, LSDIs have proved their ability to qualify the radiation field on the ground and on the above-mentioned carriers.

Locoregional IL-2 low dose applications for gastrointestinal tumors.

AIM: To explore the feasibility of local interleukin 2 (IL-2) in patients with different forms of abdominal cancer. This required experimentation with the time interval between IL-2 applications and the methods of application. METHODS: Sixteen patients with stages III and IV of gastrointestinal malignancies (primary or metastatic) who were admitted to our Department of Gastroenterology were treated with locoregionally applied IL-2 in low doses. RESULTS: No major problems applying locoregional IL-2 were encountered. In 6 out of 16 patients, a modest but clinically worthwhile improvement was obtained. Adverse effects were minimal. The therapeutic scheme was well tolerated, even in patients in a poor condition. CONCLUSION: This study demonstrates the feasibility of low dose locoregional IL-2 application in advanced abdominal cancer. Local IL-2 therapy gives only negligible adverse effects. The results suggest that it is important to apply intratumorally. Local IL-2 may be given adjunct to standard therapeutic regimes and does not imply complex surgical interventions. These initial results are encouraging.

Non-melanoma and non-renal cell carcinoma malignancies treated with interleukin-2.

Some positive results have been observed after interleukin-2 treatment, especially in melanoma, and pulmonary metastasis of renal carcinoma. The aim of the following article is to analyze the response to interleukin-2 in patients with non-melanoma and non-renal cells malignancies. The response was studied with reference to the interleukin-2 dose, the way of application, the kind of tumor and the other treatments. A database search was performed to trace studies describing interleukin-2 tumor treatment in non-melanoma and non-renal cells malignancies, published between 1.1.1999 and 30.01.2001. We found 38 communications for the use of interleukin-2 in a total of 1030 patients. The literature review suggests that the optimal way of application of interleukin-2 in metastatic colorectal carcinoma is the local use in a low dose, with intervals between applications, for 4-6 months, after some pretreatment. In unresectable pancreatic head carcinoma a total response was 85% with twice prolonged survival. In malignant mesothelioma--stable disease was achieved in 56% with potential advantages of local application. In hematological malignancies interleukin-2 treatment was followed by remission or increase in immune defense depending on the histological type. In breast cancer interleukin-2 induced immunologically functional graft. Metastatic pulmonary carcinoma has a favorable prognosis concerning response and survival. The maintenance treatment with low doses of interleukin-2 in responders to previous chemotherapy is promising. Better results are observed with lower dose, cyclic application and combining chemotherapy. Cycles with longer duration (4-6 months) have a better effect also for patients with response to former treatment.

Analysis of the Cyclotron Facility calibration and aircraft dosimetry results from the LIULIN-3M instrument.

The LIULIN-3M instrument is a further development of the LIULIN dosimeter-radiometer, used on the MIR spacestation during the 1988-1994 time period. The LIULIN-3M is designed for continuous monitoring of the radiation environment during the BION-12 satellite flight in 1999. A semiconductor detector with 1 mm thickness and cm2 area is contained in the instrument. Pulse high analysis technique is used to determine the energy losses in the detector. The final data from the instrument are the flux and the dose rate for the exposure time and 256 channels of absorbed dose spectra based on the assumption that the particle flux is normal to the detector. The LIULIN-3M instrument was calibrated by proton fluxes with different energies at the Indiana University Cyclotron Facility in June 1997 and had been used for radiation measurements during commercial aircraft flights. The calibration procedure and some flight results are presented in this paper.

Calibration results obtained with Liulin-4 type dosimeters.

The Mobile Radiation Exposure Control System's (Liulin-4 type) main purpose is to monitor simultaneously the doses and fluxes at 4 independent places. It can also be used for personnel dosimetry. The system consists of 4 battery-operated 256-channel dosimeters-spectrometers. We describe results obtained during the calibrations of the spectrometers at the Cyclotron facilities of the University of Louvain, Belgium and of the National Institute of Radiological Sciences-STA, Chiba, Japan with protons of energies up to 70 MeV. The angular sensitivities of the devices are studied and compared with Monte-Carlo predictions. We also present the results obtained at the HIMAC accelerator with 500 MeV/u Fe ions and at the CERN high energy radiation reference fields. Records made during airplane flights are shown and compared with the predictions of the CARI-6 model.

Solar cycle variations of MIR radiation environment as observed by the LIULIN dosimeter.

Measurements on board the MIR space station by the Bulgarian-Russian dosimeter LIULIN have been used to study the solar cycle variations of the radiation environment. The fixed locations of the instrument in the MIR manned compartment behind 6-15 g/cm2 of shielding have given homogeneous series of particle fluxes and doses measurements to be collected during the declining phase of 22nd solar cycle between September 1989 and April 1994. During the declining phase of 22nd solar cycle the GCR (Galactic Cosmic Rays) flux observed at L>4 (where L is the McIlwain parameter) has enhanced from 0.6-0.7 cm-2 s-1 up to 1.4-1.6 cm-2 s-1. The long-term observations of the trapped radiation can be summarized as follows: the main maximum of the flux and dose rate is located at the southeast side of the geomagnetic field minimum of South Atlantic Anomaly (SAA) at L=1.3-1.4. Protons depositing few (nGy cm2)/particle in the detector predominantly populate this region. At practically the same spatial location and for similar conditions the dose rate rises up from 480 to 1470 microGy/h dose in silicon in the 1990-1994 time interval, during the declining phase of the solar cycle. On the other hand the flux rises from 35 up to 115 cm-2 s-1 for the same period of time. A power law dependence was extracted which predicts that when the total neutral density at the altitude of the station decreases from 8x10(-15) to 6x10(-16) g/cm3 the dose increase from about 200 microGy/h up to 1200 microGy/h. At the same time the flux increase from about 30 cm-2 s-1 up to 120 cm-2 s-1. The AP8 model predictions give only 5.8% increase of the flux for the same conditions.

