[Multi-objective optimization for fuzzy controller in neuro-muscular rehabilitation]. / Optimizare multiobiectiv a controlerelor fuzzy in recuperarea neuro-musculara.

The multi-objective optimization problem could be generally formulated as minimization of vector objectives subject to a number of constraints and bounds. Among the non-derivative problems, genetic algorithms have been proved to be a good solution in addressing ill-posed problem. We applied the multi-objective optimization to fuzzy controller design in order to obtain a optimal solution that is often a compromise between different objectives. The application that are targeted in this paper is the e-health in neuromuscular rehabilitation using electromyographies. Because our application is implemented using a micro-controller with limited capabilities, that is flash memory, computational effort, and the clock frequency, the interest is to design the smallest fuzzy architecture possible in order to accomplish the objectives. The optimal set was used in order to achieves these objectives.

[E-health application for home monitoring of neuro-muscular rehabilitation]. / Aplicatie e-health pentru monitorizarea la domiciliu a recuperarii neuro-musculare.

In many medical fields the recovery of muscular activity or its improvement up to the level of the optimal parameters is required. Apart from the classical solution for rehabilitation (physical exercises) the use of electrical stimulation has become quite frequent of late. The paper presents an interface that detects the electromyographic (EMG) activity, assesses it, and generates appropriate electrical stimuli, by means of a specific type of fuzzy control system, in order to control the dynamics of the EMG. The proposed interface will detect the motion and muscular activity, it will evaluate and generate the electrical stimulus using a fuzzy system tuned by dynamic of motion. The application will transmit e-Health information to the physician via Internet, synthetic, at request using TCP/IP stack and SMS services for wireless communication.

[Normal and pathologic implication of cytokines]. / Implicatii normale si patologice ale citokinelor.

Cytokines involved in the immune process proof, also, the neurotransmitter role, being synthesized by various cells of the body, with specific genes participation. Cytokines can act on the some membrane receptor like the neurotransmitters, and they can produce diverse biological effects. Pro-inflammatory, anti-inflammatory or haematopoetic cytokines as those in the central nervous system can be identified by immunoassay and bioassay methods. Recent works show that the cytokines implication in hypothalamo-hypophyso-corticopsuprarenal and gonad axis have consequence on ACTH, corticoids and LH secretion, explaining the ovulatory and gestational disorders. Excessive or insufficient cytokines synthesis, at neuronal level (astrocytes, microglies), explains psychiatric disorders such as schizophrenia, depression, Alzheimer's disease; cytokines (interferon) long term use for the treatment of some diseases, produce irritability, anxiety, delirium, and confusion etc.

[EEG patterns in alcohol withdrawal syndrome]. / Activitatea bioelectrica cerebrala în abstinenta alcoolica.

The cerebral motor and cognitive behavior is obviously altered by chronic alcoholism, which generates significant morphological and biochemical changes. In turn, alcoholic withdrawal improves the cerebral blood supply, the psychological and motor behavior and the EEG appearance, especially in young alcoholics. Our study also underlines that alcoholic women develop a late improvement of the clinical and bioelectrical condition during the alcoholic withdrawal.

[The blood enzymatic antioxidative potential in bronchial asthma patients]. / Investigarea potentialului antioxidativ enzimatic sanguin la pacienti cu astm bronsic.

This study aims at assessing the ability of asthma patients to defend themselves against the noxious effects of oxidative stress, known being the inflammatory nature of this disorder. As the anti-radical defence ability of the body is reflected by the antioxidative potential of blood and tissues, our study was based on the determination of the activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and CAT/SOD and GPx/SOD ratios in the blood. Except for SOD, the activity of which was lower in asthma patients by -34.08%, CAT and GPx had values increased by +32.18%, respectively, with a resulting increase of CAT/SOD and GPx/SOD ratios. Our data, demonstrating a change in per-oxidants/antioxidants balance in favour of the first ones, seem to suggest that in the treatment of bronchial asthma the association of some compounds with antioxidants effects would be beneficial.

[The role of paraclinical studies in the diagnosis of hypomagnesemia spasmophilia]. / Rolul explorarilor paraclinice în diagnosticarea spasmofiliei hipomagneziemice.

Assuming that Ca+2 and Mg+2 play an important role in the cell (especially the neuronal and muscular ones) membrane excitability, this paper presents the place that the paraclinical specific investigations have in the proper diagnose of normal calcium serum level hypo-magnesium spasmophilia. A number of 52 patients presenting significant clinical spasmophilia, of age between 21 and 55 years old, from different professions and social classes, were selected for this study. Paraclinical investigations (spectrophotometry) showed a normal serum calcium level (an average of 9.22 mg%); also, a decrease of Mg+2 serum level (an average of 1.41 mg%) and normal levels for Na+ (3.04 g/l) and K+ (0.21 g/l). The electrophysiological investigations (EMG, EEG, VCN m, EKG) performed showed, on the EMG recordings, in 85% of the cases the presence of the typical spasmophilic repetitive discharges, increased when using compression ischemia and 3 minutes hyperventilation, while on the EEG recordings, most patients demonstrated the presence of diffuse or mainly frontal lobe cortical bioelectrical activity alteration, either in spontaneous conditions or after specific stimulation (3 minutes hyperventilation or SLI). The muscle bioelectrical activity was analyzed by mean of EMG recordings--a decrease of VCN m was detected on the SPE nerve (34.4 m/s) and also on the SPI nerve (34.2 m/s) The EKG recordings performed showed in 5% of the cases the presence of the ventricular repolarization disturbances (flat T waves). After receiving a proper treatment which included oral administration of calcium and magnesium gluconolactate, magnesium gluconolactate with B6 vitamin or Trimagant, there were important changes of all the studied parameters and so, as a specific therapy, we recommend the use of Mg+2 compounds, because it demonstrates a significant improvement of the clinical symptoms in spasmophilia and has no danger to precipitate in the body as Ca+2 exceeding does.

