Subject(s)
Biomarkers/blood , Hepatitis B, Chronic/complications , Hepatitis B, Chronic/immunology , Hepatitis C, Chronic/immunology , Adolescent , Child , Child, Preschool , Enzyme-Linked Immunosorbent Assay , Female , Hepatitis C, Chronic/virology , Humans , Intercellular Adhesion Molecule-1/blood , Interferon-alpha/blood , Interleukin-10/blood , Interleukin-12/blood , MaleABSTRACT
The samples of parotid gland saliva, collected from control human subjects and those taken from patients with head and neck cancers were submitted to the assay of protein concentration and kininogenase and amidolytic kallikrein activities. No patients with parotid gland tumours were included. The effect of pilocarpine stimulation on these parameters was studied. It was found that the saliva secreted by parotid gland of the investigated patients contains less protein and lower kininogenase activity in comparison to control subjects. Pilocarpine administration resulted in an increase of protein concentration and a decrease of kallikrein activity both in control and investigated subjects. Radiotherapy did not evoke any significant changes in spontaneously secreted saliva. The radiotherapy resulted in a progressive decrease of protein concentration and kallikrein activity in saliva secreted by pilocarpine stimulated glands. The kallikrein activity per mg of protein contained in spontaneously secreted saliva increased significantly during radiotherapy but it distinctly decreased in the saliva of pilocarpine-treated patients. It allows to conclude that the parotid glands do not lose their ability to synthesize and secrete kallikrein during radiotherapy of head and neck cancers.
Subject(s)
Head and Neck Neoplasms/physiopathology , Head and Neck Neoplasms/radiotherapy , Kallikreins/metabolism , Parotid Gland/radiation effects , Saliva/metabolism , Adolescent , Adult , Aged , Female , Humans , Kallikreins/radiation effects , Male , Middle Aged , Parotid Gland/drug effects , Parotid Gland/metabolism , Pilocarpine/pharmacology , Proteins/analysis , Saliva/drug effectsABSTRACT
In 222 patients treated in the Department of Infectious Diseases Medical School of Bydgoszcz, one carried out immunoenzymatic examinations to find out presence of HCV antibodies. Among them, there were 33NANBH patients as well as 32 diagnosed as CAH NANB origin, 55 chronic hemodialysis patients and finally 102 IVDU. It was pointed out that the patients suffering from acute and chronic hepatitis type NANB were often HCV infected. Drug addicts (IVDU) and chronic hemodialysis patients constitute high risk groups of these infections. It should be stressed that these infections are asymptomatic in just these groups of patients. One discussed some epidemiological and clinical aspects of 19 hepatitis C cases.
Subject(s)
Hepatitis C/diagnosis , Kidney Failure, Chronic/therapy , Renal Dialysis/adverse effects , Transfusion Reaction , Chronic Disease , Hepatitis B Antibodies/analysis , Hepatitis B Antibodies/immunology , Hepatitis B virus/immunology , Hepatitis B virus/pathogenicity , Hepatitis C/etiology , Hepatitis C/immunology , Humans , Kidney Failure, Chronic/complications , Risk FactorsABSTRACT
Investigations included a group 80 asymptomatic drug addicts. They were examined immunoenzyme method aiming at detection infection by HIV, HBV, HCV and HDV. Cases of seropositive HIV results were confirmed by means WB. In 68 examined patients serological evidence of virus HBV was discovered. In 60 of them one also found out coexisting HIV serological markers, in 51 of HCV markers. HDV antibodies were disclosed in 7 cases. Infection with hepatotropic viruses were more frequent in group of HIV(+) drug addicts.
Subject(s)
Acquired Immunodeficiency Syndrome/diagnosis , Hepatitis B/diagnosis , Hepatitis C/diagnosis , Hepatitis D/diagnosis , Substance Abuse, Intravenous/complications , Acquired Immunodeficiency Syndrome/etiology , Acquired Immunodeficiency Syndrome/immunology , Acquired Immunodeficiency Syndrome/transmission , Adolescent , Adult , Biomarkers , Female , HIV Antibodies/analysis , HIV-1/immunology , Hepacivirus/immunology , Hepatitis Antibodies/analysis , Hepatitis B/etiology , Hepatitis B/immunology , Hepatitis B/transmission , Hepatitis B virus/immunology , Hepatitis C/etiology , Hepatitis C/immunology , Hepatitis C/transmission , Hepatitis D/etiology , Hepatitis D/immunology , Hepatitis D/transmission , Hepatitis Delta Virus/immunology , Humans , Male , PolandABSTRACT
The existing in Bydgoszcz infectivity infrastructure was made available to AIDS infection risk groups. The AIDS infected patients make use of ambulatory and in-patient health service together with other sick people. Among 72 detected infections only 2 cases remain without any connection with drug addiction. In this paper one presented advantages of the accepted organisational model as well as the effects of its functioning.