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1.
Prenat Diagn ; 12(6): 535-9, 1992 Jun.
Article in English | MEDLINE | ID: mdl-1513757

ABSTRACT

Diastematomyelia is a structural anomaly which concerns primarily the spine and secondarily the nervous structures contained in it. A case of early prenatal diagnosis (20th week) by ultrasound of diastematomyelia with associated diplomyelia in a diabetic woman is reported. Radiological and pathological examination of the fetus after therapeutic abortion confirmed the diagnosis.


Subject(s)
Pregnancy in Diabetics/diagnostic imaging , Spina Bifida Occulta/diagnostic imaging , Ultrasonography, Prenatal , Abortion, Therapeutic , Adult , Diabetes Mellitus, Type 1/complications , Female , Humans , Hyperglycemia/complications , Pregnancy , Radiography , Spina Bifida Occulta/etiology
2.
Int J Cardiol ; 34(2): 179-87, 1992 Feb.
Article in English | MEDLINE | ID: mdl-1737669

ABSTRACT

To determine whether acute myocardial ischaemia induced by dynamic exercise can lead to changes in plasma levels of atrial natriuretic factor, we performed symptom-limited bicycle electrocardiographic tests in 20 males with recent acute myocardial infarction and in 8 control males. Ten patients developed exercise-induced myocardial ischaemia and 10 patients did not. There were no significant differences between the two groups with regard to age, site of myocardial infarction, urinary sodium, atrial sizes, radionuclide left ventricular ejection fraction, workload, baseline and peak-exercise heart rate, baseline and peak-exercise rate-pressure product, duration of exercise. Also baseline atrial natriuretic factor concentrations were similar in both groups (ischaemic patients: 34.51 +/- 15.73 pg/ml; nonischaemic patients: 27.17 +/- 8.74 pg/ml, NS), while peak-exercise atrial natriuretic factor concentrations were higher in patients with exercise-induced myocardial ischaemia (112.31 +/- 35.5 pg/ml) than in the others (80.46 +/- 23.43 pg/ml) (P less than 0.05). After 15 minutes of recovery, plasma atrial natriuretic factor levels were still raised only in the ischaemic patients (63.3 +/- 15.44 pg/ml, P less than 0.01), returning to baseline after 30 minutes in both groups. In control subjects, the behaviour of atrial natriuretic factor resembled that of the patients without exercise-induced ischaemia, with a significant increase at peak-exercise (from baseline levels of 23.1 +/- 10.5 pg/ml to peak-exercise levels of 91.3 +/- 14.5 pg/ml, P less than 0.0005) and a rapid return to baseline levels after 15 minutes of recovery (28.5 +/- 10.6 pg/ml, NS).(ABSTRACT TRUNCATED AT 250 WORDS)


Subject(s)
Coronary Disease/blood , Exercise/physiology , Myocardial Infarction/blood , Natriuretic Agents/blood , Adult , Coronary Disease/etiology , Coronary Disease/physiopathology , Heart Atria/metabolism , Hemodynamics , Humans , Male , Middle Aged , Myocardial Infarction/physiopathology , Natriuretic Agents/metabolism
3.
Am J Hypertens ; 4(11): 880-4, 1991 Nov.
Article in English | MEDLINE | ID: mdl-1838690

ABSTRACT

In order to evaluate the effects of atrial natriuretic factor (ANF) infusion on plasma insulin (IRI) in hypertension, 32 essential hypertensives (aged 40 to 62 years) were studied. After 1 week of pharmacologic washout under normal sodium intake (120 mEq of Na+/day), patients were randomly assigned to receive either ANF (0.04 micrograms/kg/min) or its vehicle (50 mL of isotonic saline) over a 60-min period in supine position. Plasma IRI and glucose were measured at -60, 0, 20, 40, 60, 120, 180, and 240 min (infusion time: from 0 to 60 min). Plasma levels of IRI and glucose did not change significantly during ANF infusion. On the contrary, after ANF discontinuation plasma IRI rose from levels of 13.5 +/- 6.4 microU/mL at 60 min to values of 20.1 +/- 11.3 microU/mL at 240 min (P less than .0001 v time 0). Plasma glucose showed a similar behavior, increasing from values of 100.4 +/- 5.0 mg/dL at 60 min to values of 120.0 +/- 5.1 mg/dL at 240 min (P less than .02 v time 0). Our findings suggest that ANF did not influence insulin release in hypertensives. The increase of plasma glucose and IRI observed after ANF discontinuation could be due to the relapse of sympathetic activity, suppressed during ANF infusion.


