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Bioorg Med Chem Lett ; 23(10): 3001-6, 2013 May 15.
Article in English | MEDLINE | ID: mdl-23566518

ABSTRACT

Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biological activity and mode-of-action for a class of 4-heterocyclic aryl isoxazoline insecticides.


Subject(s)
Chloride Channels/antagonists & inhibitors , Insecticides/pharmacology , Isoxazoles/pharmacology , Receptors, GABA/metabolism , Animals , Chloride Channels/metabolism , Dose-Response Relationship, Drug , Insecta , Insecticides/chemical synthesis , Insecticides/chemistry , Isoxazoles/chemical synthesis , Isoxazoles/chemistry , Molecular Structure , Structure-Activity Relationship
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