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1.
Am Surg ; 89(5): 1682-1687, 2023 May.
Article in English | MEDLINE | ID: mdl-35098740

ABSTRACT

BACKGROUND: Dedicated trauma intensive care units (ICUs) staffed by surgical intensivists lead to better patient outcomes. Increased length of stay (LOS) leads to worse outcomes. Little research has focused on the effect of dedicated trauma medical-surgical units or ICU/medicalsurgical systems. In 2018, our Level 1 trauma center transitioned from 3 non-dedicated levels of care (ICU/stepdown unit/medical-surgical) to 2 dedicated levels of care (ICU/medical-surgical). Our objective was to look at patient outcomes pre- and post-intervention. METHODS: Retrospective analysis of trauma registry data was performed on patients (age ≥18) admitted to the trauma service at a Level 1 rural trauma center over 46-months. In the pre-intervention group, step down and medical-surgical patients were combined as "Non-ICU" for analysis. Standard statistical analysis was performed. RESULTS: Analysis included 6103 patients. The group demographics were similar, except pre-intervention patients had higher ISS and fewer comorbidities. Emergency department LOS decreased from 30 versus 13.9% (P < .0001) and 15.9 versus 5.8% (P < .0001) for greater than 3 and 6 hours, respectively. Median LOS decreased for all patients (P < .0001). Mortality dropped from 9.0 versus 5.5% (P = .0009) for ICU and 1.7 versus 0.26% (P = .0013) for non-ICU patients. Overall patient mortality was level at 3.7%. Inpatient complications dropped from 9.9 versus 8.5% (P = .07). Unplanned ICU readmissions were unchanged (P = .4169). For patients with 3+ comorbidities, overall LOS dropped by 2 days (P < .0001) and home discharge increased from 42.8 versus 51% (P < .0001). CONCLUSION: Implementation of 2 levels of dedicated care has decreased ED and hospital LOS for all trauma patients without increasing mortality or complications. Patients with extensive comorbidities saw the most improvements.


Subject(s)
Emergency Service, Hospital , Intensive Care Units , Humans , Infant , Retrospective Studies , Hospital Mortality , Trauma Centers , Length of Stay
2.
J Trauma Acute Care Surg ; 91(1): 234-240, 2021 07 01.
Article in English | MEDLINE | ID: mdl-34144566

ABSTRACT

BACKGROUND: Antimicrobial guidance for common bile duct (CBD) stones is limited. We sought to examine the effect of antibiotic duration on infectious complications in patients with choledocholithiasis and/or gallstone pancreatitis. METHODS: We performed a post hoc analysis of a prospective, observational, multicenter study of patients undergoing same admission cholecystectomy for choledocholithiasis and gallstone pancreatitis between 2016 and 2019. We excluded patients with cholangitis and/or cholecystitis. Patients were divided into groups based on duration of antibiotics: prophylactic (<24 hours) or prolonged (≥24 hours). We analyzed these two groups in the preoperative and postoperative periods. Outcomes included infectious complications, acute kidney injury (AKI), and hospital length of stay (LOS). RESULTS: There were 755 patients in the cohort. Increasing age, CBD diameter, and a preoperative endoscopic retrograde cholangiopancreatography (odds ratio, 1.91; 95% confidence interval, 1.34-2.73; p < 0.001) significantly predicted prolonged preoperative antibiotic use. Increasing age, operative duration, and a postoperative endoscopic retrograde cholangiopancreatography (odds ratio, 4.8; 95% confidence interval, 1.85-13.65; p < 0.001) significantly predicted prolonged postoperative antibiotic use. Rates of infectious complications were similar between groups, but LOS was 2 days longer for patients receiving overall prolonged antibiotics (p < 0.0001). Patients with AKI received two more days of overall antibiotic therapy (p = 0.02) compared with those without AKI. CONCLUSION: Rates of postoperative infectious complications were similar among patients treated with a prolonged or prophylactic course of antibiotics. Prolonged antibiotic use was associated with a longer LOS and AKI. LEVEL OF EVIDENCE: Therapeutic, Level IV.


