1.
Chem Commun (Camb)
; 46(10): 1625-7, 2010 Mar 14.
Article
in English
| MEDLINE
| ID: mdl-20177596
ABSTRACT
The combination of experimental with theoretical CD spectroscopy allows the observation of stereoselective helical folding in a self-assembled capsule.
2.
Bioorg Med Chem
; 17(7): 2842-51, 2009 Apr 01.
Article
in English
| MEDLINE
| ID: mdl-19278853
ABSTRACT
In the present study we synthesized 36 coumarin and 2H-chromene derivatives applying a recently developed umpoled domino reaction using substituted salicylaldehyde and alpha,beta-unsaturated aldehyde derivatives as starting compounds. In radioligand binding studies 5-substituted 3-benzylcoumarin derivatives showed affinity to cannabinoid CB(1) and CB(2) receptors and were identified as new lead structures. In further GTPgammaS binding studies selected compounds were shown to be antagonists or inverse agonists.
Subject(s)
Coumarins/chemical synthesis , Coumarins/pharmacology , Receptor, Cannabinoid, CB1/agonists , Receptor, Cannabinoid, CB1/antagonists & inhibitors , Receptor, Cannabinoid, CB2/agonists , Receptor, Cannabinoid, CB2/antagonists & inhibitors , Animals , Cell Line , Coumarins/chemistry , Drug Inverse Agonism , Humans , Rats , Receptor, Cannabinoid, CB1/metabolism , Receptor, Cannabinoid, CB2/metabolism , Species Specificity , Structure-Activity Relationship
3.
J Comb Chem
; 7(2): 147-69, 2005.
Article
in English
| MEDLINE
| ID: mdl-15762741