Different aspects of virus persistence (review).

The article reviews different aspects of virus persistence in human organism. Persistence is a capability acquired and strengthened in the process of evolution of many viruses that is the means of maintenance of species. Viruses of measles, poliomyelitis, mite-like encephalitis, B and C hepatitis, herpes, retro and HIV viruses persist in human organism. Persistence is used by various viruses at various levels; they have different adaptive power and no different pathologic output. But in any case, the necessary condition is that virus should escape from elimination reactions of immune control system. At the same time, the important thing is not to save free virus but to save infected cell. While discussing long-term viral persistence, it is impossible to mark off distinctly the importance of biological participation of macroorganism and provoker in this process. The output of the relationship with infect cell is conditioned on the one hand by permissiveness of cell system, on the other hand by strain pathogen city. The details of attenuation mechanisms of microorganism's different reactions in cases of illness with the same strain are not known well yet. Although, it is clear that in chronic persistence the leading role still has immune system disbalance. In disbalance genesis of immunological equilibration virus-induced changes of immunocompetent cells are high.

[Oxidative processes in the cervical and vaginal epithelial tissue in patients with HPV infection].

Genital human papilloma virus (HPV) infection is the sexually transmitted disease. HPV induces the proliferation of epithelial cells. In the areas of viral inclusions vulvovaginal warts, papillomas and condylomas are developing. Some serotypes of HPV are known as a significant risk factor of cervical cancer. The aim of our study was to detect the conditions of oxidation processes in vaginal and cervical tissues in patients with HPV infection. According to our results, in patients with HPV, intensification of production of reactive forms of nitrogen and oxygen in vaginal and cervical tissues takes place which is the result of activation of leukocytes, other phagocyte cells and chaotic flow of blood in damaged tissue, as well as interchanging periods of hypoxia and reperfusion.