Subject(s)
Anti-Bacterial Agents/therapeutic use , Cholecystectomy/adverse effects , Choledocholithiasis/surgery , Pancreatitis/surgery , Postoperative Complications/epidemiology , Adult , Aged , Cholangiopancreatography, Endoscopic Retrograde , Common Bile Duct/surgery , Drug Administration Schedule , Female , Humans , Length of Stay/statistics & numerical data , Logistic Models , Male , Middle Aged , Postoperative Complications/prevention & control , Preoperative Care , Prospective Studies , United States
3.
Plants (Basel) ; 9(12)2020 Nov 24.
Article in English | MEDLINE | ID: mdl-33255180

ABSTRACT

Manganese (Mn) toxicity is a very common soil stress around the world, which is responsible for low soil fertility. This manuscript evaluates the effect of the endophytic bacterium Pseudomonas sp. Q1 on different rhizobial-legume symbioses in the absence and presence of Mn toxicity. Three legume species, Cicer arietinum (chickpea), Trifolium subterraneum (subterranean clover), and Medicago polymorpha (burr medic) were used. To evaluate the role of 1-aminocyclopropane-1-carboxylate (ACC) deaminase produced by strain Q1 in these interactions, an ACC deaminase knockout mutant of this strain was constructed and used in those trials. The Q1 strain only promoted the symbiotic performance of Rhizobium leguminosarum bv. trifolii ATCC 14480T and Ensifer meliloti ATCC 9930T, leading to an increase of the growth of their hosts in both conditions. Notably, the acdS gene disruption of strain Q1 abolished the beneficial effect of this bacterium as well as causing this mutant strain to act deleteriously in those specific symbioses. This study suggests that the addition of non-rhizobia with functional ACC deaminase may be a strategy to improve the pasture legume-rhizobial symbioses, particularly when the use of rhizobial strains alone does not yield the expected results due to their difficulty in competing with native strains or in adapting to inhibitory soil conditions.

4.
Surgery ; 168(1): 62-66, 2020 07.
Article in English | MEDLINE | ID: mdl-32466829

ABSTRACT

BACKGROUND: We sought to prospectively identify risk factors for biliary complications and 30-day readmission after cholecystectomy for choledocholithiasis and gallstone pancreatitis across multiple US hospitals. METHODS: We performed a prospective, observational study of patients who underwent same admission cholecystectomy for choledocholithiasis and gallstone pancreatitis between 2016 and 2019 at 12 US centers. Patients with prior history of endoscopic retrograde cholangiopancreatography or diagnosis of cholangitis were excluded. We used logistic regression to determine associations between preoperative demographics, labs, and imaging on primary outcomes: postoperative biliary complications and 30-day readmission. RESULTS: There were 989 patients in the cohort. There were 16 (1.6%) patients with postoperative biliary complications, including intra-abdominal abscesses, endoscopic retrograde cholangiopancreatography-induced pancreatitis, and biliary leaks. Increasing operative time (odds ratio 1.01, 95% confidence interval 1.00-1.01, P = .02), worsening leukocytosis (odds ratio 1.16, 95% confidence interval 1.07-1.25, P = .0002), and jaundice (odds ratio 3.25, 95% confidence interval 1.01-10.42, P = .04) were associated with postoperative biliary complications. There were 36 (3.6%) patients readmitted within 30 days owing to a surgical complication. A prior postoperative biliary complication (odds ratio 7.8, 95% confidence interval 1.63-37.27, P = .01), male sex (odds ratio 2.42, 95% confidence interval 1.2-4.87, P = .01), and index operative duration (odds ratio 1.01, 95% confidence interval 1.00-1.01, P = .03) were associated with 30-day readmission. CONCLUSION: Among patients undergoing cholecystectomy for common bile duct stones, jaundice, worsening leukocytosis, and longer operations are associated with postoperative biliary complications. A prior biliary complication is also predictive of a 30-day readmission. Surgeons should recognize these factors and avoid prematurely discharging at-risk patients given their propensity to develop complications and require readmission.


Subject(s)
Cholecystectomy, Laparoscopic , Gallstones/surgery , Postoperative Complications/epidemiology , Adult , Aged , Female , Humans , Male , Middle Aged , Patient Readmission/statistics & numerical data , Prospective Studies , Risk Factors , United States/epidemiology
6.
Am Surg ; 85(9): 1017-1024, 2019 Sep 01.
Article in English | MEDLINE | ID: mdl-31638517

