ABSTRACT
This article studies the clinical features of the flow of the gastrointestinal tract and liver in the formation of osteopenia and osteoporosis. Were shown the incidence of disorders of bone mineral density in patients with chronic pancreatitis, liver cirrhosis, gallstone disease, inflammatory bowel diseases, and diseases accompanied by syndrome of malabsorption (gluten enteropathy, a syndrome of short small intestine). Were established population (age, sex, lower body mass index, menopause), clinical and laboratory factors indicating high risk of lower bone mineral density in these patients.
Subject(s)
Bone Density , Bone Diseases, Metabolic/metabolism , Digestive System Diseases/metabolism , Absorptiometry, Photon , Bone Diseases, Metabolic/diagnostic imaging , Bone Diseases, Metabolic/etiology , Digestive System Diseases/complications , Digestive System Diseases/diagnosis , Female , Humans , Male , Menopause , Middle Aged , Sex FactorsABSTRACT
Paper is devoted to the study of the clinical features of the course diseases of gastrointestinal tract and liver in the formation of osteopenia and osteoporosis. Given frequencies of occurrence of infringements of mineral density of bone at patients with chronic pancreatitis, cirrhosis, cholelithiasis, inflammatory bowel disease as well as diseases that are accompanied by malabsorption syndromes (celiac enteropathy syndrome of short small intestine). Established populational (age, sex, lower body mass index, menopause), clinical and laboratory factors indicating high risk of lower bone mineral density in these patients.
Subject(s)
Bone Density , Digestive System Diseases/metabolism , Digestive System Diseases/pathology , Osteoporosis/metabolism , Osteoporosis/pathology , Adult , Chronic Disease , Digestive System Diseases/complications , Digestive System Diseases/physiopathology , Female , Humans , Male , Middle Aged , Osteoporosis/etiology , Osteoporosis/physiopathologySubject(s)
Amyloidosis/diagnosis , Liver Failure/diagnosis , Polycythemia/complications , Renal Insufficiency/diagnosis , Amyloidosis/complications , Amyloidosis/therapy , Disease Progression , Fatal Outcome , Humans , Liver Failure/complications , Male , Middle Aged , Renal Insufficiency/complicationsABSTRACT
The article presents research data of BMD in 106 patients with liver cirrhosis. The core group of examined patients presented with LC patients the etiology of alcohol--37.7% and primary biliary cirrhosis--35.8%. In 68.9% of patients with established deficits of bone mineral density, by 24.6%--at the level of osteoporosis. Was detected influence of the etiology of the disease on the frequency of osteopenia and osteoporosis containment. Was made analysis of dependence of the frequency of osteopenia, and/or osteoporosis of population risk factors, duration of disease, grade of liver failure on the Child-Pugh. A comparative assessment of the effectiveness treatment of disorders of BMD active metabolite of vitamin D3--alpha caltsidol and drugs from the group of bisphosphonates.
Subject(s)
Bone Demineralization, Pathologic/etiology , Liver Cirrhosis/complications , Absorptiometry, Photon , Bone Demineralization, Pathologic/diagnostic imaging , Bone Demineralization, Pathologic/epidemiology , Bone Demineralization, Pathologic/prevention & control , Bone Density Conservation Agents/administration & dosage , Bone Density Conservation Agents/therapeutic use , Calcifediol/administration & dosage , Calcifediol/therapeutic use , Diphosphonates/administration & dosage , Diphosphonates/therapeutic use , Female , Humans , Liver Cirrhosis/epidemiology , Liver Cirrhosis, Alcoholic/complications , Male , Middle AgedABSTRACT
The article represents BMD (bone mineral density) study of 75 patients with a cirrhosis of liver. Main group of patients under study was represented by alcoholic cirrhosis patients - 45%, and primary biliary cirrhosis - 36%. 72% of patients were established BMD deficit, 25% on osteoporosis level. Influence of disease etiology on osteopenia frequency and/or osteoporosis localization was diagnosed. Dependence of osteopenia frequency and/or osteoporosis from population risk factors, duration of disease, hepatic insufficiency class under Child-Pugh score was analyzed.