Subject(s)
Atrial Natriuretic Factor/pharmacology , Hypertension/blood , Insulin/blood , Adult , Atrial Natriuretic Factor/administration & dosage , Blood Glucose/analysis , Blood Pressure/drug effects , Blood Pressure/physiology , Heart Rate/drug effects , Heart Rate/physiology , Humans , Hypertension/physiopathology , Infusions, Intravenous , Male , Middle Aged , Potassium/blood , Sodium/blood
4.
Ann Ital Med Int ; 6(4): 369-74, 1991.
Article in Italian | MEDLINE | ID: mdl-1804283

ABSTRACT

Since the reduced kallikrein excretion demonstrated in essential hypertension suggested the possibility of an impairment in the renal kallikrein-kinin system, we decided to evaluate the efficacy and safety of oral kallikrein administration (glandular kallikrein derived from porcine pancreas) in 30 essential hypertensive subjects (21 males, 9 females, age range 34-62 years). Twenty subjects took 150 IU kallikrein t.i.d. for eight days; during this period their sodium intake remained normal (120 mEq Na+/die). Ten subjects took placebo. After the trial period, urinary kallikrein in the active group increased from 0.9 +/- 0.4 U/24 h (normal value greater than 1.2 U/24 h) to 1.6 +/- 1 U/24 h (p less than 0.05); systolic and diastolic blood pressure decreased respectively from 154.6 +/- 13.8 mmHg to 140.3 +/- 12.5 mmHg (p less than 0.01) and from 92.5 +/- 1.5 mmHg to 86 +/- 3.9 mmHg (p less than 0.025); urinary sodium and potassium excretion increased respectively from 96.7 +/- 17 mEq/24 h to 119.1 +/- 32.3 mEq/24 h (p less than 0.05) and from 36.7 +/- 11 mEq/24 h to 43.5 +/- 12.8 mEq/24 h (p less than 0.05). One patient in the kallikrein group suffered a transient episode of gastric pain. No modifications of the parameters evaluated were observed in the placebo group. We conclude that kallikrein has a mild hypotensive effect in hypertensive subjects and is generally well-tolerated. Its antihypertensive effect is probably due to the sodiuretic action of the substance.


Subject(s)
Hypertension/drug therapy , Kallikreins/administration & dosage , Administration, Oral , Adult , Blood Pressure/drug effects , Diuresis/drug effects , Drug Evaluation , Drug Tolerance , Female , Humans , Hypertension/physiopathology , Hypertension/urine , Kallikreins/adverse effects , Male , Middle Aged
5.
Clin Exp Obstet Gynecol ; 10(4): 171-5, 1983.
Article in English | MEDLINE | ID: mdl-6671317

ABSTRACT

The Authors evaluate a certain number of patients presenting primary or secondary infertility, in the search of any emotional problem which could be responsible for it. While it is hard to demonstrate the psychological origin in some cases of infertility and to quantify its real incidence, the Authors point out the importance of ruling out any psychological factor at the beginning of the work-up for the infertile couple and particularly while ascertaining the tubal patency through the hysterosalpingography, a diagnostic technique which can be very stressing for women.


Subject(s)
Fallopian Tube Patency Tests , Infertility, Female/psychology , Psychophysiologic Disorders/diagnosis , Adult , Female , Humans , Hysterosalpingography , Infertility, Female/diagnosis
6.
Int J Artif Organs ; 5(3): 145-7, 1982 May.
Article in English | MEDLINE | ID: mdl-7107048

ABSTRACT

The aim of our work was to evaluate the immediate effects of acetate-dialysis in patients with normal renal and respiratory function. For this purpose pH, pO2, pCO2 and HCO3- were monitored in arterial blood before dialysis, after 60, 120, 180 mns and at the end of each treatment in two groups of patients on chronic hemodialysis, a first group of schizophrenic patients and a second group of uremic patients. In the first group of patients the predialytic values were in the normal range. After hemodialysis HCO3- and pCO2 significantly decreased, both these changes were associated with a stable pH. The pO2 significantly decreased after 60 mns of dialysis. At the end of dialysis the pO2 increased without significant variation compared to predialytic values. In conclusion in non-uremic hemodialysis patients metabolic acidosis due to the loss of bicarbonate through the membrane is compensated by respiratory alkalosis. This respiratory alkalosis is not due to hypoventilation secondary to respiratory centre inhibition, but is mainly due to the pCO2 loss through the dialysis membranes.


Subject(s)
Acetates/therapeutic use , Acid-Base Equilibrium , Oxygen/blood , Renal Dialysis , Acid-Base Imbalance/therapy , Acidosis/etiology , Adult , Alkalosis, Respiratory/etiology , Blood , Blood Gas Analysis , Female , Humans , Male , Middle Aged , Partial Pressure , Renal Dialysis/adverse effects , Schizophrenia/blood , Schizophrenia/therapy , Ultrafiltration , Uremia/blood , Uremia/therapy
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