ABSTRACT

Pancreatic necrosis can be managed conservatively; however, infection of pancreatic necrosis usually dictates more aggressive management. Our study aimed to assess the outcomes of open pancreatic necrosectomy (OPN) and endoscopic pancreatic necrosectomy (EPN) in a single center. Data from patients undergoing pancreatic necrosectomy at the Geisinger Medical Center from January 1, 2007, to April 25, 2016, were collected and retrospectively analyzed. Cohorts were composed of EPN (n = 22) and OPN (n = 34) groups. The prevalence of preoperative respiratory failure, septic shock, and multiorgan dysfunction syndrome was higher in the OPN group. The OPN group presented with a higher Bedside Index Severity in Acute Pancreatitis score. Postoperative abscess, persistent kidney dysfunction, and death were more frequent in the OPN group. The EPN group had a higher readmission rate. The results of the univariate analysis for complication and mortality demonstrated that higher mortality and persistent kidney dysfunction were associated with the procedure type, specifically OPN and with a higher Bedside Index Severity in Acute Pancreatitis score. Patients who presented with higher severity of disease underwent an OPN, whereas EPN often was performed successfully in a more benign clinical setting. However, patients with infected necrosis are served best in a tertiary medical facility where multiple treatment modalities are available.


Subject(s)
Debridement/adverse effects , Debridement/methods , Endoscopy/adverse effects , Pancreatitis, Acute Necrotizing/surgery , Adult , Aged , Female , Humans , Male , Middle Aged , Pancreatitis, Acute Necrotizing/complications , Postoperative Complications , Retrospective Studies , Risk Factors , Severity of Illness Index
7.
Am Surg ; 85(8): 865-870, 2019 Aug 01.
Article in English | MEDLINE | ID: mdl-31560305

ABSTRACT

In recent years, nonoperative management of complicated appendicitis has become more common. Patients managed nonoperatively do well, but there is a paucity of literature on patients who fail nonoperative management. The purpose of this study was to examine the overall failure rate, morbidity associated with failure, and potential predictors of failure in nonop management of appendicitis. This is a descriptive retrospective review of patients from a single hospital system who were diagnosed with advanced appendicitis and underwent nonop management between January 1, 2007, and November of 2017. The data were obtained through review of patient charts from the electronic medical record. Failure was defined as requirement of an operation due to ongoing infection secondary to appendicitis. There were 183 patients initially managed nonoperatively, with 70 patients failing nonoperative management. Patients failing nonoperative management experienced longer hospitalization (6.2 vs 2.9 days, P < 0.0001), and more patients in the failure group required admission to the ICU (10.0% vs 1.8%, P = 0.028). Multivariate analysis revealed that longer duration of symptoms reduced the likelihood of failure (odds ratio: 0.77 [0.64-0.92]). In this retrospective review, 38 per cent of patients failed nonop management of appendicitis. Symptom duration could provide insight for clinicians in assessing the role of nonoperative management because increasing symptom duration reduced the likelihood of failure.


Subject(s)
Appendicitis/therapy , Conservative Treatment , Case-Control Studies , Female , Humans , Intensive Care Units/statistics & numerical data , Length of Stay/statistics & numerical data , Male , Middle Aged , Retrospective Studies , Risk Factors , Treatment Failure
8.
Am J Surg ; 217(3): 485-489, 2019 03.
Article in English | MEDLINE | ID: mdl-30415929

ABSTRACT

BACKGROUND: Current guidelines do not specifically address optimal antibiotic duration following cholecystostomy. This study compares outcomes for short-course (<7 days) and long-course (≥7 days) antibiotics post-cholecystostomy. METHODS: This was a retrospective review of cholecystostomy patients (≥18 years) admitted (1/1/2007-12/31/2017) to one healthcare system. RESULTS: Overall, 214 patients were studied. Demographics were similar, except short-course patients had higher Charlson Comorbidity Index (p < 0.0001). There were no intergroup differences in tachycardia (22.5%[short-course] vs 23.3%[long-course]) or leukocytosis (67.1%[short-course] vs 64.4%[long-course]) at drain placement nor time to normalization for pulse, temperature or leukocytosis. There were no differences regarding Clostridium Difficile infection (5.0%[short-course] vs 1.6%[long-course]) or cholecystitis recurrence (8.8%[short-course] vs 10.9%[long-course]). No differences were observed regarding gallbladder-related unplanned readmissions (30-day:18.8%[short-course] vs 17.2%[long-course]; 90-day: 20.0%[short-course] vs 25.8%[long-course]). There were no 30- or 90-day mortality differences (overall mortality: 18.3%). CONCLUSION: Post-cholecystostomy outcomes were comparable between short-course and long-course antibiotics, consistent with emerging literature supporting short-course antibiotics for intra-abdominal infection with source control.


