ABSTRACT
The ethanol extracts of Wikstroemia foetida var. oahuensis and Wikstroemia uva-ursi showed antitumor activity against the P-388 lymphocytic leukemia (3PS) test system One PS-active constituent of both plants was the lignan wikstromol. Several inactive compounds were identified as daphnoretin, pinoresinol, and syringaresinol.
Subject(s)
Antineoplastic Agents, Phytogenic/isolation & purification , Furans/isolation & purification , Animals , Antineoplastic Agents, Phytogenic/therapeutic use , Chemical Phenomena , Chemistry , Furans/therapeutic use , Leukemia, Experimental/drug therapy , LignansABSTRACT
Bouvardin, a bicyclic hexapeptide, was found to exhibit a solvent-dependent conformational distribution. HPLC was utilized to separate the two different conformers whose distribution ratio was dependent on the solvent of injection.
Subject(s)
Peptides, Cyclic/isolation & purification , Chromatography, High Pressure Liquid/methods , Protein Conformation , StereoisomerismABSTRACT
An ethanol extract of Baileya pauciradiata exhibited cytotoxic activity against the human epidermoid carcinoma of the nasopharynx and the lymphocytic leukemia test systems. Two constituents responsible for this activity were isolated and identified as odoratin and paucin. Their identities were proven by IR, PMR, and mass spectral data; elemental analysis; preparation of their acetates; and melting-point determinations. Odoratin was confirmed by comparison with an authentic sample.
Subject(s)
Antineoplastic Agents, Phytogenic/isolation & purification , Sesquiterpenes/isolation & purification , Animals , Antineoplastic Agents, Phytogenic/pharmacology , Glycosides/isolation & purification , Glycosides/pharmacology , Humans , Lactones/isolation & purification , Lactones/pharmacology , Neoplasms, Experimental/drug therapy , Sesquiterpenes/pharmacologySubject(s)
Antineoplastic Agents, Phytogenic/isolation & purification , Oligopeptides/isolation & purification , Plants, Medicinal/analysis , Antineoplastic Agents, Phytogenic/therapeutic use , Crystallography , Models, Molecular , Neoplasms, Experimental/drug therapy , Oligopeptides/pharmacology , Phytotherapy , Protein ConformationABSTRACT
The triterpene acetylaleuritolic acid was isolated from Jatropha macrorhiza (Euphorbiaceae) and showed tumor-inhibitory properties toward the P-388 lymphocytic leukemia test system. The compound was identified by means of IR, PMR, and mass spectrometry and by its transformation into the known methyl acetyloleanolate.
Subject(s)
Antineoplastic Agents, Phytogenic/isolation & purification , Plants, Medicinal/analysis , Triterpenes/isolation & purification , Animals , Antineoplastic Agents, Phytogenic/pharmacology , Chemical Phenomena , Chemistry , Leukemia, Experimental/physiopathology , Triterpenes/pharmacologyABSTRACT
The ethanol extract of Michelia champaca and the petroleum ether extract of Talauma ovata showed activity toward the human epidermoid carcinoma of the nasopharynx test system. The active constituents were sesquiterpene lactones, identified as parthenolide (C15H20O3) and costunolide (C15H20O2). Their identities were proven by elemental analyses, PMR, IR, and mass spectral data, melting-point and mixed melting-point determinations, and comparisons with authentic samples and spectra.
