[Prediction of seizures in sleep based on power spectrum].

Seizures during sleep increase the probability of complication and sudden death. Effective prediction of seizures in sleep allows doctors and patients to take timely treatments to reduce the aforementioned probability. Most of the existing methods make use of electroencephalogram (EEG) to predict seizures, which are not specific developed for the sleep. However, EEG during sleep has its characteristics compared with EEG during other states. Therefore, in order to improve the sensitivity and reduce the false alarm rate, this paper utilized the characteristics of EEG to predict seizures during sleep. We firstly constructed the feature vector including the absolute power spectrum, the relative power spectrum and the power spectrum ratio in different frequencies. Secondly, the separation criterion and branch-and-bound method were applied to select features. Finally, support vector machine classifier were trained, which is then employed for online prediction. Compared with the existing method that do not consider the characteristics of sleeping EEG (sensitivity 91.67%, false alarm rate 9.19%), the proposed method was superior in terms of sensitivity (100%) and false alarm rate (2.11%). This method can improve the existing epilepsy prediction methods and has important clinical value.

Accurate and Robust Non-rigid Point Set Registration using Student's-t Mixture Model with Prior Probability Modeling.

A new accurate and robust non-rigid point set registration method, named DSMM, is proposed for non-rigid point set registration in the presence of significant amounts of missing correspondences and outliers. The key idea of this algorithm is to consider the relationship between the point sets as random variables and model the prior probabilities via Dirichlet distribution. We assign the various prior probabilities of each point to its correspondences in the Student's-t mixture model. We later incorporate the local spatial representation of the point sets by representing the posterior probabilities in a linear smoothing filter and get closed-form mixture proportions, leading to a computationally efficient registration algorithm comparing to other Student's-t mixture model based methods. Finally, by introducing the hidden random variables in the Bayesian framework, we propose a general mixture model family for generalizing the mixture-model-based point set registration, where the existing methods can be considered as members of the proposed family. We evaluate DSMM and other state-of-the-art finite mixture models based point set registration algorithms on both artificial point set and various 2D and 3D point sets, where DSMM demonstrates its statistical accuracy and robustness, outperforming the competing algorithms.

Combining SENSE and reduced field-of-view for high-resolution diffusion weighted magnetic resonance imaging.

BACKGROUND: In diffusion-weighted magnetic resonance imaging (DWI) using single-shot echo planar imaging (ss-EPI), both reduced field-of-view (FOV) excitation and sensitivity encoding (SENSE) alone can increase in-plane resolution to some degree. However, when the two techniques are combined to further increase resolution without pronounced geometric distortion, the resulted images are often corrupted by high level of noise and artifact due to the numerical restriction in SENSE. Hence, this study is aimed to provide a reconstruction method to deal with this problem. METHODS: The proposed reconstruction method was developed and implemented to deal with the high level of noise and artifact in the combination of reduced FOV imaging and traditional SENSE, in which all the imaging data were considered jointly by incorporating the motion induced phase variations among excitations. The in vivo human spine diffusion images from ten subjects were acquired at 1.5 T and reconstructed using the proposed method, and compared with SENSE magnitude average results for a range of reduction factors in reduced FOV. These images were evaluated by two radiologists using visual scores (considering distortion, noise and artifact levels) from 1 to 10. RESULTS: The proposed method was able to reconstruct images with greatly reduced noise and artifact compared to SENSE magnitude average. The mean g-factors were maintained close to 1 along with enhanced signal-to-noise ratio efficiency. The image quality scores of the proposed method were significantly higher (P < 0.01) than SENSE magnitude average for all the evaluated reduction factors. CONCLUSION: The proposed method can improve the combination of SENSE and reduced FOV for high-resolution ss-EPI DWI with reduced noise and artifact.

A multilevel-ROI-features-based machine learning method for detection of morphometric biomarkers in Parkinson's disease.

Machine learning methods have been widely used in recent years for detection of neuroimaging biomarkers in regions of interest (ROIs) and assisting diagnosis of neurodegenerative diseases. The innovation of this study is to use multilevel-ROI-features-based machine learning method to detect sensitive morphometric biomarkers in Parkinson's disease (PD). Specifically, the low-level ROI features (gray matter volume, cortical thickness, etc.) and high-level correlative features (connectivity between ROIs) are integrated to construct the multilevel ROI features. Filter- and wrapper- based feature selection method and multi-kernel support vector machine (SVM) are used in the classification algorithm. T1-weighted brain magnetic resonance (MR) images of 69 PD patients and 103 normal controls from the Parkinson's Progression Markers Initiative (PPMI) dataset are included in the study. The machine learning method performs well in classification between PD patients and normal controls with an accuracy of 85.78%, a specificity of 87.79%, and a sensitivity of 87.64%. The most sensitive biomarkers between PD patients and normal controls are mainly distributed in frontal lobe, parental lobe, limbic lobe, temporal lobe, and central region. The classification performance of our method with multilevel ROI features is significantly improved comparing with other classification methods using single-level features. The proposed method shows promising identification ability for detecting morphometric biomarkers in PD, thus confirming the potentiality of our method in assisting diagnosis of the disease.

Examining population differences in cerebral morphometry between Chinese and Indian undergraduate students.

The aim of this study is to examine potential population differences in brain morphometry using magnetic resonance imaging (MRI). Thirty-six Chinese and thirty-two Indian undergraduate students are included in this study. All images are processed using BrainLab toolbox to obtain the morphometric values of gray matter volume, cortical thickness, and cortical surface area in each region of interest (ROI). We use ROI-based analysis to investigate ethnic differences using the three types of measurements. Cerebral variations of the brain between Chinese and Indian groups are mostly distributed in the frontal lobe, temporal lobe, and occipital lobe. Subgroup analysis reveals sex differences between the two groups. Our study demonstrates population-related differences in brain morphometry (gray matter volume, cortical thickness, and cortical surface area) between Chinese and Indian undergraduates.