Subject(s)
Anti-Bacterial Agents/administration & dosage , Cholecystitis/surgery , Cholecystostomy , Postoperative Complications/prevention & control , Adult , Aged , Female , Humans , Male , Retrospective Studies
9.
Am J Surg ; 216(6): 1107-1113, 2018 12.
Article in English | MEDLINE | ID: mdl-30424839

ABSTRACT

BACKGROUND: Emergent laparotomies are associated with higher rates of morbidity and mortality. Recent studies suggest sarcopenia predicts worse outcomes in elective operations. The purpose of this study is to examine outcomes following urgent exploratory laparotomy in sarcopenic patients. METHODS: This was a retrospective review of patients in a rural tertiary care facility between 2010 and 2014. Patients underwent a laparotomy within 72 h of admission and had an abdomen/pelvis CT scan were included. Primary outcomes were predictors of morbidity and mortality. Sarcopenia is the lowest quartile cross sectional area of the psoas muscles. RESULTS: Multivariate analysis of 967 patients found that sarcopenic patients had higher mortality, complication rate, were less likely to be discharged home, were more likely to undergo unplanned re-operation, and had a longer length of stay. Increasing abdominal wall fat has favorable outcomes in mortality, discharge destination, and complications. CONCLUSIONS: Sarcopenia is measured from CT scans, making it an accessible outcome predictor. In urgent laparotomies, sarcopenia was associated with higher morbidity, mortality, length of stay, and worse discharge destination.


Subject(s)
Laparotomy/adverse effects , Postoperative Complications/epidemiology , Sarcopenia/complications , Sarcopenia/mortality , Aged , Aged, 80 and over , Female , Humans , Length of Stay , Male , Middle Aged , Psoas Muscles , Reoperation , Retrospective Studies , Sarcopenia/surgery , Tomography, X-Ray Computed
10.
Am J Surg ; 215(4): 586-592, 2018 Apr.
Article in English | MEDLINE | ID: mdl-29100591

ABSTRACT

BACKGROUND: This study characterized the failure rate of non-operative management (NOM) for complicated appendicitis (CA; perforation, abscess, phlegmon), and compared outcomes among patients undergoing acute appendectomy (AA), elective interval appendectomy (EIA), and unplanned appendectomy after failing to improve with NOM. METHODS: Adults treated at one facility between 2007 and 2014 were retrospectively studied. RESULTS: Ninety-five patients presented with CA. Sixty individuals underwent AA. The remaining 35 patients initially underwent NOM: 14 underwent EIA, nine (25.7%) failed NOM, 12 never underwent surgery. All patients failing NOM had an open operation with most (55.6%) requiring bowel resection. AA and EIA were comparable in surgical approach, bowel resection and post-operative readmission. However, AA demonstrated a lower incidence of bowel resection (3.3% vs 17.1%, P = 0.048) when compared to all patients initially undergoing NOM. CONCLUSIONS: Due to the high incidence of failed NOM and the morbidity associated with failure, AA may be appropriate for CA.


Subject(s)
Appendicitis/complications , Appendicitis/therapy , Conservative Treatment/methods , Appendectomy/statistics & numerical data , Appendicitis/surgery , Female , Humans , Male , Middle Aged , Retrospective Studies , Treatment Failure , Treatment Outcome
11.
World J Radiol ; 10(12): 184-189, 2018 Dec 28.
Article in English | MEDLINE | ID: mdl-30631406

ABSTRACT

AIM: To investigate the hemothorax size for which tube thoracostomy is necessary. METHODS: Over a 5-year period, we included all patients who were admitted with blunt chest trauma to our level 1 trauma center. Focus was placed on identifying the hemothorax size requiring tube thoracostomy. RESULTS: A total number of 274 hemothoraces were studied. All patients with hemothoraces measuring above 3 cm received a chest tube. The 50% predicted probability of tube thoracostomy was 2 cm. Pneumothorax was associated with odds of receiving tube thoracostomy for hemothoraces below 2 cm (Odds Ratio: 4.967, 95%CI: 2.225-11.097, P < 0.0001). CONCLUSION: All patients with a hemothorax size greater than 3% underwent tube thoracostomy. Prospective studies are warranted to elucidate the clinical outcome of patients with smaller hemothoraces.

