ABSTRACT
The method was successfully used in 32 children with diffuse and general peritonitis and it may be recommended for clinical practice. No complications resulting from using the method of interstitial electrophoresis were noted.
Subject(s)
Anti-Bacterial Agents/administration & dosage , Iontophoresis/methods , Peritonitis/drug therapy , Child , Evaluation Studies as Topic , Humans , Iontophoresis/adverse effects , Iontophoresis/instrumentationABSTRACT
Antibacterial properties of the Soviet drug nitazol which is a derivative of imidazole were studied. It was shown that nitazol in a dose of 4-8 micrograms/ml was highly active against gram-negative nonsporulating anaerobes, gram-positive anaerobic cocci and spore-forming Clostridia spp. Unlike metronidazole, it was efficient against both standard and clinical strains of facultative anaerobes such as E. coli, S. aureus and Klebsiella spp. isolated from patients with peritonitis and being poly-resistant to antibiotics. It was found in vitro that the antibacterial effect of nitazol was higher when it was used in combination with some antibiotics. It was demonstrated on experimental models of peritonitis caused by Staphylococcus spp. and E. coli in mice that nitazol used alone or in combination with gentamicin had a favourable effect on the animal survival and lifespan. The combination of nitazol with gentamicin was applied in the combined treatment of appendicular peritonitis in 80 children and its high therapeutic efficacy was stated. Nitazol is useful as an antibacterial drug in the combined treatment of children with purulent peritonitis.
Subject(s)
Disease Models, Animal , Escherichia coli Infections/drug therapy , Gentamicins/therapeutic use , Imidazoles/therapeutic use , Peritonitis/drug therapy , Staphylococcal Infections/drug therapy , Animals , Anti-Infective Agents/therapeutic use , Child , Drug Evaluation, Preclinical , Drug Therapy, Combination , Gentamicins/administration & dosage , Humans , Imidazoles/administration & dosage , MiceABSTRACT
The experimental-clinical investigations have demonstrated the high effectiveness of the native preparation Nitazole against the Gram-negative non-spore-forming anaerobic bacteria, Gram-positive anaerobic cocci, spore-forming Clostridium, certain facultative anaerobes. This permits to recommend it for the use as an antibacterial preparation for the treatment of peritonitis in children.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Appendicitis/complications , Peritonitis/drug therapy , Anti-Bacterial Agents/administration & dosage , Child , Drug Therapy, Combination , Gentamicins/administration & dosage , Humans , Peritonitis/etiology , Time FactorsABSTRACT
In children at the age under 3 years with different forms of acute purulent destructive pneumonia, the positive effect of troxevasin on the platelet aggregation correlating with the pronounced positive clinical effect was revealed.
