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World J Gastroenterol ; 11(9): 1292-6, 2005 Mar 07.
Article in English | MEDLINE | ID: mdl-15761966

ABSTRACT

AIM: To investigate the possible association between hepatitis B virus (HBV) infection and angiographically proven coronary artery disease (CAD) in a population with relatively high prevalence of HBV. METHODS: Sera from 434 patients who underwent coronary angiography were tested for HBV antigens (HBsAg, HBeAg) and antibodies (Anti-HBs, Anti-HBc and Anti-HBe) by ELISA. RESULTS: Seventy-seven percent (224/291) of the patients with CAD and 73.4% (105/143) of the patients without angiographic evidence of atherosclerosis were seropositive for HBV (P > 0.05). However, C-reactive protein (CRP) levels were significantly higher in patients with CAD (P = 0.008), while lower in HBV seropositive population (P = 0.043 and P = 0.021 after adjustment for conventional risk factors). CONCLUSION: Our results suggested HBV infection negatively correlates with CRP levels, but seems not to be associated with coronary atherosclerosis.


Subject(s)
Coronary Artery Disease/epidemiology , Hepatitis B, Chronic/epidemiology , Aged , C-Reactive Protein/metabolism , China/epidemiology , Female , Hepatitis B Antibodies/blood , Hepatitis B Surface Antigens/immunology , Hepatitis B e Antigens/immunology , Hepatitis B, Chronic/immunology , Humans , Male , Middle Aged , Risk Factors , Seroepidemiologic Studies
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