1.
Chem Pharm Bull (Tokyo)
; 57(3): 288-93, 2009 Mar.
Article
in English
| MEDLINE
| ID: mdl-19252322
ABSTRACT
Novel conformationally restricted diamine derivatives containing imidazolidinylidene propanedinitrile were synthesized and evaluated for human and rat histamine H(3) receptor (H(3)R) binding affinities. Among them, compounds 2b, 2c, 2j, 2k and 2m were found to be potent ligands for both H(3)Rs with K(i) values in the sub-nanomolar range, and showed potent H(3) receptor antagonism.