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1.
J Neonatal Perinatal Med ; 16(4): 747-754, 2023.
Article in English | MEDLINE | ID: mdl-38007678

ABSTRACT

Lymphatic malformations are rare benign developmental anomalies of the lymphatic system that can be diagnosed by prenatal ultrasound. Depending on their anatomical site and size, the lesions can cause a variety of aesthetic and functional deficits. Several treatment options are available, the most suitable is still under debate. The experience gained at our Centre and the review of the literature can be useful to improve prenatal counseling, that is challenging due to the heterogeneity of clinical presentation and treatment.


Subject(s)
Lymphatic Abnormalities , Ultrasonography, Prenatal , Female , Humans , Pregnancy , Lymphatic Abnormalities/diagnostic imaging , Lymphatic Abnormalities/therapy , Prenatal Diagnosis , Fetal Diseases/diagnostic imaging , Fetal Diseases/therapy
2.
J Pediatr Urol ; 13(2): 199.e1-199.e5, 2017 Apr.
Article in English | MEDLINE | ID: mdl-28254239

ABSTRACT

INTRODUCTION: Bladder-exstrophy-epispadias complex (BEEC) represents a spectrum of urogenital step-wise malformations: epispadias, complete exstrophy, and cloacal exstrophy. Psychosexual development in adolescent patients with BEEC may become especially problematic. At present, there are few contributions in the literature investigating the validity of psychosexual treatment in order to tackle this particularly emotional and personal development phase. OBJECTIVE: The study aimed at verifying the efficacy of an intervention methodology for psychosexual support of a group of adolescents with BEEC. The main goal of the intervention program was to educate the adolescents and re-frame how they see themselves or feel about themselves, especially in relation to BEEC. In particular it was predicted that the program could: (1) improve the perception of pleasure concerning the body, particularly regarding the genital area, giving proper and specific information on pleasure, masturbation and medical history of BEEC; and (2) elicit a more relational-affective perspective on sexuality. STUDY DESIGN: 13 adolescent patients took part in the 1-year program. The effects of the intervention program were verified through a test-retest methodology using Sexuality Evaluation Schedule Assessment Monitoring (SESAMO). RESULTS: The results showed that participants changed their attitude in several psychosexual areas, more specifically: psycho-environmental situations, body experience, areas of pleasure, medical and sexual history, and motivation and conflict areas (Summary Table). DISCUSSION: This study demonstrated, for the first time, that a targeted program may significantly improve the psycho-sexual condition of adolescents with BEEC. In particular, this research showed that adolescents need to be able to discuss and tackle topics of a psychological and sexual nature, as well as receive understandable answers that can be put into practice in their everyday lives. The study had several methodological limitations, especially owing to the limited number of participants, the absence of a follow-up period of a few months after the intervention, and the overall exploratory nature of the program. CONCLUSION: This intervention methodology may be considered a first attempt at improving the self-esteem of adolescents with BEEC, by contrasting forms of psychological difficulties in order to improve the quality of life of these young people.


Subject(s)
Bladder Exstrophy/psychology , Epispadias/psychology , Psychosexual Development/physiology , Sexual Behavior/psychology , Surveys and Questionnaires , Adolescent , Bladder Exstrophy/diagnosis , Bladder Exstrophy/surgery , Body Image , Cohort Studies , Epispadias/diagnosis , Epispadias/surgery , Female , Follow-Up Studies , Humans , Italy , Male , Pilot Projects , Quality of Life , Retrospective Studies , Risk Assessment , Self Concept , Urogenital Abnormalities/diagnosis , Urogenital Abnormalities/psychology , Urogenital Abnormalities/surgery , Urogenital Surgical Procedures/methods
3.
Ann Oncol ; 13(6): 956-64, 2002 Jun.
Article in English | MEDLINE | ID: mdl-12123342

ABSTRACT

BACKGROUND: We previously reported that stage 3 neuroblastoma comprises (i) a low-risk group including all infants (age 0-11 months) as well as older children with non-abdominal primaries, and (ii) a high-risk group made up of children >1 year of age with abdominal primaries. Aggressive chemotherapy was effective only in the latter group. PATIENTS AND TREATMENT: On this basis, in 1990 we designed a new protocol by which all low-risk patients received standard-dose chemotherapy, while the high-risk ones received very aggressive chemotherapy. RESULTS: Between November 1990 and December 1997 a total of 95 eligible and evaluable children were enrolled: 47 were low-risk (35 infants and 12>1 year of age at diagnosis and having non-abdominal primaries), and 48 were high-risk (being >1 year of age and having abdominal primaries). Of the 47 low-risk patients, five relapsed and four subsequently died. The 5-year overall survival (OS) was 91%. Of the 48 patients in the high-risk group, 22 relapsed or progressed, 18 of whom died from their disease and two from toxicity, and one was lost to follow-up. The 5-year OS was 60%. Univariate analysis showed that age, site of primary, risk-group, urine vanillylmandelic excretion, plasma levels of lactate dehydrogenase, ferritin and neurone-specific enolase, and MYCN status correlated with outcome. However, multivariate analysis showed that only MYCN status retained prognostic value. CONCLUSIONS: In low-risk stage 3 neuroblastoma, standard-dose chemotherapy is associated with an excellent chance of being cured. Aggressive chemotherapy is effective for high-risk patients, but results are still unsatisfactory. MYCN gene amplification is a prognostic indicator for most, but not all, treatment failures.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Neuroblastoma/drug therapy , Neuroblastoma/mortality , Biopsy, Needle , Child , Child, Preschool , Cyclophosphamide/administration & dosage , Dose-Response Relationship, Drug , Doxorubicin/administration & dosage , Drug Administration Schedule , Female , Humans , Infant , Infant, Newborn , Male , Neoadjuvant Therapy , Neoplasm Staging , Neuroblastoma/pathology , Neuroblastoma/surgery , Prognosis , Proportional Hazards Models , Retrospective Studies , Risk Assessment , Survival Analysis , Treatment Outcome , Vincristine/administration & dosage
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