12.
Am Surg ; 83(11): 1203-1208, 2017 Nov 01.
Article in English | MEDLINE | ID: mdl-29183520

ABSTRACT

Elderly patients are at a higher risk of morbidity and mortality after trauma, which is reflected through higher frailty indices. Data collection using existing frailty indices is often not possible because of brain injury, dementia, or inability to communicate with the patient. Sarcopenia is a reliable objective measure for frailty that can be readily assessed in CT imaging. In this study, we aimed to evaluate the effect of sarcopenia on the outcomes of geriatric blunt trauma patients. Left psoas area (LPA) was measured at the level of the third lumbar vertebra on the axial CT images. LPA was normalized for height (LPA mm2/m2) and after stratification by gender, sarcopenia was defined as LPA measurements in the lowest quartile. A total of 1175 patients consisting of 597 males and 578 females were studied. LPAs below 242.6 mm2/m2 in males and below 187.8 mm2/m2 in females were considered to be sarcopenic. We found sarcopenia in 149 males and 145 females. In multivariate analysis, sarcopenia was associated with a higher risk of in-hospital mortality (odds ratio [OR]: 1.61, 95% confidence interval [CI]: 1.01-2.56) and a higher risk of discharge to less favorable destinations (OR: 1.42, 95% CI: 1.05-1.97). Lastly, sarcopenic patients had an increased risk of prolonged hospitalization (hazard ratio: 1.21, 95% CI: 1.04-1.40).


Subject(s)
Sarcopenia/complications , Wounds, Nonpenetrating/complications , Accidental Falls/statistics & numerical data , Aged , Female , Frail Elderly/statistics & numerical data , Hospital Mortality , Humans , Length of Stay/statistics & numerical data , Lumbar Vertebrae/diagnostic imaging , Male , Multivariate Analysis , Prognosis , Psoas Muscles/diagnostic imaging , Risk Factors , Sarcopenia/diagnostic imaging , Sarcopenia/mortality , Tomography, X-Ray Computed , Trauma Severity Indices , Treatment Outcome , United States/epidemiology , Wounds, Nonpenetrating/diagnostic imaging , Wounds, Nonpenetrating/mortality
13.
Mol Plant Microbe Interact ; 30(11): 906-918, 2017 11.
Article in English | MEDLINE | ID: mdl-28795634

ABSTRACT

Plant RBOH (RESPIRATORY BURST OXIDASE HOMOLOGS)-type NADPH oxidases produce superoxide radical anions and have a function in developmental processes and in response to environmental challenges. Barley RBOHF2 has diverse reported functions in interaction with the biotrophic powdery mildew fungus Blumeria graminis f. sp. hordei. Here, we analyzed, in detail, plant leaf level- and age-specific susceptibility of stably RBOHF2-silenced barley plants. This revealed enhanced susceptibility to fungal penetration of young RBOHF2-silenced leaf tissue but strongly reduced susceptibility of older leaves when compared with controls. Loss of susceptibility in old RBOHF2-silenced leaves was associated with spontaneous leaf-tip necrosis and constitutively elevated levels of free and conjugated salicylic acid. Additionally, these leaves more strongly expressed pathogenesis-related genes, both constitutively and during interaction with B. graminis f. sp. hordei. Together, this supports the idea that barley RBOHF2 contributes to basal resistance to powdery mildew infection in young leaf tissue but is required to control leaf cell death, salicylic acid accumulation, and defense gene expression in older leaves, explaining leaf age-specific resistance of RBOHF2-silenced barley plants.


Subject(s)
Ascomycota/physiology , Gene Silencing , Hordeum/microbiology , Plant Diseases/microbiology , Plant Leaves/growth & development , Plant Leaves/metabolism , Plant Proteins/metabolism , Salicylic Acid/metabolism , Cell Death , Gene Expression Regulation, Plant , Genes, Plant , Hordeum/genetics , Hordeum/metabolism , Hydrogen Peroxide/metabolism , Plant Leaves/genetics , Plant Proteins/genetics , Plants, Genetically Modified
14.
Am Surg ; 83(7): 722-727, 2017 Jul 01.
Article in English | MEDLINE | ID: mdl-28738942

