Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 4 de 4
Filter
Add more filters










Database
Language
Publication year range
1.
Eur J Pharm Biopharm ; 191: 265-275, 2023 Oct.
Article in English | MEDLINE | ID: mdl-37657613

ABSTRACT

Dry powder inhalers (DPI) are important for topical drug delivery to the lungs, but characterising the pre-aerosolised powder microstructure is a key initial step in understanding the post-aerosolised blend performance. In this work, we characterise the pre-aerosolised 3D microstructure of an inhalation blend using correlative multi-scale X-ray Computed Tomography (XCT), identifying lactose and drug-rich phases at multiple length scales on the same sample. The drug-rich phase distribution across the sample is shown to be homogeneous on a bulk scale but heterogeneous on a particulate scale, with individual clusters containing different amounts of drug-rich phase, and different parts of a carrier particle coated with different amounts of drug-rich phase. Simple scalings of the drug-rich phase thickness with carrier particle size are used to derive the drug-proportion to carrier particle size relationship. This work opens new doors to micro-structural assessment of inhalation powders that could be invaluable for bioequivalence assessment of dry powder inhalers.


Subject(s)
Drug Carriers , Drug Delivery Systems , Powders/chemistry , Drug Carriers/chemistry , Administration, Inhalation , Drug Delivery Systems/methods , Lactose/chemistry , Dry Powder Inhalers/methods , Excipients/chemistry , Tomography, X-Ray Computed , Particle Size , Aerosols/chemistry
SELECTION OF CITATIONS
SEARCH DETAIL
...