A Random Forest-based Classifier for MYCN Status Prediction in Neuroblastoma using CT Images.

Neuroblastoma (NB) is the most common extracranial solid tumor in childhood. Genomic amplification of MYCN is associated with poor outcomes and is detected in 16% of all NB cases. CT scans and MRI are the imaging techniques recommended for diagnosis and disease staging. The assessment of imaging features such as tumor volume, shape, and local extension represent relevant prognostic information. Radiogenomics have shown powerful results in the assessment of the genotype based on imaging findings automatically extracted from medical images. In this work, random forest was used to classify the MYCN amplification using radiomic features extracted from CT slices in a population of 46 NB patients. The learning model showed an area under the curve (AUC) of 0.85 ± 0.13, suggesting that radiomic-based methodologies might be helpful in the extraction of information that is not accessible by human naked eyes but could aid the clinicians on the diagnosis and treatment plan definition. Clinical relevance - This approach represents a random forest-based model to predict the MYCN amplification in NB patients that could give a faster, earlier, and repeatable analysis of the tumor along the time.

Diabetes: a silent player in musculoskeletal interventional radiology response.

Diabetes has an important role in the development of several musculoskeletal disorders, such as adhesive capsulitis of the shoulder (ACs) and stenosing flexor tenosynovitis of the finger (SfTf). The etiopathophysiology of ACs and SfTf in diabetic patients is associated with both chronic hyperglycemia, increased amounts of visceral adiposity and chronic inflammation. Chronic hyperglycemia stimulates the creation of cross-links between collagen molecules, impairing degradation and resulting in the build-up of excessive collagen deposits in the cartilage, ligaments, tendon sheaths and tendons. Increased adipocytes in diabetic patients secrete proteins and cytocines such as TNF-α, IL-6 and IL-13 which result in overproduction of pro-inflammatory factors, destruction of normal tissue architecture and fibrosis. Both hyperglycemia and adipocytes inhibit efferocytosis, limiting natural resolution. Recently, multiple image-guided interventional radiology musculoskeletal treatment options have been developed, such as ultrasound-guided glenohumeral capsule hydrodistension for ACs and ultrasound-guided percutaneous pulley release for trigger finger. Diabetes can negatively influence outcomes in patients with ACs and SfTf and may impact the decision of which specific procedure technique should be employed. Further studies are necessary to define how diabetes influences response to interventional radiology treatments of these disorders, as well as the extent to which control of blood sugar levels can contribute towards the personalization and optimization of patient follow up.

Crossed renal ectopia with fusion. An incidental diagnosis. / Ectopia renal cruzada con fusión. Un diagnóstico fortuito.

A 21-year-old woman with an uneventful past medical history presented to the emergency department with acute right inferior abdominal pain...

Una mujer de 21 años de edad con un historial médico sin incidentes acude al servicio de urgencias con un dolor abdominal inferior derecho agudo...

Ectopia renal cruzada con fusión. Un diagnóstico fortuito / Crossed renal ectopia with fusion. An incidental diagnosis

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Solid pseudopapillary tumor of the pancreas in a child: imaging findings with diffusion-weighted MR imaging.

CONTEXT: Solid pseudopapillary tumor of the pancreas is a rare tumor more common in young girls and rare in males. CASE REPORT: We present a case of a solid pseudopapillary tumor of the pancreas in a 13-year-old boy, with typical imaging features. CONCLUSIONS: Our case report specifically illustrates the potential of diffusion-weighted imaging findings on solid pseudopapillary tumor in pediatric patients.

Hypertrophic pyloric stenosis: tips and tricks for ultrasound diagnosis.

We describe a systematic approach to the ultrasound (US) examination of the antropyloric region in children. US is the modality of choice for the diagnosis of hypertrophic pyloric stenosis (HPS). The imaging features of the normal pylorus and the diagnostic findings in HPS are reviewed and illustrated in this pictorial essay. Common difficulties in performing the examination and tips to help overcome them will also be discussed. Main Messages • Hypertrophic Pyloric Stenosis is defined by thickening of the muscular layer and failure in relaxation of the pyloric canal. • The main diagnostic criterion is a measurement of more than 3mm in thickness of the muscular layer. • Abnormal elongation of the canal is characterised as greater than 12 mm in length.