ABSTRACT

After blunt trauma, certain CT markers, such as free intraperitoneal air, strongly suggest bowel perforation, whereas other markers, including free intraperitoneal fluid without solid organ injury, may be merely suspicious for acute injury. The present study aims to delineate the safety of nonoperative management for markers of blunt bowel or mesenteric injury (BBMI) that are suspicious for significant bowel injury after blunt trauma. This was a retrospective review of adult blunt trauma patients with abdominopelvic CT scans on admission to a Level I trauma center between 2012 and 2014. Patients with CT evidence of acute BBMI without solid organ injury were included. The CT markers for BBMI included free intraperitoneal fluid, bowel hematoma, bowel wall thickening, mesenteric edema, hematoma and stranding. Two thousand blunt trauma cases were reviewed, and 94 patients (4.7%) met inclusion criteria. The average Injury Severity Score was 13.6 ± 10.1 and the median hospital stay was four days. The most common finding was free fluid (74 patients, 78.7%). The majority of patients (92, 97.9%) remained asymptomatic or clinically improved without abdominal surgery. After a change in abdominal examination, two patients (2.1%) underwent laparotomy with bowel perforation found in only one patient. Thus, 93 patients did not have a surgically significant injury, indicating that these markers demonstrate 1.1 per cent positive predictive value for bowel perforation. The presence of these markers after blunt trauma does not mandate laparotomy, though it should prompt thorough and continued vigilance toward the abdomen.


Subject(s)
Intestines/diagnostic imaging , Intestines/injuries , Laparotomy , Mesentery/diagnostic imaging , Mesentery/injuries , Tomography, X-Ray Computed , Wounds, Nonpenetrating/diagnostic imaging , Adult , Female , Humans , Male , Retrospective Studies , Wounds, Nonpenetrating/therapy
15.
Anesth Analg ; 124(6): 1906-1911, 2017 06.
Article in English | MEDLINE | ID: mdl-28525509

ABSTRACT

BACKGROUND: Rib fractures are commonly encountered in the setting of trauma. The aim of this study was to assess the association between the clinical outcome of rib fracture and epidural analgesia (EA) versus paravertebral block (PVB) using the National Trauma Data Bank (NTDB). METHODS: Using the 2011 and 2012 versions of the NTDB, we retrieved completed records for all patients above 18 years of age who were admitted with rib fractures. Primary outcome was in-hospital mortality. Secondary outcomes were length of stay (LOS), intensive care unit (ICU) admission, ICU LOS, mechanical ventilation, duration of mechanical ventilation, development of pneumonia, and development of any other complication. Clinical outcomes were first compared between propensity score-matched EA and PVB patients. Then, EA and PVB patients were combined into the procedure group and the outcomes were compared with propensity score-matched patients that received neither intervention (no-procedure group). RESULTS: A total of 194,766 patients were included in the study with 1073 patients having EA, 1110 patients having PVB, and 192,583 patients having neither procedure. After propensity score matching, comparison of primary and secondary outcomes between EA and PVB patients showed no difference. Comparison of propensity score-matched procedure and no-procedure patients showed prolonged LOS and more frequent ICU admissions in patients receiving a procedure (both P < .0001), yet having no procedure was associated with a significantly increased odds of mortality (odds ratio: 2.25; 95% confidence interval, 1.14-3.84; P = .002). CONCLUSIONS: Using the NTDB, EA and PVB were not found to be significantly different in management of rib fractures. There was an association between use of a block and improved outcome, but this could be explained by selection of healthier patients to receive a block. Prospective study of this association is recommended.


Subject(s)
Analgesia, Epidural , Fracture Healing , Nerve Block/methods , Pain/prevention & control , Rib Fractures/therapy , Adult , Aged , Analgesia, Epidural/adverse effects , Analgesia, Epidural/mortality , Chi-Square Distribution , Databases, Factual , Female , Hospital Mortality , Humans , Intensive Care Units , Length of Stay , Logistic Models , Male , Middle Aged , Multivariate Analysis , Nerve Block/adverse effects , Nerve Block/mortality , Odds Ratio , Pain/diagnosis , Pain/etiology , Pain/mortality , Pain Measurement , Pneumonia, Ventilator-Associated/etiology , Propensity Score , Respiration, Artificial/adverse effects , Rib Fractures/complications , Rib Fractures/diagnosis , Rib Fractures/mortality , Risk Factors , Time Factors , Treatment Outcome , United States
16.
Am Surg ; 83(1): 39-44, 2017 Jan 01.
Article in English | MEDLINE | ID: mdl-28234124

ABSTRACT

Urban areas house the majority of the population in the United States but trauma deaths occur more commonly in rural areas. In this study, we aimed to investigate if direct patient admission to a Level I trauma center improves outcomes in rural trauma. We retrospectively reviewed data in our trauma database from January 2008 to the end of December 2012 to compare the overall outcomes between direct admissions (DAs) and interhospital transfers (IHTs). Of the 6118 patients who met the inclusion criteria, 59.5 per cent were in the DA group and 40.5 per cent in the IHT group. Injury severity score was similar between the two groups but severe traumatic brain injury was more common (P = 0.001) in the DA group. Hospital length of stay, complication rate, and in-hospital mortality were not different between the two groups (all P> 0.2). In multivariate analysis, there was no difference in survival between the two modes of admission (odds ratio, 95% confidence interval: 0.91, 0.69-1.20, P = 0.51). We concluded that rural trauma IHTs had no detrimental impact on the outcome. Prospective studies would better elucidate factors associated with patient outcomes in rural trauma.


