ABSTRACT
The important physiological role of calcium and magnesium ions is all over recognised, about a lot of enzymatic reactions. Magnesium deficit produce neuromuscular hyper-reactivity, psychic reactions, functional hypoparathyroidism, increase of K+ channels membranes permeability, while hypermagnesemia decrease Ach release from neuromuscular synapsis, with post-synaptic excitability decreasing. Using BEROCCA (Hoffman la Roche) 1 cp/day, 30 days at the teenagers with behaviour troubles and at a goup of pregnant women (trimester I-III) with paresthesia, irritability, sleeplessness, we observed an improve of clinical signs, increasing plasma Ca2+ and Mg2+. EEG and EMG prove the beneficial effects of pharmaceutical product BEROCCA.
Subject(s)
Calcium/pharmacology , Drugs, Investigational/pharmacology , Magnesium/pharmacology , Neuromuscular Blocking Agents/pharmacology , Neuromuscular Junction/drug effects , Administration, Oral , Adolescent , Adult , Ascorbic Acid/therapeutic use , Calcium/therapeutic use , Drug Combinations , Drugs, Investigational/therapeutic use , Electroencephalography , Electromyography , Female , Humans , Magnesium/therapeutic use , Male , Neuromuscular Blocking Agents/therapeutic use , Neuromuscular Diseases/drug therapy , Pregnancy , Treatment Outcome , Vitamin B Complex/therapeutic useABSTRACT
Exist many interactions of the endogenous system with dopaminergic, serotinergic, GABA--ergig, and glutamat--ergic, as well as the role of these interactions in mediating stress response, analgesia and in appearance the alcoholism. Thus pharmacological blockade of the endogenous opioid system by mu or delta opioid receptor antagonists prevents ethanol's activation of the dopamine system and reduces ethanol consumption. The role of genetic factors in alcohol dependency is recognized. The applicability of PET, SPECT, MRS, functional neuroimaging in the study have a very importance, for demonstrates the changes in regional cerebral blood flow at the alcoholics.
