1.
Chem Commun (Camb)
; 50(5): 515-7, 2014 Jan 18.
Article
in English
| MEDLINE
| ID: mdl-24247159
ABSTRACT
A series of abasic site-binding ligands conjugated with cyanine dyes have been developed for "off-on" fluorescence sensing of an orphan nucleobase in DNA duplexes and DNA-RNA hybrids.
Subject(s)
Carbocyanines/chemistry , DNA/chemistry , Fluorescent Dyes/chemistry , Ligands , RNA/chemistry , Benzothiazoles/chemistry , DNA/metabolism , Naphthyridines/chemistry , Nucleic Acid Conformation , Quinolines/chemistry , RNA/metabolism , Spectrometry, Fluorescence
2.
Chem Commun (Camb)
; 49(85): 9983-5, 2013 Nov 04.
Article
in English
| MEDLINE
| ID: mdl-24042469
ABSTRACT
We report on a new fluorescent ligand, 2,4-diamino-6,7-dimethylpteridine, that can strongly and selectively bind to an orphan cytosine opposite an abasic site in RNA duplexes. We describe a significant effect of the substituents attached to the pteridine ring on the binding behavior in comparison with a structurally-similar pteridine derivative.
