Increased static and decreased capacity oxidation-reduction potentials in plasma are predictive of metabolic syndrome.

Electric conductivity in plasma is the balance between oxidized and reduced molecules (static Oxidation-Reduction Potential, sORP) and the amount of readily oxidizable molecules (capacity ORP, cORP). Adults with metabolic syndrome (MetS) have increased inflammation, dyslipidemia and oxidative stress; therefore, participants with MetS were hypothesized to have higher plasma sORP and lower cORP than those measures in healthy adults. Heparin-anticoagulated plasma from healthy and age- and gender-matched individuals with MetS (BMI: 22.6±0.7 vs. 37.7±3.0kg/m2, respectively) was collected in the fasting state at 0, 24, 48, and 72h during each of four separate interventions in a clinical trial. At baseline, plasma sORP was 12.4% higher (P=0.007), while cORP values were less than half (41.1%, P=0.001) in those with MetS compared with healthy participants. An sORP >140mV detected MetS with 90% sensitivity and 80% specificity, while a cORP <0.50µC detected MetS with 80% sensitivity and 100% specificity. sORP and cORP values in participants with MetS compared with healthy adults were linked to differences in waist circumference and BMI; in plasma markers of dyslipidemia (triglycerides, HDL-cholesterol, and oxidized LDL-cholesterol) and inflammation (C-reactive protein, IL-10); as well as with urinary markers of lipid peroxidation (e.g., 2,3-dinor-5,6-dihydro-8-iso-PGF2α; 2,3-dinor-8-iso-PGF2α). Higher sORP values are a robust indicator of metabolic stress, while lower cORP values act as an indicator of decreased metabolic resilience.

Análisis de los avisos internos al equipo de guardia del área médica en un hospital general / Analysis of the internal notices to the emergency team of the medical area in a general hospital

Fundamento: Valorar la frecuencia y características de las urgencias internas. Pacientes y métodos: Se recogen los avisos diarios al equipo de guardia durante un mes, analizando las características clínicas y epidemiológicas. Resultados: Se documentaron 341 avisos, con una media diaria superior en días festivos. Se trata de problemas fundamentalmente clínicos (78 por ciento), variables según el servicio. Se realizaron exploraciones complementarias al 44 por ciento de los pacientes, y se indicaron modificaciones terapéuticas en el 77 por ciento. Conclusiones: Las urgencias internas suponen un apartado importante de la labor asistencial de los equipos de guardia, y plantean importantes valoraciones diagnósticas y terapéuticas. (AU)