Subject(s)
Outcome Assessment, Health Care , Patient Admission/statistics & numerical data , Patient Transfer/statistics & numerical data , Rural Health Services/statistics & numerical data , Trauma Centers/statistics & numerical data , Wounds and Injuries/mortality , Adult , Aged , Brain Injuries, Traumatic/epidemiology , Brain Injuries, Traumatic/mortality , Female , Hospital Mortality , Humans , Injury Severity Score , Length of Stay/statistics & numerical data , Male , Middle Aged , Multivariate Analysis , Pennsylvania/epidemiology , Retrospective Studies , Survival Analysis , Treatment Outcome , Wounds and Injuries/epidemiology
17.
Am Surg ; 83(12): 1413-1417, 2017 Dec 01.
Article in English | MEDLINE | ID: mdl-29336764

ABSTRACT

Helicopter Emergency Medical Services (HEMS) is presumably an effective way of patient transport in rural trauma, yet the literature addressing its effectiveness is scarce. In this study, we compared the clinical outcome of rural trauma patients between Ground Emergency Medical Services (GEMS) and HEMS transportation from the beginning of 2006 to the end of 2012. Focus was placed on identifying factors associated with survival to discharge in these patients. Over the seven-year study period, 4492 patients met the inclusion criteria with 2414 patients (54%) being transferred by GEMS and 2078 patients (46%) being transferred by HEMS. In comparison with GEMS, patients transferred by HEMS were younger men who were admitted with a higher mean Injury Severity Score and a lower mean Glasgow Coma Score (all Ps < 0.0001). HEMS patients were more frequently intubated before arrival at the trauma center (32% vs 9%, P < 0.0001) and were more frequently transferred to the operating room from the emergency department (11% vs 5%, P < 0.0001). In multivariate analysis, transfer by HEMS was associated with a significant increase in survival to discharge (odds ratio: 1.57, 95% confidence interval: 1.03-2.40, P = 0.036). Blunt injury, no intubation, and Glasgow Coma Score >8 were also associated with significantly improved odds of survival to discharge (all P < 0.0001). These findings show that although patients transferred by HEMS arrived in less favorable clinical conditions, HEMS transfer was associated with significantly higher odds of survival in rural trauma.


Subject(s)
Air Ambulances/statistics & numerical data , Ambulances/statistics & numerical data , Emergency Medical Services/methods , Transportation of Patients/methods , Wounds and Injuries/therapy , Adult , Female , Glasgow Coma Scale , Humans , Injury Severity Score , Male , Middle Aged , Pennsylvania , Retrospective Studies , Rural Population , Survival Rate , Time-to-Treatment
18.
Am J Surg ; 213(2): 399-404, 2017 Feb.
Article in English | MEDLINE | ID: mdl-27575601

ABSTRACT

BACKGROUND: The majority of the US population live in urban areas, yet more than half of all trauma deaths occur in rural areas. The Rural Trauma Team Development Course (RTTDC) is developed to improve the outcomes of rural trauma and we aimed to study its effect on patient transfer. METHODS: Trauma referrals 2 years before the RTTDC training were compared with referrals 2 years after the course. RESULTS: Of the 276 studied patients, 97 were referred before the RTTDC training and 179 patients were referred after the course. Transfer acceptance time was significantly shorter after the RTTDC training (139.2 ± 87.1 vs 110 ± 66.3 min, P = .003). The overall transfer time was also significantly reduced following the RTTDC training (257.4 ± 110.8 vs 219.2 ± 86.5 min, P = .002). Patients receiving pretransfer imaging had a significantly higher transfer time both before and after RTTDC training (all Ps < .01). Mortality was nearly halved (6.2% vs 3.4%) after the RTTDC training. CONCLUSION: The RTTDC training was associated with reduced transfer acceptance time and reduced transfer time.


