ABSTRACT
Chronic viral hepatitis C is associated with decreased production of TNF-alpha by the peripheral blood mononuclear leukocytes irrespective of virus genotype and degree of the morphological activity of the process in the liver. This process positively correlates with the increase in the content of TNF-alpha soluble receptor (molecular weight 55 kDa), which can play a role in the mechanisms of immunopathogenesis of long persistence of hepatitis C virus in the body.
Subject(s)
Hepatitis C, Chronic/immunology , Leukocytes, Mononuclear/metabolism , Tumor Necrosis Factor-alpha/biosynthesis , Adolescent , Adult , Down-Regulation , Female , Hepacivirus/genetics , Humans , Liver/pathology , Liver/virology , Male , Middle AgedABSTRACT
Study of the proliferative potential and immunophenotype of lymphocytes and cytokine-producing capacity of mononuclear cells in patients with chronic tick-borne encephalitis virus antigenemia showed changes in T cell lymphoproliferative response, relative content of T cells and T helper inductors, immunoregulatory index, and imbalance in the production of immunoregulatory Th1 and Th2 cytokines.