Inner magnetosphere variations after solar proton events. Observations on Mir space station in 1989-1994 time period.

Measurements on board the Mir space station have been used to study the dose rate and the particle flux distribution in the inner magnetosphere. The measurements have been performed with the Bulgarian-Russian dosimeter-radiometer Liulin. The paper concentrates on the dynamics of the observed "new" and "second" maxima which were created after Solar Proton Events (SPE) in the 1989-1994 time. The "second" belt was first observed after the SPE on October 20, 1989, and the last observation was after the SPE on February 20, 1994. The creation of the "new" belt is a unique phenomena seen in the Liulin data set after the SPE on March 23, 1991 and relates to the magnetic storm on March 24. The new belt fully disappears in the middle of 1993.

New results for the space radiation environment of MIR space station obtained by Liulin dosimeter-radiometer. Comparison with LET spectrometer NAUSICAA.

Since 1988 high sensitivity semiconductor dosimeter-radiometer "Liulin" worked on board of MIR space station. Device measured the absorbed dose rate and the flux of penetrating particles. The analysis of the data shows the following new results: In October 1989 and after March 24, 1991, two additional stable maximums in flux channel were observed in the southern-eastern part of South Atlantic Anomaly (SAA). These two maximums existed at least several months and seem to be due to trapped high energy electron and proton fluxes. In April 1991 additional maximums were localized in the following geographical coordinates regions: latitude = (-35 degrees)-(-50 degrees) longitude = 332 degrees-l6 degrees and lat.(-46 degrees)-(-52 degrees) long. 360 degrees-60 degrees. Additional maximums diffusion occurs inside radiation belt. Appearance of these maximums seems to be closely connected with preceding powerful solar proton events and associated geomagnetic dynamics of new belt disturbances. Alter the series of solar proton events in June 1991 we observed significant enhancement of this new radiation belt formation. To achieve sufficient accuracy of dose rate predictions in low Earth orbits the structure and dynamics of new belt should be carefully analyzed to be included in a new environment model. From the inter comparison of the data from "Liulin" and French developed tissue equivalent LET spectrometer NAUSICAA in the time period August-November 1992 we come to the following conclusions: Mainly there is good agreement between both data sets for absorbed dose in the region of SAA; Different situation of the instruments on the station can explain the cases when differences up to 2 times are observed; At high latitudes usually the tissue equivalent absorbed dose observations are 2 times larger than "Liulin" doses.

Proposal for a new radiation dose control system for future manned space flights.

Radiation risk on a future long-duration manned space mission appears to be one of the basic factors in planning and designing the mission. Since 1988 different active dosimetric investigations has been performed on board the MIR space station by the Bulgarian-Russian dosimeter-radiometer LIULIN and French tissue-equivalent proportional counters CIRCE and NAUSICAA. A joint French-Bulgarian-Russian dosimetry experiment and the dosimetry-radiometry system RADIUS-MD have been developed for the future MARS-96 mission. On the base of the results and experience of these investigations a conception for a new radiation dose control system for the future orbital stations, lunar bases and interplanetary space ships is proposed. The proposed system which consists of different instruments will allow personal radiation control for crew members, radiation monitoring inside and outside each habitat, analysis and forecasting of the situation and will suggest procedures to minimize the radiation risk.

Dosimetric investigations on Mars-96 mission.

The dosimetric experiments Dose-M and Liulin as part of the more complex French-German-Bulgarian-Russian experiments for the investigation of the radiation environment for Mars-96 mission are described. The experiments will be realized with dosemeter-radiometer instruments, measuring absorbed dose in semiconductor detectors and the particle flux. Two detectors will be mounted on board the Mars-96 orbiter. Another detector will be on the guiderope of the Mars-96 Aerostate station. The scientific aims of Dose-M and Liulin experiments are: Analysis of the absorbed dose and the flux on the path and around Mars behind different shielding. Study of the shielding characteristics of the Martian atmosphere from galactic and solar cosmic rays including solar proton events. Together with the French gamma-spectrometer and the German neutron detectors the investigation of the radiation environment on the surface of Mars and in the atmosphere up to 4000 m altitude will be conducted.

"Mir" radiation dosimetry results during the solar proton events in September-October 1989.

Using data from dosimetry-radiometry system "Liulin" on board of "Mir"-space station the particle flux and doserate during September-October, 1989 has been studied. The orbit of the station was 379 km perigee, 410 km apogee and 51.6 degrees inclination. Special attention has been paid to the flux and doserate changes inside the station after intensive solar proton events (SPE) on 29 of September, 1989. The comparison between the doses before and after the solar flares shows increase of the calculated mean dose per day by factor of 10 to 200. During the SPE on the 29 of September the additional dose was 310 mrad. The results of the experiment are compared with the data for the solar proton fluxes obtained on the GOES-7 satellite.