ABSTRACT
A total of 100 hospitalized stroke patients and 30 healthy controls were included in a study aiming to determine the predictive role of ApoE genotype polymorphism for stroke outcome in the Turkish population. The most frequent ApoE genotype was epsilon3/3 reflecting Asian population polymorphic distribution. ApoE polymorphism in the Eastern Turkish population was found to be independent of stroke type, OSCP subtypes of infarction, localization of hemorrhage, severity of carotid artery stenosis, and resultant stroke outcome. Distinct polymorphic results in populations from nearby regions suggest a multifactorial pathogenesis and presence of very complex genetic factors in the development of stroke and stroke outcome.
Subject(s)
Apolipoproteins E/genetics , Brain Damage, Chronic/genetics , Stroke/genetics , Adult , Aged , Aged, 80 and over , Alleles , Brain Damage, Chronic/etiology , Case-Control Studies , Comorbidity , Female , Gene Frequency , Genetic Predisposition to Disease , Genotype , Humans , Hypertension/epidemiology , Lipoproteins, LDL/blood , Male , Middle Aged , Myocardial Ischemia/epidemiology , Prognosis , Prospective Studies , Recovery of Function , Risk Factors , Stroke/blood , Stroke/epidemiology , Treatment Outcome , Turkey/epidemiology , Young AdultABSTRACT
The purpose of the present study was to investigate the predictive role of apolipoprotein E genotypes for stroke-related risk factors in the Turkish population. Among 100 stroke patients and 30 healthy subjects included in the study, most frequent Apo E genotype was epsilon3/3, compatible with polymorphic distribution of Asian population. VLDL and triglyceride levels in epsilon2/4(+) subjects were higher than in epsilon2/4(-) patients. HDL and homocysteine levels were higher in epsilon4/4 (+) subjects than in epsilon4/4 (-) stroke patients. These results suggest that ApoE polymorphism in this population was not associated with any other demographic or clinical variables except for lipid profiles and homocysteine levels.