Subject(s)
Emergency Medical Services/statistics & numerical data , Patient Transfer/statistics & numerical data , Rural Health Services/organization & administration , Traumatology/education , Wounds and Injuries/epidemiology , Adult , Aged , Cohort Studies , Diagnostic Imaging/statistics & numerical data , Female , Humans , Male , Middle Aged , Patient Care Team/organization & administration , Pennsylvania/epidemiology , Referral and Consultation/statistics & numerical data , Retrospective Studies , Rural Population , Time Factors , Trauma Centers , Wounds and Injuries/diagnostic imaging , Young Adult
19.
J Craniofac Surg ; 27(7): 1677-1680, 2016 Oct.
Article in English | MEDLINE | ID: mdl-27391655

ABSTRACT

Facial fractures are commonly managed nonoperatively. Patients with facial fractures involving sinus cavities commonly receive 7 to 10 days of prophylactic antibiotics, yet no literature exists to support or refute this practice. The aim of this study was to compare the administration and duration of antibiotic prophylaxis on the incidence of soft tissue infection in nonoperative facial fractures. A total number of 289 patients who were admitted to our level I trauma center with nonoperative facial fractures from the beginning of 2012 to the end of 2014 were studied. Patients were categorized into 3 groups: no antibiotic prophylaxis, short-term antibiotic prophylaxis (1-5 days), and long-term antibiotic prophylaxis (>5 days). The primary outcome was the incidence of facial soft tissue infection and Clostridium difficile colitis. Fifty patients received no antibiotic prophylaxis. Sixty-three patients completed a short course of antibiotic prophylaxis and 176 patients received long-term antibiotics. Ampicillin/sulbactam, amoxicillin/clavulanic acid, or a combination of both were used in 216 patients. Twenty-three patients received clindamycin due to penicillin allergy. Short and long courses of antibiotic prophylaxis were administered more commonly in patients with concomitant maxillary and orbital fractures (P <0.0001). No mortality was found in any group. Soft tissue infection was not identified in any patient. C. difficile colitis was identified in 1 patient who had received a long course of antibiotic prophylaxis (P = 0.7246). There was no difference in the outcome of patients receiving short-term, long-term, and no antibiotic prophylaxis. Prospective randomized studies are needed to provide further clinical recommendations.


Subject(s)
Anti-Bacterial Agents/therapeutic use , Antibiotic Prophylaxis/statistics & numerical data , Facial Injuries/complications , Skull Fractures/complications , Soft Tissue Infections/prevention & control , Female , Humans , Male , Middle Aged , Prospective Studies , Soft Tissue Infections/etiology
20.
Injury ; 46(11): 2185-9, 2015 Nov.
Article in English | MEDLINE | ID: mdl-26296456

ABSTRACT

OBJECTIVE: To define the role of head computed tomography (CT) scans in the geriatric population with isolated low-energy femur fractures and describe the pertinent clinical variables which are associated with positive CT findings with the objective to decrease the number of unnecessary CT scans performed. DESIGN: Retrospective review. SETTING: Level I trauma centre. PATIENTS: Eleven hundred ninety-two (1192) patients sustaining a femur fracture following a low-energy fall. MAIN OUTCOME MEASUREMENT: Pertinent clinical variables that were associated with CTs that yielded positive findings. RESULTS: Two hundred fifty patients (21%) underwent a head CT scan as part of their evaluation. Of these patients, 83% suffered proximal femur fractures, 11% shaft fractures and 6% distal fractures. The majority of the patients were evaluated by the emergency department (ED) with only 18% (44/250) being evaluated by the trauma team. Average patient age was 83 years (range 65-99 years). One hundred seventy-three patients (69%) were on some form of antiplatelet medication or anticoagulation. Of the 250 patients who underwent head CT scan, 16 (6%) patients had acute findings (haemorrhage - 15, infarct - 1), and none of the patients required neurosurgical intervention. CONCLUSION: None of the patients with a traumatic injury required a neurosurgical invention after sustaining a low energy fall (0/1192). Head CT scans should have a limited role in the work-up of this patient population and should be reserved for patients with a history and physical findings that support head trauma. LEVEL OF EVIDENCE: Prognostic level III. See instructions for authors for a complete description of levels of evidence.


Subject(s)
Geriatric Assessment/methods , Head Injuries, Closed/diagnostic imaging , Hip Fractures/diagnostic imaging , Neurologic Examination , Tomography, X-Ray Computed , Trauma Centers , Unnecessary Procedures , Aged , Aged, 80 and over , Female , Humans , Male , Patient Selection , Retrospective Studies , Tomography, X-Ray Computed/methods
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