[The action of xanthinol nicotinate on the central and peripheral arterial pressure and on respiration in dogs]. / Actiunea xantinolului nicotinat asupra tensiunii arteriale centrale si periferice si asupra respiratiei la cîine.

The pharmaceutical trial in dogs on the influence the Romanian pharmaceutical product xanthinol nicotinate has on the cardiovascular system (central and peripheric blood pressure, venous pressure, EKG) and respiratory system rendered evident a hypotensive effect in direct ratio to the dose, prevalently peripheric, without significant changes in respiratory amplitude. It is concluded that the Romanian product has similar effects to those described in the literature for xanthinol nicotinate.

[Microcirculation study by video-monitored intravital microscopy]. / Studiul microcirculatiei prin microscopie intravitala monitorizata video.

As a result of a interdisciplinary team's work, the in vivo study of microcirculation by video monitoring systems, adapted to the optic microscopy, opens new perspectives for the fundamental as such for the clinical and pharmacological research. The multiple possibilities of image acquisition on video tapes, as well as on colour films, offers a variety of post processing of the images through dedicated computer based programs, in order to obtain a precise measurement of the changes occurring in the living tissues. Furthermore, this technical devices along with a proper directed health program, may be used as a modern diagnostic tool in populational screening.

[The effect of captopril on the coronary circulation in a clinical and experimental study]. / Influenta captoprilului asupra circulatiei coronariene. Studiu clinico-experimental.

Taking into account the well-known angiotensin II-induced coronary constriction, in a first series of experiments the effects of captopril were studied upon the rabbit, guinea pig and rat coronary circulation during perfusion with oxygenated Krebs-Henseleit solution at 37 degrees C under constant pressure and variable flow according to the Langendorf technique. The inhibition of angiotensin I to angiotensin II conversion enzyme with captopril (5-500 microgr./ml) resulted in a coronary dose dependent dilation as a consequence of a reduction in the basal coronary tonus. Testing the coronary distensibility by using pressure and flow variations revealed a significantly increased distensibility when the conversion enzyme was specifically blocked with captopril. The anginal threshold of the atrial electrostimulation was increased after captopril (25-50 mg i.v.) in 15 out of 18 patients with coronary insufficiency by a mean value of 17%, white the systolic dynamics was significantly better. The obtained results bring new arguments in favour of the intrinsic renin-angiotensin system participation in maintaining the basal vascular tonus and of the increased coronary distensibility in the presence of captopril as an inhibitor of the local synthesis of the vasoconstrictor angiotensin II.

Techniques for evidencing the respiratory patterns and their temporal shift.

To enhance the efficiency of de visu or automatic detection and analysis of of the respiratory patterns, new techniques are introduced to process the respiratory signals. These techniques include: the dynamical frequency analysis, spectral envelope detection, three-dimensional representation of the spectral envelopes, and the 'respirogram'.

Possible opioid participation in the analgesic effects of the renin-angiotensin system.

Using the tail-flick method in 45 rats with a chronic cannula stereotaxically implanted in the third ventricle, a rapid onset, dose related and short lasting analgesia was obtained after intracerebroventricular injection of Ang II 10-15 ng/kg or renin 0.03-0.1 U. Analgesic effects of the endogenous and exogenous Ang II are prevented by naloxone--1 mg/kg i.p. The inhibition of serotonin synthesis with PCPA--400 mg/kg/day i.p. for five days as well as the serotonin-receptor block with ketanserin 0.1 mg/kg i.p. partially prevent analgesic effects of Ang II and renin intracerebral administration. The increase of the pain perception threshold after infusing into the brain Ang II or renin points out a new functional consequence of the possible opioid participation in the central effects of renin-angiotensin system.

[New parameters of electrocardiotachographic (EKT) evaluation of the organovegetative reactivity]. / Noi parametri de evaluare electrocardiotahografica a reactivitatii neurovegetative.

The analysis of some EKT lines evolution obtained by some investigations on the organovegetative reactivity carried out in the Laboratory of physiology correlated with the different experimental stages led to the formulation of some original cardiotachographic (KTG) parameters which seem to have a peculiar usefulness within the framework of the investigation methods. Except for the routine KTG parameters under the form of instantaneous cardiac rhythm (ICR) and mean cardiac rhythm (MCR) another 5 indices can now be used: 1) frequency of the rhythm fluctuations (FRF); 2) vegetative lability index (VLI); 3) mean rhythm fluctuation (MRF); 4) latency of rhythm fluctuation (LRF) and 5) amplitude of rhythm fluctuation (ARF). Their introduction as part of the investigation methods for the neurovegetative system would permit a better outline both of the relative relationship. between the component parts of the reactive system (normotonic or distonic) and its receptivity and promptitute to the different neurohumoral or somato-viscero-motor interferences.