Subject(s)
Adenocarcinoma/diagnosis , Ampulla of Vater , Common Bile Duct Neoplasms/diagnosis , Clavicle , Female , Humans , Lymphatic Metastasis , Middle Aged , Weight LossABSTRACT
The clinical characteristics and evolution of 15 patients with Diffuse Pulmonar Hemorrhage Syndrome are reviewed. According to etiology diseases are classified in three groups: 1) Basal Antimembrane Antibodies disease (66.6%), 2) Vasculitis-Granulomatosis (24.6%), and 3) Idiopathic (6.6%). Pulmonary Hemorrhage was the first manifestation of the primary disease in 80% of patients and was present in 100% of those patients with anemia and opacities in chest x-Ray and in 73% of those with renal insufficiency, nephritic sediment and respiratory insufficiency. To reach the etiological diagnosis, invasive techniques were needed in order to obtain samples for the pathology exam. Three patients died (20%) and 7 had a relapse (46.6%) during the first year. It is underlined the need of an empirical aggressive treatment with steroids and immune-suppress drugs before reaching the final etiological treatment.
Subject(s)
Hemorrhage , Lung Diseases , Adolescent , Adult , Aged , Autoantibodies , Autoimmune Diseases/complications , Basement Membrane/immunology , Female , Granulomatosis with Polyangiitis/complications , Hemorrhage/diagnosis , Hemorrhage/etiology , Hospitals , Humans , Lung Diseases/diagnosis , Lung Diseases/etiology , Male , Middle Aged , Retrospective Studies , Spain , Syndrome , Vasculitis/complicationsSubject(s)
Calcinosis/etiology , Dermatomyositis/complications , Muscular Diseases/etiology , Child , Female , HumansSubject(s)
Amyloidosis , Autonomic Nervous System Diseases , Peripheral Nervous System Diseases , Adult , Humans , Male , Middle Aged , PrognosisABSTRACT
In this study, we examine with attention the latest etiopathogenic findings of this protein-like group of diseases in which even today, exist unclear and controversial aspects. We analyze from an immunological point of view either the role of immunocomplexes and the role of cell-mediated immunity, standing out the direct antibodies-mediated injury, especially emphasizing antineutrophil antibodies. Next, we describe steps and attitudes to be taken when facing one of these diseases diagnosis, including not only suspect, confirmation and degree of spreading, but also setting behaviour guidelines that make feasible the search of associate diseases and discarding other kind of diseases with which may arise some confusion.
Subject(s)
Vasculitis/etiology , Antibodies/immunology , Humans , Immune Complex Diseases/complications , Immune Complex Diseases/immunology , Immunity, Cellular/immunology , Vasculitis/diagnosis , Vasculitis/immunologyABSTRACT
Diffuse pulmonary hemorrhage syndrome (DPHS) is reviewed and classified according to the international classification. We analyse the more characteristic features, as well as the most appropriate diagnosis methods which ensure early and effective treatment. We conclude by proposing the therapeutic attitude to be taken for DPHS.
Subject(s)
Hemorrhage/diagnosis , Lung Diseases/diagnosis , Combined Modality Therapy , Diagnosis, Differential , Hemorrhage/etiology , Hemorrhage/therapy , Humans , Lung Diseases/etiology , Lung Diseases/therapy , SyndromeABSTRACT
Hypercalcemia (HC) is a frequent complication of tumoral disease which should always be treated, tumor therapy being the best treatment. Occasionally, it can prove to be a medical emergency and should be treated without delay, especially where high risk patients are concerned. Sometimes, the treatment is not successful due to the fact that the drugs used in acute crises, although effective, have high toxicity; meanwhile, the drugs used for chronic HC lack the desired level of effectiveness and, in addition, tolerance problems are also implicated. In this paper, we consider the therapeutic schedule, based on physiopathologic mechanisms; and, the various drugs presently being used are reviewed. The therapeutic attitude to be followed during HC is indicated.
